Small intestinal bacterial overgrowth in variant transthyretin amyloidosis (A-ATTRv)

Variant transthyretin amyloidosis (A-ATTRv) can lead to sensory, motor, and autonomic neuropathy, as well as a variety of gastrointestinal (GI) disorders. While previous studies have explored gastrointestinal symptoms in A-ATTRv, no studies have definitively examined the role of bacterial overgrowth...

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Autores: Moreno García, Ana, Grimalt Oliver, Mireia, González-Moreno, Juan, Ribot-Sansó, Maria Antonia, Cisneros-Barroso, Eugenia, Losada López, Inés, Losada-López, Inés
Tipo de recurso: artículo
Fecha de publicación:2025
País:España
Institución:Conselleria de Salut i Consum del Govern de les Illes Balears
Repositorio:Docusalut
Idioma:inglés
OAI Identifier:oai:docusalut.com:20.500.13003/24911
Acceso en línea:https://hdl.handle.net/20.500.13003/24911
Access Level:acceso abierto
Palabra clave:ATTR
Breath test
Digestive symptoms
Small intestine bacterial overgrowth
Transthyretin amyloidosis
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spelling Small intestinal bacterial overgrowth in variant transthyretin amyloidosis (A-ATTRv)Moreno García, AnaGrimalt Oliver, MireiaGonzález-Moreno, JuanRibot-Sansó, Maria AntoniaCisneros-Barroso, EugeniaLosada López, InésLosada-López, InésATTRBreath testDigestive symptomsSmall intestine bacterial overgrowthTransthyretin amyloidosisVariant transthyretin amyloidosis (A-ATTRv) can lead to sensory, motor, and autonomic neuropathy, as well as a variety of gastrointestinal (GI) disorders. While previous studies have explored gastrointestinal symptoms in A-ATTRv, no studies have definitively examined the role of bacterial overgrowth, such as SIBO, in exacerbating these symptoms. Identifying the presence of SIBO in A-ATTRv patients could lead to better-targeted treatments for gastrointestinal complications. We conducted a cross-sectional, unicentric observational pilot study, analysing the presence of SIBO using a lactitol breath test in 39 individuals carrying the V30M mutation: 21 asymptomatic carriers and 18 patients with A-ATTRv. We did not find a higher prevalence of SIBO, among patients with A-ATTRv compared to asymptomatic carriers. Though no significant relationship between SIBO and A-ATTRv was found, notable differences in gastrointestinal symptoms suggest these may be independent of SIBO. Furthermore, no relationship was found between the presence of SIBO and gender. Given the limitations of this pilot study, we did not find a relationship between A-ATTRv and intestinal microbiota disorders. Future research with larger sample sizes and more sensitive diagnostic tools is required to further explore this potential link.BMC (Part of Springer Nature)20252025-05-0220252025-05-02research articlehttp://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.13003/24911reponame:Docusalutinstname:Conselleria de Salut i Consum del Govern de les Illes BalearsInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:docusalut.com:20.500.13003/249112026-06-22T12:44:07Z
dc.title.none.fl_str_mv Small intestinal bacterial overgrowth in variant transthyretin amyloidosis (A-ATTRv)
title Small intestinal bacterial overgrowth in variant transthyretin amyloidosis (A-ATTRv)
spellingShingle Small intestinal bacterial overgrowth in variant transthyretin amyloidosis (A-ATTRv)
Moreno García, Ana
ATTR
Breath test
Digestive symptoms
Small intestine bacterial overgrowth
Transthyretin amyloidosis
title_short Small intestinal bacterial overgrowth in variant transthyretin amyloidosis (A-ATTRv)
title_full Small intestinal bacterial overgrowth in variant transthyretin amyloidosis (A-ATTRv)
title_fullStr Small intestinal bacterial overgrowth in variant transthyretin amyloidosis (A-ATTRv)
title_full_unstemmed Small intestinal bacterial overgrowth in variant transthyretin amyloidosis (A-ATTRv)
title_sort Small intestinal bacterial overgrowth in variant transthyretin amyloidosis (A-ATTRv)
dc.creator.none.fl_str_mv Moreno García, Ana
Grimalt Oliver, Mireia
González-Moreno, Juan
Ribot-Sansó, Maria Antonia
Cisneros-Barroso, Eugenia
Losada López, Inés
Losada-López, Inés
author Moreno García, Ana
author_facet Moreno García, Ana
Grimalt Oliver, Mireia
González-Moreno, Juan
Ribot-Sansó, Maria Antonia
Cisneros-Barroso, Eugenia
Losada López, Inés
Losada-López, Inés
author_role author
author2 Grimalt Oliver, Mireia
González-Moreno, Juan
Ribot-Sansó, Maria Antonia
Cisneros-Barroso, Eugenia
Losada López, Inés
Losada-López, Inés
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv ATTR
Breath test
Digestive symptoms
Small intestine bacterial overgrowth
Transthyretin amyloidosis
topic ATTR
Breath test
Digestive symptoms
Small intestine bacterial overgrowth
Transthyretin amyloidosis
description Variant transthyretin amyloidosis (A-ATTRv) can lead to sensory, motor, and autonomic neuropathy, as well as a variety of gastrointestinal (GI) disorders. While previous studies have explored gastrointestinal symptoms in A-ATTRv, no studies have definitively examined the role of bacterial overgrowth, such as SIBO, in exacerbating these symptoms. Identifying the presence of SIBO in A-ATTRv patients could lead to better-targeted treatments for gastrointestinal complications. We conducted a cross-sectional, unicentric observational pilot study, analysing the presence of SIBO using a lactitol breath test in 39 individuals carrying the V30M mutation: 21 asymptomatic carriers and 18 patients with A-ATTRv. We did not find a higher prevalence of SIBO, among patients with A-ATTRv compared to asymptomatic carriers. Though no significant relationship between SIBO and A-ATTRv was found, notable differences in gastrointestinal symptoms suggest these may be independent of SIBO. Furthermore, no relationship was found between the presence of SIBO and gender. Given the limitations of this pilot study, we did not find a relationship between A-ATTRv and intestinal microbiota disorders. Future research with larger sample sizes and more sensitive diagnostic tools is required to further explore this potential link.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025-05-02
2025
2025-05-02
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.13003/24911
url https://hdl.handle.net/20.500.13003/24911
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BMC (Part of Springer Nature)
publisher.none.fl_str_mv BMC (Part of Springer Nature)
dc.source.none.fl_str_mv reponame:Docusalut
instname:Conselleria de Salut i Consum del Govern de les Illes Balears
instname_str Conselleria de Salut i Consum del Govern de les Illes Balears
reponame_str Docusalut
collection Docusalut
repository.name.fl_str_mv
repository.mail.fl_str_mv
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