Diagnosis and Management of Paget's Disease of Bone in Adults: A Clinical Guideline

Producción Científica

Detalles Bibliográficos
Autores: Ralston, Stuart H, Corral Gudino, Luis, Cooper, Cyrus, Francis, Roger M, Fraser, William D, Gennari, Luigi, Guañabens, Núria, Javaid, M Kassim, Layfield, Robert, O'Neill, Terence W, Russell, R Graham G, Stone, Michael D, Simpson, Keith, Wilkinson, Diana, Wills, Ruth, Zillikens, M Carola, Tuck, Stephen P
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Universidad de Valladolid
Repositorio:UVaDOC. Repositorio Documental de la Universidad de Valladolid
OAI Identifier:oai:uvadoc.uva.es:10324/65048
Acceso en línea:https://doi.org/10.1002/jbmr.3657
https://uvadoc.uva.es/handle/10324/65048
Access Level:acceso abierto
Palabra clave:ALP
ANTIRESORPTIVES
BISPHOSPHONATES
PAGET'S DISEASE OF BONE
RADIONUCLIDE BONE SCANS.
3205 Medicina Interna
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spelling Diagnosis and Management of Paget's Disease of Bone in Adults: A Clinical GuidelineRalston, Stuart HCorral Gudino, LuisCooper, CyrusFrancis, Roger MFraser, William DGennari, LuigiGuañabens, NúriaJavaid, M KassimLayfield, RobertO'Neill, Terence WRussell, R Graham GStone, Michael DSimpson, KeithWilkinson, DianaWills, RuthZillikens, M CarolaTuck, Stephen PALPANTIRESORPTIVESBISPHOSPHONATESPAGET'S DISEASE OF BONERADIONUCLIDE BONE SCANS.3205 Medicina InternaProducción CientíficaAn evidence-based clinical guideline for the diagnosis and management of Paget's disease of bone (PDB) was developed using GRADE methodology, by a Guideline Development Group (GDG) led by the Paget's Association (UK). A systematic review of diagnostic tests and pharmacological and nonpharmacological treatment options was conducted that sought to address several key questions of clinical relevance. Twelve recommendations and five conditional recommendations were made, but there was insufficient evidence to address eight of the questions posed. The following recommendations were identified as the most important: 1) Radionuclide bone scans, in addition to targeted radiographs, are recommended as a means of fully and accurately defining the extent of metabolically active disease in patients with PDB. 2) Serum total alkaline phosphatase (ALP) is recommended as a first-line biochemical screening test in combination with liver function tests in screening for the presence of metabolically active PDB. 3) Bisphosphonates are recommended for the treatment of bone pain associated with PDB. Zoledronic acid is recommended as the bisphosphonate most likely to give a favorable pain response. 4) Treatment aimed at improving symptoms is recommended over a treat-to-target strategy aimed at normalizing total ALP in PDB. 5) Total hip or knee replacements are recommended for patients with PDB who develop osteoarthritis in whom medical treatment is inadequate. There is insufficient information to recommend one type of surgical approach over another. The guideline was endorsed by the European Calcified Tissues Society, the International Osteoporosis Foundation, the American Society of Bone and Mineral Research, the Bone Research Society (UK), and the British Geriatric Society. The GDG noted that there had been a lack of research on patient-focused clinical outcomes in PDB and identified several areas where further research was needed.Este trabajo fue financiado por la Paget's Association en Reino Unido y respaldada por las siguientes sociedades European Calcified Tissues Society, la International Osteoporosis Foundation, la American Society of Bone and Mineral Research y la Bone Research Society (UK), y la British Geriatric Society.Wiley2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://doi.org/10.1002/jbmr.3657https://uvadoc.uva.es/handle/10324/65048reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolidinstname:Universidad de ValladolidIngléshttps://asbmr.onlinelibrary.wiley.com/doi/full/10.1002/jbmr.3657info:eu-repo/semantics/openAccessoai:uvadoc.uva.es:10324/650482026-06-13T12:44:47Z
dc.title.none.fl_str_mv Diagnosis and Management of Paget's Disease of Bone in Adults: A Clinical Guideline
title Diagnosis and Management of Paget's Disease of Bone in Adults: A Clinical Guideline
spellingShingle Diagnosis and Management of Paget's Disease of Bone in Adults: A Clinical Guideline
Ralston, Stuart H
ALP
ANTIRESORPTIVES
BISPHOSPHONATES
PAGET'S DISEASE OF BONE
RADIONUCLIDE BONE SCANS.
3205 Medicina Interna
title_short Diagnosis and Management of Paget's Disease of Bone in Adults: A Clinical Guideline
title_full Diagnosis and Management of Paget's Disease of Bone in Adults: A Clinical Guideline
title_fullStr Diagnosis and Management of Paget's Disease of Bone in Adults: A Clinical Guideline
title_full_unstemmed Diagnosis and Management of Paget's Disease of Bone in Adults: A Clinical Guideline
title_sort Diagnosis and Management of Paget's Disease of Bone in Adults: A Clinical Guideline
dc.creator.none.fl_str_mv Ralston, Stuart H
Corral Gudino, Luis
Cooper, Cyrus
Francis, Roger M
Fraser, William D
Gennari, Luigi
Guañabens, Núria
Javaid, M Kassim
Layfield, Robert
O'Neill, Terence W
Russell, R Graham G
Stone, Michael D
Simpson, Keith
Wilkinson, Diana
Wills, Ruth
Zillikens, M Carola
Tuck, Stephen P
author Ralston, Stuart H
author_facet Ralston, Stuart H
Corral Gudino, Luis
Cooper, Cyrus
Francis, Roger M
Fraser, William D
Gennari, Luigi
Guañabens, Núria
Javaid, M Kassim
Layfield, Robert
O'Neill, Terence W
Russell, R Graham G
Stone, Michael D
Simpson, Keith
Wilkinson, Diana
Wills, Ruth
Zillikens, M Carola
Tuck, Stephen P
author_role author
author2 Corral Gudino, Luis
Cooper, Cyrus
Francis, Roger M
Fraser, William D
Gennari, Luigi
Guañabens, Núria
Javaid, M Kassim
Layfield, Robert
O'Neill, Terence W
Russell, R Graham G
Stone, Michael D
Simpson, Keith
Wilkinson, Diana
Wills, Ruth
Zillikens, M Carola
Tuck, Stephen P
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ALP
ANTIRESORPTIVES
BISPHOSPHONATES
PAGET'S DISEASE OF BONE
RADIONUCLIDE BONE SCANS.
3205 Medicina Interna
topic ALP
ANTIRESORPTIVES
BISPHOSPHONATES
PAGET'S DISEASE OF BONE
RADIONUCLIDE BONE SCANS.
3205 Medicina Interna
description Producción Científica
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.1002/jbmr.3657
https://uvadoc.uva.es/handle/10324/65048
url https://doi.org/10.1002/jbmr.3657
https://uvadoc.uva.es/handle/10324/65048
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://asbmr.onlinelibrary.wiley.com/doi/full/10.1002/jbmr.3657
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolid
instname:Universidad de Valladolid
instname_str Universidad de Valladolid
reponame_str UVaDOC. Repositorio Documental de la Universidad de Valladolid
collection UVaDOC. Repositorio Documental de la Universidad de Valladolid
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,198674

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