Intra-aneurysmal pressure and flow changes induced by flow diverters: relation to aneurysm size and shape
Background and purpose: Effects of blood flow modification by flow diverters are observed to lead often to aneurysm thrombosis and reverse remodeling. For this process, to further understand the potential roles of intra-aneurysmal blood pressure changes and aneurysm morphologies, 23 patients were st...
| Autores: | , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2013 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:10230/59145 |
| Acceso en línea: | http://hdl.handle.net/10230/59145 http://dx.doi.org/10.3174/ajnr.A3288 |
| Access Level: | acceso abierto |
| Palabra clave: | Aneurismes cerebrals Imatgeria tridimensional en medicina Hemodinàmica |
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Intra-aneurysmal pressure and flow changes induced by flow diverters: relation to aneurysm size and shapeLarrabide, Ignacio, 1978-Aguilar, María LauraMorales, Hernán G.Geers, Adrianus JohannesKulcsár, ZsoltRüfenacht, DanielFrangi Caregnato, AlejandroAneurismes cerebralsImatgeria tridimensional en medicinaHemodinàmicaBackground and purpose: Effects of blood flow modification by flow diverters are observed to lead often to aneurysm thrombosis and reverse remodeling. For this process, to further understand the potential roles of intra-aneurysmal blood pressure changes and aneurysm morphologies, 23 patients were studied by numeric simulation. Materials and methods: 3D imaging of aneurysms of different sizes and shapes, all located at the supraclinoid segment of the ICA (n = 23), was prepared for CFD simulations. Hemodynamic variables were calculated for conditions before and after virtual FD implantation, reconstituting a vessel wall scaffold across the aneurysm neck. WSS, velocity, residence time, turnover time, and intra-aneurysmal pressure were assessed statistically. Results: After placement of FDs, significant reductions inside the aneurysm were observed for most hemodynamic variables (P < .01) except mean intra-aneurysmal pressures. For minimum/maximum intra-aneurysmal pressure values, small but significant changes were found; however, they were considered too small to be of relevance. Conclusions: Calculations in 23 cases did not reveal significant intra-aneurysmal mean or peak pressure changes, indicating a minor role of pressure changes in the rare event of secondary ruptures after FD use. Other hemodynamic variables (WSS and velocity) exhibited more significant changes, indicating their role in intra-aneurysmal thrombus formation. Size-dependent, significantly higher reduction in WSS (P = .069) and velocity (P = .013) was observed in small aneurysms compared with larger ones. When it came to shape, there were significantly higher reductions in WSS (P = .055) and velocity (P = .065) and a significantly higher increase in turnover time in fusiform aneurysms compared with saccular aneurysms.This research has been partially funded by the Industrial and Technological Development Center (CDTI) under the CENIT-CDTEAM and CENIT-cvREMOD programs, the European Commission project @neurIST (IST-2005-027703), and Philips Healthcare.American Society of Neuroradiology202420242013info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/59145http://dx.doi.org/10.3174/ajnr.A3288reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésAmerican Journal of Neuroradiology. 2013 Apr 1;34(4):816-22info:eu-repo/grantAgreement/EC/FP6/027703© 2013 by American Journal of Neuroradiology. Indicates open access to non-subscribers at www.ajnr.org.info:eu-repo/semantics/openAccessoai:recercat.cat:10230/591452026-05-29T05:05:01Z |
| dc.title.none.fl_str_mv |
Intra-aneurysmal pressure and flow changes induced by flow diverters: relation to aneurysm size and shape |
| title |
Intra-aneurysmal pressure and flow changes induced by flow diverters: relation to aneurysm size and shape |
| spellingShingle |
Intra-aneurysmal pressure and flow changes induced by flow diverters: relation to aneurysm size and shape Larrabide, Ignacio, 1978- Aneurismes cerebrals Imatgeria tridimensional en medicina Hemodinàmica |
| title_short |
Intra-aneurysmal pressure and flow changes induced by flow diverters: relation to aneurysm size and shape |
| title_full |
Intra-aneurysmal pressure and flow changes induced by flow diverters: relation to aneurysm size and shape |
| title_fullStr |
Intra-aneurysmal pressure and flow changes induced by flow diverters: relation to aneurysm size and shape |
| title_full_unstemmed |
Intra-aneurysmal pressure and flow changes induced by flow diverters: relation to aneurysm size and shape |
| title_sort |
Intra-aneurysmal pressure and flow changes induced by flow diverters: relation to aneurysm size and shape |
| dc.creator.none.fl_str_mv |
Larrabide, Ignacio, 1978- Aguilar, María Laura Morales, Hernán G. Geers, Adrianus Johannes Kulcsár, Zsolt Rüfenacht, Daniel Frangi Caregnato, Alejandro |
| author |
Larrabide, Ignacio, 1978- |
| author_facet |
Larrabide, Ignacio, 1978- Aguilar, María Laura Morales, Hernán G. Geers, Adrianus Johannes Kulcsár, Zsolt Rüfenacht, Daniel Frangi Caregnato, Alejandro |
| author_role |
author |
| author2 |
Aguilar, María Laura Morales, Hernán G. Geers, Adrianus Johannes Kulcsár, Zsolt Rüfenacht, Daniel Frangi Caregnato, Alejandro |
| author2_role |
author author author author author author |
| dc.subject.none.fl_str_mv |
Aneurismes cerebrals Imatgeria tridimensional en medicina Hemodinàmica |
| topic |
Aneurismes cerebrals Imatgeria tridimensional en medicina Hemodinàmica |
| description |
Background and purpose: Effects of blood flow modification by flow diverters are observed to lead often to aneurysm thrombosis and reverse remodeling. For this process, to further understand the potential roles of intra-aneurysmal blood pressure changes and aneurysm morphologies, 23 patients were studied by numeric simulation. Materials and methods: 3D imaging of aneurysms of different sizes and shapes, all located at the supraclinoid segment of the ICA (n = 23), was prepared for CFD simulations. Hemodynamic variables were calculated for conditions before and after virtual FD implantation, reconstituting a vessel wall scaffold across the aneurysm neck. WSS, velocity, residence time, turnover time, and intra-aneurysmal pressure were assessed statistically. Results: After placement of FDs, significant reductions inside the aneurysm were observed for most hemodynamic variables (P < .01) except mean intra-aneurysmal pressures. For minimum/maximum intra-aneurysmal pressure values, small but significant changes were found; however, they were considered too small to be of relevance. Conclusions: Calculations in 23 cases did not reveal significant intra-aneurysmal mean or peak pressure changes, indicating a minor role of pressure changes in the rare event of secondary ruptures after FD use. Other hemodynamic variables (WSS and velocity) exhibited more significant changes, indicating their role in intra-aneurysmal thrombus formation. Size-dependent, significantly higher reduction in WSS (P = .069) and velocity (P = .013) was observed in small aneurysms compared with larger ones. When it came to shape, there were significantly higher reductions in WSS (P = .055) and velocity (P = .065) and a significantly higher increase in turnover time in fusiform aneurysms compared with saccular aneurysms. |
| publishDate |
2013 |
| dc.date.none.fl_str_mv |
2013 2024 2024 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10230/59145 http://dx.doi.org/10.3174/ajnr.A3288 |
| url |
http://hdl.handle.net/10230/59145 http://dx.doi.org/10.3174/ajnr.A3288 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
American Journal of Neuroradiology. 2013 Apr 1;34(4):816-22 info:eu-repo/grantAgreement/EC/FP6/027703 |
| dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
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application/pdf application/pdf |
| dc.publisher.none.fl_str_mv |
American Society of Neuroradiology |
| publisher.none.fl_str_mv |
American Society of Neuroradiology |
| dc.source.none.fl_str_mv |
reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| instname_str |
Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Recercat. Dipósit de la Recerca de Catalunya |
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Recercat. Dipósit de la Recerca de Catalunya |
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15,812429 |