Cryoballoon Ablation for Persistent and Paroxysmal Atrial Fibrillation

Vallès, Ermengol|||0000-0001-5474-8274; Jiménez, Jesús; Martí-Almor, Julio|||0000-0001-9927-1190; Toquero, Jorge; Ormaetxe, José Miguel; Barrera, Alberto; García-Alberola, Arcadio|||0000-0003-1928-865X; Rubio, José Manuel; Moriña, Pablo; Grande, Carlos; Fé Arcocha, Maria|||0000-0002-3494-8276; Peinado, Rafael; Cózar, Rocío|||0000-0002-5184-4014; Hernández, Julio; Pérez-Alvarez, Luisa; Gaztañaga, Larraitz; Ferrero De Loma Osorio, Ángel; Ruiz-Granell, Ricardo; Villuendas-Sabaté, Roger|||0000-0001-9110-905X; Martínez-Alday, Jesús Daniel

Cryoballoon Ablation for Persistent and Paroxysmal Atrial Fibrillation

Introduction: Cryoballoon ablation (CBA) has become a standard treatment for paroxysmal atrial fibrillation (PaAF) but limited data is available for outcomes in patients with persistent atrial fibrillation (PeAF). Methods: We analyzed the first 944 patients included in the Spanish Prospective Multi-...

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Autores:	Vallès, Ermengol\|\|\|0000-0001-5474-8274, Jiménez, Jesús, Martí-Almor, Julio\|\|\|0000-0001-9927-1190, Toquero, Jorge, Ormaetxe, José Miguel, Barrera, Alberto, García-Alberola, Arcadio\|\|\|0000-0003-1928-865X, Rubio, José Manuel, Moriña, Pablo, Grande, Carlos, Fé Arcocha, Maria\|\|\|0000-0002-3494-8276, Peinado, Rafael, Cózar, Rocío\|\|\|0000-0002-5184-4014, Hernández, Julio, Pérez-Alvarez, Luisa, Gaztañaga, Larraitz, Ferrero De Loma Osorio, Ángel, Ruiz-Granell, Ricardo, Villuendas-Sabaté, Roger\|\|\|0000-0001-9110-905X, Martínez-Alday, Jesús Daniel
Tipo de recurso:	artículo
Fecha de publicación:	2022
País:	España
Institución:	Universitat Autònoma de Barcelona
Repositorio:	Dipòsit Digital de Documents de la UAB
Idioma:	inglés
OAI Identifier:	oai:ddd.uab.cat:258939
Acceso en línea:	https://ddd.uab.cat/record/258939 https://dx.doi.org/urn:doi:10.3390/jcm11051166
Access Level:	acceso abierto
Palabra clave:	Persistent atrial fibrillation Cryoballoon procedure Registry

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spelling	Cryoballoon Ablation for Persistent and Paroxysmal Atrial FibrillationProcedural Differences and Results from the Spanish Registry (RECABA)Vallès, Ermengol\|\|\|0000-0001-5474-8274Jiménez, JesúsMartí-Almor, Julio\|\|\|0000-0001-9927-1190Toquero, JorgeOrmaetxe, José MiguelBarrera, AlbertoGarcía-Alberola, Arcadio\|\|\|0000-0003-1928-865XRubio, José ManuelMoriña, PabloGrande, CarlosFé Arcocha, Maria\|\|\|0000-0002-3494-8276Peinado, RafaelCózar, Rocío\|\|\|0000-0002-5184-4014Hernández, JulioPérez-Alvarez, LuisaGaztañaga, LarraitzFerrero De Loma Osorio, ÁngelRuiz-Granell, RicardoVilluendas-Sabaté, Roger\|\|\|0000-0001-9110-905XMartínez-Alday, Jesús DanielPersistent atrial fibrillationCryoballoon procedureRegistryIntroduction: Cryoballoon ablation (CBA) has become a standard treatment for paroxysmal atrial fibrillation (PaAF) but limited data is available for outcomes in patients with persistent atrial fibrillation (PeAF). Methods: We analyzed the first 944 patients included in the Spanish Prospective Multi-center Observation Post-market Registry to compare characteristics and outcomes of patients undergoing CBA for PeAF versus PaAF. Results: A total of 944 patients (57.8 ± 10.4 years; 70.1% male) with AF (27.9% persistent) were prospectively included from 25 centers. PeAF patients were more likely to have structural heart disease (67.7 vs. 11.4%; p < 0.001) and left atrium dilation (72.6 vs. 43.3%; p < 0.001). CBA of PeAF was less likely to be performed under general anesthesia (10.7 vs. 22.2%; p < 0.001), with an arterial line (32.2 vs. 44.6%; p < 0.001) and assisted transeptal puncture (11.9 vs. 17.9%; p = 0.025). During an application, PeAF patients had a longer time to -30 °C (35.91 ± 14.20 vs. 34.93 ± 12.87 s; p = 0.021) and a colder balloon nadir temperature during vein isolation (-35.04 ± 9.58 vs. -33.61 ± 10.32 °C; p = 0.004), but received fewer bonus freeze applications (30.7 vs. 41.1%; p < 0.001). There were no differences in acute pulmonary vein isolation and procedure-related complications. Overall, 76.7% of patients were free from AF recurrences at 15-month follow-up (78.9% in PaAF vs. 70.9% in PeAF; p = 0.09). Conclusions: Patients with PeAF have a more diseased substrate, and CBA procedures performed in such patients were more simplified, although longer/colder freeze applications were often applied. The acute efficacy/safety profile of CBA was similar between PaAF and PeAF patients, but long-term results were better in PaAF patients.Universitat Autònoma de Barcelona 22022-01-0120222022-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/258939https://dx.doi.org/urn:doi:10.3390/jcm11051166reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2589392026-06-06T12:50:31Z
dc.title.none.fl_str_mv	Cryoballoon Ablation for Persistent and Paroxysmal Atrial Fibrillation Procedural Differences and Results from the Spanish Registry (RECABA)
title	Cryoballoon Ablation for Persistent and Paroxysmal Atrial Fibrillation
spellingShingle	Cryoballoon Ablation for Persistent and Paroxysmal Atrial Fibrillation Vallès, Ermengol\|\|\|0000-0001-5474-8274 Persistent atrial fibrillation Cryoballoon procedure Registry
title_short	Cryoballoon Ablation for Persistent and Paroxysmal Atrial Fibrillation
title_full	Cryoballoon Ablation for Persistent and Paroxysmal Atrial Fibrillation
title_fullStr	Cryoballoon Ablation for Persistent and Paroxysmal Atrial Fibrillation
title_full_unstemmed	Cryoballoon Ablation for Persistent and Paroxysmal Atrial Fibrillation
title_sort	Cryoballoon Ablation for Persistent and Paroxysmal Atrial Fibrillation
dc.creator.none.fl_str_mv	Vallès, Ermengol\|\|\|0000-0001-5474-8274 Jiménez, Jesús Martí-Almor, Julio\|\|\|0000-0001-9927-1190 Toquero, Jorge Ormaetxe, José Miguel Barrera, Alberto García-Alberola, Arcadio\|\|\|0000-0003-1928-865X Rubio, José Manuel Moriña, Pablo Grande, Carlos Fé Arcocha, Maria\|\|\|0000-0002-3494-8276 Peinado, Rafael Cózar, Rocío\|\|\|0000-0002-5184-4014 Hernández, Julio Pérez-Alvarez, Luisa Gaztañaga, Larraitz Ferrero De Loma Osorio, Ángel Ruiz-Granell, Ricardo Villuendas-Sabaté, Roger\|\|\|0000-0001-9110-905X Martínez-Alday, Jesús Daniel
author	Vallès, Ermengol\|\|\|0000-0001-5474-8274
author_facet	Vallès, Ermengol\|\|\|0000-0001-5474-8274 Jiménez, Jesús Martí-Almor, Julio\|\|\|0000-0001-9927-1190 Toquero, Jorge Ormaetxe, José Miguel Barrera, Alberto García-Alberola, Arcadio\|\|\|0000-0003-1928-865X Rubio, José Manuel Moriña, Pablo Grande, Carlos Fé Arcocha, Maria\|\|\|0000-0002-3494-8276 Peinado, Rafael Cózar, Rocío\|\|\|0000-0002-5184-4014 Hernández, Julio Pérez-Alvarez, Luisa Gaztañaga, Larraitz Ferrero De Loma Osorio, Ángel Ruiz-Granell, Ricardo Villuendas-Sabaté, Roger\|\|\|0000-0001-9110-905X Martínez-Alday, Jesús Daniel
author_role	author
author2	Jiménez, Jesús Martí-Almor, Julio\|\|\|0000-0001-9927-1190 Toquero, Jorge Ormaetxe, José Miguel Barrera, Alberto García-Alberola, Arcadio\|\|\|0000-0003-1928-865X Rubio, José Manuel Moriña, Pablo Grande, Carlos Fé Arcocha, Maria\|\|\|0000-0002-3494-8276 Peinado, Rafael Cózar, Rocío\|\|\|0000-0002-5184-4014 Hernández, Julio Pérez-Alvarez, Luisa Gaztañaga, Larraitz Ferrero De Loma Osorio, Ángel Ruiz-Granell, Ricardo Villuendas-Sabaté, Roger\|\|\|0000-0001-9110-905X Martínez-Alday, Jesús Daniel
author2_role	author author author author author author author author author author author author author author author author author author author
dc.contributor.none.fl_str_mv	Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv	Persistent atrial fibrillation Cryoballoon procedure Registry
topic	Persistent atrial fibrillation Cryoballoon procedure Registry
description	Introduction: Cryoballoon ablation (CBA) has become a standard treatment for paroxysmal atrial fibrillation (PaAF) but limited data is available for outcomes in patients with persistent atrial fibrillation (PeAF). Methods: We analyzed the first 944 patients included in the Spanish Prospective Multi-center Observation Post-market Registry to compare characteristics and outcomes of patients undergoing CBA for PeAF versus PaAF. Results: A total of 944 patients (57.8 ± 10.4 years; 70.1% male) with AF (27.9% persistent) were prospectively included from 25 centers. PeAF patients were more likely to have structural heart disease (67.7 vs. 11.4%; p < 0.001) and left atrium dilation (72.6 vs. 43.3%; p < 0.001). CBA of PeAF was less likely to be performed under general anesthesia (10.7 vs. 22.2%; p < 0.001), with an arterial line (32.2 vs. 44.6%; p < 0.001) and assisted transeptal puncture (11.9 vs. 17.9%; p = 0.025). During an application, PeAF patients had a longer time to -30 °C (35.91 ± 14.20 vs. 34.93 ± 12.87 s; p = 0.021) and a colder balloon nadir temperature during vein isolation (-35.04 ± 9.58 vs. -33.61 ± 10.32 °C; p = 0.004), but received fewer bonus freeze applications (30.7 vs. 41.1%; p < 0.001). There were no differences in acute pulmonary vein isolation and procedure-related complications. Overall, 76.7% of patients were free from AF recurrences at 15-month follow-up (78.9% in PaAF vs. 70.9% in PeAF; p = 0.09). Conclusions: Patients with PeAF have a more diseased substrate, and CBA procedures performed in such patients were more simplified, although longer/colder freeze applications were often applied. The acute efficacy/safety profile of CBA was similar between PaAF and PeAF patients, but long-term results were better in PaAF patients.
publishDate	2022
dc.date.none.fl_str_mv	2 2022-01-01 2022 2022-01-01
dc.type.none.fl_str_mv	Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://ddd.uab.cat/record/258939 https://dx.doi.org/urn:doi:10.3390/jcm11051166
url	https://ddd.uab.cat/record/258939 https://dx.doi.org/urn:doi:10.3390/jcm11051166
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv	openAccess
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dc.source.none.fl_str_mv	reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona
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Cryoballoon Ablation for Persistent and Paroxysmal Atrial Fibrillation

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