New insights into the toxicological effects of dietary biogenic amines

Biogenic amines (BA) are molecules with biological functions, which can accumulate at toxic concentrations in foods. Several microorganisms have been identified as responsible for their accumulation at elevated concentrations. Histamine, tyramine and putrescine are the BA most commonly found at high...

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Detalles Bibliográficos
Autores: Río Lagar, Beatriz del, Fernández García, María, Redruello, Begoña, Ladero Losada, Víctor Manuel, Álvarez González, Miguel Ángel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/368259
Acceso en línea:http://hdl.handle.net/10261/368259
https://api.elsevier.com/content/abstract/scopus_id/85172865673
Access Level:acceso abierto
Palabra clave:Biogenic amines
Food intoxication
Food safety
Histamine
Toxicology
Tyramine
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spelling New insights into the toxicological effects of dietary biogenic aminesRío Lagar, Beatriz delFernández García, MaríaRedruello, BegoñaLadero Losada, Víctor ManuelÁlvarez González, Miguel ÁngelBiogenic aminesFood intoxicationFood safetyHistamineToxicologyTyramineBiogenic amines (BA) are molecules with biological functions, which can accumulate at toxic concentrations in foods. Several microorganisms have been identified as responsible for their accumulation at elevated concentrations. Histamine, tyramine and putrescine are the BA most commonly found at highest concentrations. The ingestion of food containing high BA concentrations leads to intoxication with symptoms depending on the BA and the amount consumed. Moreover, there is evidence of synergy between different BA, something of toxicological importance given that some foods accumulate different BA. This work reviews the BA toxic effects and examines recent discoveries regarding their synergy, cytotoxicity and genotoxicity. These advances in the toxicological consequences of ingesting BA contaminated foods support the need to regulate their presence in foods to preserve the consumer's health. However, more research efforts -focused on the establishment of risk assessments- are needed to reach a consensus in their limits in different food matrices.This work was funded by the Plan for Science, Technology and Innovation of the Principality of Asturias 2018– 2022, co-financed by FEDER (Grant AYUD/2021/50916) and by MCIN/AEI/10.13039/501100011033 (Grant PID2020‐112629RB‐I00). The authors acknowledge support received by the Unit of Information Resources for Research (URICI-CSIC) through its CSIC Open Access Publication Support Initiative. The authors also thank Adrian Burton for language and editing assistance.Peer reviewedElsevierPrincipado de AsturiasEuropean CommissionAgencia Estatal de Investigación (España)Ministerio de Ciencia, Innovación y Universidades (España)CSIC - Unidad de Recursos de Información Científica para la Investigación (URICI)Redruello, Begoña [0000-0003-1787-5594]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202420242024info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/368259https://api.elsevier.com/content/abstract/scopus_id/85172865673reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-112629RB-I00https://doi.org/10.1016/j.foodchem.2023.137558Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3682592026-05-22T06:33:51Z
dc.title.none.fl_str_mv New insights into the toxicological effects of dietary biogenic amines
title New insights into the toxicological effects of dietary biogenic amines
spellingShingle New insights into the toxicological effects of dietary biogenic amines
Río Lagar, Beatriz del
Biogenic amines
Food intoxication
Food safety
Histamine
Toxicology
Tyramine
title_short New insights into the toxicological effects of dietary biogenic amines
title_full New insights into the toxicological effects of dietary biogenic amines
title_fullStr New insights into the toxicological effects of dietary biogenic amines
title_full_unstemmed New insights into the toxicological effects of dietary biogenic amines
title_sort New insights into the toxicological effects of dietary biogenic amines
dc.creator.none.fl_str_mv Río Lagar, Beatriz del
Fernández García, María
Redruello, Begoña
Ladero Losada, Víctor Manuel
Álvarez González, Miguel Ángel
author Río Lagar, Beatriz del
author_facet Río Lagar, Beatriz del
Fernández García, María
Redruello, Begoña
Ladero Losada, Víctor Manuel
Álvarez González, Miguel Ángel
author_role author
author2 Fernández García, María
Redruello, Begoña
Ladero Losada, Víctor Manuel
Álvarez González, Miguel Ángel
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Principado de Asturias
European Commission
Agencia Estatal de Investigación (España)
Ministerio de Ciencia, Innovación y Universidades (España)
CSIC - Unidad de Recursos de Información Científica para la Investigación (URICI)
Redruello, Begoña [0000-0003-1787-5594]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Biogenic amines
Food intoxication
Food safety
Histamine
Toxicology
Tyramine
topic Biogenic amines
Food intoxication
Food safety
Histamine
Toxicology
Tyramine
description Biogenic amines (BA) are molecules with biological functions, which can accumulate at toxic concentrations in foods. Several microorganisms have been identified as responsible for their accumulation at elevated concentrations. Histamine, tyramine and putrescine are the BA most commonly found at highest concentrations. The ingestion of food containing high BA concentrations leads to intoxication with symptoms depending on the BA and the amount consumed. Moreover, there is evidence of synergy between different BA, something of toxicological importance given that some foods accumulate different BA. This work reviews the BA toxic effects and examines recent discoveries regarding their synergy, cytotoxicity and genotoxicity. These advances in the toxicological consequences of ingesting BA contaminated foods support the need to regulate their presence in foods to preserve the consumer's health. However, more research efforts -focused on the establishment of risk assessments- are needed to reach a consensus in their limits in different food matrices.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/368259
https://api.elsevier.com/content/abstract/scopus_id/85172865673
url http://hdl.handle.net/10261/368259
https://api.elsevier.com/content/abstract/scopus_id/85172865673
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-112629RB-I00
https://doi.org/10.1016/j.foodchem.2023.137558
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
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dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
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