Obstructive Sleep Apnoea Syndrome, Endothelial Function and Markers of Endothelialization. Changes after CPAP

Study objectives This study tries to assess the endothelial function in vivo using flow-mediated dilatation (FMD) and several biomarkers of endothelium formation/restoration and damage in patients with obstructive sleep apnoea (OSA) syndrome at baseline and after three months with CPAP therapy. Desi...

Descripción completa

Detalles Bibliográficos
Autores: Muñoz Hernández, Rocio, Vallejo Vaz, Antonio J., Sánchez Armengol, Angeles, Moreno Luna, Rafael, Caballero Eraso, Candelaria, Macher, Hada C., Villar, Jose, Merino, Ana, Castell, Javier, Capote, Francisco, Stiefel, Pablo
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/126146
Acceso en línea:https://hdl.handle.net/2445/126146
Access Level:acceso abierto
Palabra clave:Pressió sanguínia
Endoteli
Blood pressure
Endothelium
id ES_daa36fcda37489f33632096c8a697903
oai_identifier_str oai:diposit.ub.edu:2445/126146
network_acronym_str ES
network_name_str España
repository_id_str
spelling Obstructive Sleep Apnoea Syndrome, Endothelial Function and Markers of Endothelialization. Changes after CPAPMuñoz Hernández, RocioVallejo Vaz, Antonio J.Sánchez Armengol, AngelesMoreno Luna, RafaelCaballero Eraso, CandelariaMacher, Hada C.Villar, JoseMerino, AnaCastell, JavierCapote, FranciscoStiefel, PabloPressió sanguíniaEndoteliBlood pressureEndotheliumStudy objectives This study tries to assess the endothelial function in vivo using flow-mediated dilatation (FMD) and several biomarkers of endothelium formation/restoration and damage in patients with obstructive sleep apnoea (OSA) syndrome at baseline and after three months with CPAP therapy. Design Observational study, before and after CPAP therapy. Setting and Patients We studied 30 patients with apnoea/hypopnoea index (AHI) > 15/h that were compared with themselves after three months of CPAP therapy. FMD was assessed non-invasively in vivo using the Laser-Doppler flowmetry. Circulating cell-free DNA (cf-DNA) and microparticles (MPs) were measured as markers of endothelial damage and the vascular endothelial growth factor (VEGF) was determined as a marker of endothelial restoration process. Measurements and results After three month with CPAP, FMD significantly increased (1072.26 +/- 483.21 vs. 1604.38 +/- 915.69 PU, p<0.005) cf-DNA and MPs significantly decreased (187.93 +/- 115.81 vs. 121.28 +/- 78.98 pg/ml, p<0.01, and 69.60 +/- 62.60 vs. 39.82 +/- 22.14 U/mu L, p<0.05, respectively) and VEGF levels increased (585.02 +/- 246.06 vs. 641.11 +/- 212.69 pg/ml, p<0.05). These changes were higher in patients with more severe disease. There was a relationship between markers of damage (r = -0.53, p< 0.005) but not between markers of damage and restoration, thus suggesting that both types of markers should be measured together. Conclusions CPAP therapy improves FMD. This improvement may be related to an increase of endothelial restoration process and a decrease of endothelial damage.Public Library of Science (PLoS)2015info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/126146Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1371/journal.pone.0122091PLoS One, 2015, vol. 10, num. 3, p. e0122091https://doi.org/10.1371/journal.pone.0122091cc by (c) Muñoz Hernández et al., 2015http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1261462026-05-27T06:46:51Z
dc.title.none.fl_str_mv Obstructive Sleep Apnoea Syndrome, Endothelial Function and Markers of Endothelialization. Changes after CPAP
title Obstructive Sleep Apnoea Syndrome, Endothelial Function and Markers of Endothelialization. Changes after CPAP
spellingShingle Obstructive Sleep Apnoea Syndrome, Endothelial Function and Markers of Endothelialization. Changes after CPAP
Muñoz Hernández, Rocio
Pressió sanguínia
Endoteli
Blood pressure
Endothelium
title_short Obstructive Sleep Apnoea Syndrome, Endothelial Function and Markers of Endothelialization. Changes after CPAP
title_full Obstructive Sleep Apnoea Syndrome, Endothelial Function and Markers of Endothelialization. Changes after CPAP
title_fullStr Obstructive Sleep Apnoea Syndrome, Endothelial Function and Markers of Endothelialization. Changes after CPAP
title_full_unstemmed Obstructive Sleep Apnoea Syndrome, Endothelial Function and Markers of Endothelialization. Changes after CPAP
title_sort Obstructive Sleep Apnoea Syndrome, Endothelial Function and Markers of Endothelialization. Changes after CPAP
dc.creator.none.fl_str_mv Muñoz Hernández, Rocio
Vallejo Vaz, Antonio J.
Sánchez Armengol, Angeles
Moreno Luna, Rafael
Caballero Eraso, Candelaria
Macher, Hada C.
Villar, Jose
Merino, Ana
Castell, Javier
Capote, Francisco
Stiefel, Pablo
author Muñoz Hernández, Rocio
author_facet Muñoz Hernández, Rocio
Vallejo Vaz, Antonio J.
Sánchez Armengol, Angeles
Moreno Luna, Rafael
Caballero Eraso, Candelaria
Macher, Hada C.
Villar, Jose
Merino, Ana
Castell, Javier
Capote, Francisco
Stiefel, Pablo
author_role author
author2 Vallejo Vaz, Antonio J.
Sánchez Armengol, Angeles
Moreno Luna, Rafael
Caballero Eraso, Candelaria
Macher, Hada C.
Villar, Jose
Merino, Ana
Castell, Javier
Capote, Francisco
Stiefel, Pablo
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Pressió sanguínia
Endoteli
Blood pressure
Endothelium
topic Pressió sanguínia
Endoteli
Blood pressure
Endothelium
description Study objectives This study tries to assess the endothelial function in vivo using flow-mediated dilatation (FMD) and several biomarkers of endothelium formation/restoration and damage in patients with obstructive sleep apnoea (OSA) syndrome at baseline and after three months with CPAP therapy. Design Observational study, before and after CPAP therapy. Setting and Patients We studied 30 patients with apnoea/hypopnoea index (AHI) > 15/h that were compared with themselves after three months of CPAP therapy. FMD was assessed non-invasively in vivo using the Laser-Doppler flowmetry. Circulating cell-free DNA (cf-DNA) and microparticles (MPs) were measured as markers of endothelial damage and the vascular endothelial growth factor (VEGF) was determined as a marker of endothelial restoration process. Measurements and results After three month with CPAP, FMD significantly increased (1072.26 +/- 483.21 vs. 1604.38 +/- 915.69 PU, p<0.005) cf-DNA and MPs significantly decreased (187.93 +/- 115.81 vs. 121.28 +/- 78.98 pg/ml, p<0.01, and 69.60 +/- 62.60 vs. 39.82 +/- 22.14 U/mu L, p<0.05, respectively) and VEGF levels increased (585.02 +/- 246.06 vs. 641.11 +/- 212.69 pg/ml, p<0.05). These changes were higher in patients with more severe disease. There was a relationship between markers of damage (r = -0.53, p< 0.005) but not between markers of damage and restoration, thus suggesting that both types of markers should be measured together. Conclusions CPAP therapy improves FMD. This improvement may be related to an increase of endothelial restoration process and a decrease of endothelial damage.
publishDate 2015
dc.date.none.fl_str_mv 2015
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/126146
url https://hdl.handle.net/2445/126146
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0122091
PLoS One, 2015, vol. 10, num. 3, p. e0122091
https://doi.org/10.1371/journal.pone.0122091
dc.rights.none.fl_str_mv cc by (c) Muñoz Hernández et al., 2015
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Muñoz Hernández et al., 2015
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Public Library of Science (PLoS)
publisher.none.fl_str_mv Public Library of Science (PLoS)
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869421597899620352
score 15,300719

Similares en LA Referencia