Systematic review and meta-analysis: analysis of variables influencing the interpretation of clinical trial results in NAFLD

[Background] NAFLD clinical trials have shown suboptimal results, particularly for liver fibrosis, despite the robust preclinical drug development. We aimed to assess the histological response after the experimental treatment versus placebo by carrying out a meta-analysis of NAFLD clinical trials.

Detalles Bibliográficos
Autores: Ampuero, Javier, Gallego-Durán, Rocío, Maya-Miles, Douglas, Montero, Rocío, Gato, Sheila, Rojas, Ángela, Gil, Antonio, Muñoz, Rocío, Romero-Gómez, Manuel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/307260
Acceso en línea:http://hdl.handle.net/10261/307260
https://api.elsevier.com/content/abstract/scopus_id/85127116365
Access Level:acceso abierto
Palabra clave:Placebo
Drug
Fibrosis
NAFLD
NASH
Descripción
Sumario:[Background] NAFLD clinical trials have shown suboptimal results, particularly for liver fibrosis, despite the robust preclinical drug development. We aimed to assess the histological response after the experimental treatment versus placebo by carrying out a meta-analysis of NAFLD clinical trials.

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