Low-cost impedance measurements for lab-on-a-chip architectures: Towards potentiostat miniaturization

The development of miniaturized potentiostats capable of measuring in a wide range of conditions and with full characteristics (e.g., wide bandwidth and capacitive/inductive contribution to sensor's impedance) is still an unresolved challenge in bioelectronics. We present a simple analogue desi...

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Detalles Bibliográficos
Autores: Pruna Morales, Raquel, Palacio Bonet, Francisco, Baraket, Abdoullatif, Bausells, Joan, Errachid, Abdelhamid, López de Miguel, Manuel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/152689
Acceso en línea:https://hdl.handle.net/2445/152689
Access Level:acceso abierto
Palabra clave:Espectroscòpia d'impedància
Insuficiència cardíaca
Bioelectrònica
Amplificadors (Electrònica)
Impedance spectroscopy
Heart failure
Bioelectronics
Amplifiers (Electronics)
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repository_id_str
spelling Low-cost impedance measurements for lab-on-a-chip architectures: Towards potentiostat miniaturizationPruna Morales, RaquelPalacio Bonet, FranciscoBaraket, AbdoullatifBausells, JoanErrachid, AbdelhamidLópez de Miguel, ManuelEspectroscòpia d'impedànciaInsuficiència cardíacaBioelectrònicaAmplificadors (Electrònica)Impedance spectroscopyHeart failureBioelectronicsAmplifiers (Electronics)The development of miniaturized potentiostats capable of measuring in a wide range of conditions and with full characteristics (e.g., wide bandwidth and capacitive/inductive contribution to sensor's impedance) is still an unresolved challenge in bioelectronics. We present a simple analogue design coupled to a digital filter based on a lock-in amplifier as an alternative to complex architectures reported hitherto. A low-cost, miniaturized and fully integrated acquisition electronic system was developed, tested for a fully integrated three-lead electrochemical biosensor and benchmarked against a commercial potentiostat. The portable potentiostat was coupled to an array of miniaturized gold working electrodes to perform complex impedance analyses for tumor necrosis factor α (TNF-α) cytokine detection. This wearable potentiostat is very promising for the development of low-cost point-of-care (POC) with low power consumption.MDPI2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/152689Articles publicats en revistes (Enginyeria Electrònica i Biomèdica)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3390/proceedings1040604MDPI Proceedings, 2017, vol. 1, num. 4, p. 604https://doi.org/10.3390/proceedings1040604info:eu-repo/grantAgreement/EC/FP7/614168info:eu-repo/grantAgreement/EC/H2020/643694cc-by (c) Pruna Morales, Raquel et al., 2017http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1526892026-05-27T06:46:51Z
dc.title.none.fl_str_mv Low-cost impedance measurements for lab-on-a-chip architectures: Towards potentiostat miniaturization
title Low-cost impedance measurements for lab-on-a-chip architectures: Towards potentiostat miniaturization
spellingShingle Low-cost impedance measurements for lab-on-a-chip architectures: Towards potentiostat miniaturization
Pruna Morales, Raquel
Espectroscòpia d'impedància
Insuficiència cardíaca
Bioelectrònica
Amplificadors (Electrònica)
Impedance spectroscopy
Heart failure
Bioelectronics
Amplifiers (Electronics)
title_short Low-cost impedance measurements for lab-on-a-chip architectures: Towards potentiostat miniaturization
title_full Low-cost impedance measurements for lab-on-a-chip architectures: Towards potentiostat miniaturization
title_fullStr Low-cost impedance measurements for lab-on-a-chip architectures: Towards potentiostat miniaturization
title_full_unstemmed Low-cost impedance measurements for lab-on-a-chip architectures: Towards potentiostat miniaturization
title_sort Low-cost impedance measurements for lab-on-a-chip architectures: Towards potentiostat miniaturization
dc.creator.none.fl_str_mv Pruna Morales, Raquel
Palacio Bonet, Francisco
Baraket, Abdoullatif
Bausells, Joan
Errachid, Abdelhamid
López de Miguel, Manuel
author Pruna Morales, Raquel
author_facet Pruna Morales, Raquel
Palacio Bonet, Francisco
Baraket, Abdoullatif
Bausells, Joan
Errachid, Abdelhamid
López de Miguel, Manuel
author_role author
author2 Palacio Bonet, Francisco
Baraket, Abdoullatif
Bausells, Joan
Errachid, Abdelhamid
López de Miguel, Manuel
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Espectroscòpia d'impedància
Insuficiència cardíaca
Bioelectrònica
Amplificadors (Electrònica)
Impedance spectroscopy
Heart failure
Bioelectronics
Amplifiers (Electronics)
topic Espectroscòpia d'impedància
Insuficiència cardíaca
Bioelectrònica
Amplificadors (Electrònica)
Impedance spectroscopy
Heart failure
Bioelectronics
Amplifiers (Electronics)
description The development of miniaturized potentiostats capable of measuring in a wide range of conditions and with full characteristics (e.g., wide bandwidth and capacitive/inductive contribution to sensor's impedance) is still an unresolved challenge in bioelectronics. We present a simple analogue design coupled to a digital filter based on a lock-in amplifier as an alternative to complex architectures reported hitherto. A low-cost, miniaturized and fully integrated acquisition electronic system was developed, tested for a fully integrated three-lead electrochemical biosensor and benchmarked against a commercial potentiostat. The portable potentiostat was coupled to an array of miniaturized gold working electrodes to perform complex impedance analyses for tumor necrosis factor α (TNF-α) cytokine detection. This wearable potentiostat is very promising for the development of low-cost point-of-care (POC) with low power consumption.
publishDate 2017
dc.date.none.fl_str_mv 2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/152689
url https://hdl.handle.net/2445/152689
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/proceedings1040604
MDPI Proceedings, 2017, vol. 1, num. 4, p. 604
https://doi.org/10.3390/proceedings1040604
info:eu-repo/grantAgreement/EC/FP7/614168
info:eu-repo/grantAgreement/EC/H2020/643694
dc.rights.none.fl_str_mv cc-by (c) Pruna Morales, Raquel et al., 2017
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Pruna Morales, Raquel et al., 2017
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Enginyeria Electrònica i Biomèdica)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301629

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