Modulation of the Endocannabinoids N-Arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) on Executive Functions in Human

Animal studies point to an implication of the endocannabinoid system on executive functions. In humans, several studies have suggested an association between acute or chronic use of exogenous cannabinoids (Δ9-tetrahydrocannabinol) and executive impairments. However, to date, no published reports est...

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Autores: Fagundo, Ana B., Torre, Rafael de la, Jiménez-Murcia, Susana, Agüera, Zaida, Pastor, Antoni, Casanueva, Felipe F., Granero, Roser, Baños, Rosa M., Botella, Cristina, Pino Gutiérrez, Amparo del, Fernández-Real Lemos, José Manuel, Fernández García, Jose C., Frühbeck, Gema, Gómez Ambrosi, Javier, Menchón Magriñá, José Manuel, Moragrega Vergara, Inés, Rodríguez, Roser, Tárrega, Salomé, Tinahones, Francisco J., Fernández Aranda, Fernando
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2013
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10256/25050
Acceso en línea:http://hdl.handle.net/10256/25050
Access Level:acceso abierto
Palabra clave:Funcions executives (Neuropsicologia)
Executive functions (Neuropsychology)
Cannabinoides
Cannabinoids
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spelling Modulation of the Endocannabinoids N-Arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) on Executive Functions in HumanFagundo, Ana B.Torre, Rafael de laJiménez-Murcia, SusanaAgüera, ZaidaPastor, AntoniCasanueva, Felipe F.Granero, RoserBaños, Rosa M.Botella, CristinaPino Gutiérrez, Amparo delFernández-Real Lemos, José ManuelFernández García, Jose C.Frühbeck, GemaGómez Ambrosi, JavierMenchón Magriñá, José ManuelMoragrega Vergara, InésRodríguez, RoserTárrega, SaloméTinahones, Francisco J.Fernández Aranda, FernandoFuncions executives (Neuropsicologia)Executive functions (Neuropsychology)CannabinoidesCannabinoidsAnimal studies point to an implication of the endocannabinoid system on executive functions. In humans, several studies have suggested an association between acute or chronic use of exogenous cannabinoids (Δ9-tetrahydrocannabinol) and executive impairments. However, to date, no published reports establish the relationship between endocannabinoids, as biomarkers of the cannabinoid neurotransmission system, and executive functioning in humans. The aim of the present study was to explore the association between circulating levels of plasma endocannabinoids N-arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) and executive functions (decision making, response inhibition and cognitive flexibility) in healthy subjects. One hundred and fifty seven subjects were included and assessed with the Wisconsin Card Sorting Test; Stroop Color and Word Test; and Iowa Gambling Task. All participants were female, aged between 18 and 60 years and spoke Spanish as their first language. Results showed a negative correlation between 2-AG and cognitive flexibility performance (r = −.37; p<.05). A positive correlation was found between AEA concentrations and both cognitive flexibility (r = .59; p<.05) and decision making performance (r = .23; P<.05). There was no significant correlation between either 2-AG (r = −.17) or AEA (r = −.08) concentrations and inhibition response. These results show, in humans, a relevant modulation of the endocannabinoid system on prefrontal-dependent cognitive functioning. The present study might have significant implications for the underlying executive alterations described in some psychiatric disorders currently associated with endocannabinoids deregulation (namely drug abuse/dependence, depression, obesity and eating disorders). Understanding the neurobiology of their dysexecutive profile might certainly contribute to the development of new treatments and pharmacological approachesPublic Library of Science (PLoS)2013info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionpeer-reviewedapplication/pdfhttp://hdl.handle.net/10256/25050http://hdl.handle.net/10256/25050PLoS ONE, 2013, vol. 8, núm. 6, p. e66387Articles publicats (D-CM)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)Inglésinfo:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0066387info:eu-repo/semantics/altIdentifier/eissn/1932-6203Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10256/250502026-05-29T05:05:01Z
dc.title.none.fl_str_mv Modulation of the Endocannabinoids N-Arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) on Executive Functions in Human
title Modulation of the Endocannabinoids N-Arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) on Executive Functions in Human
spellingShingle Modulation of the Endocannabinoids N-Arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) on Executive Functions in Human
Fagundo, Ana B.
Funcions executives (Neuropsicologia)
Executive functions (Neuropsychology)
Cannabinoides
Cannabinoids
title_short Modulation of the Endocannabinoids N-Arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) on Executive Functions in Human
title_full Modulation of the Endocannabinoids N-Arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) on Executive Functions in Human
title_fullStr Modulation of the Endocannabinoids N-Arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) on Executive Functions in Human
title_full_unstemmed Modulation of the Endocannabinoids N-Arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) on Executive Functions in Human
title_sort Modulation of the Endocannabinoids N-Arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) on Executive Functions in Human
dc.creator.none.fl_str_mv Fagundo, Ana B.
Torre, Rafael de la
Jiménez-Murcia, Susana
Agüera, Zaida
Pastor, Antoni
Casanueva, Felipe F.
Granero, Roser
Baños, Rosa M.
Botella, Cristina
Pino Gutiérrez, Amparo del
Fernández-Real Lemos, José Manuel
Fernández García, Jose C.
Frühbeck, Gema
Gómez Ambrosi, Javier
Menchón Magriñá, José Manuel
Moragrega Vergara, Inés
Rodríguez, Roser
Tárrega, Salomé
Tinahones, Francisco J.
Fernández Aranda, Fernando
author Fagundo, Ana B.
author_facet Fagundo, Ana B.
Torre, Rafael de la
Jiménez-Murcia, Susana
Agüera, Zaida
Pastor, Antoni
Casanueva, Felipe F.
Granero, Roser
Baños, Rosa M.
Botella, Cristina
Pino Gutiérrez, Amparo del
Fernández-Real Lemos, José Manuel
Fernández García, Jose C.
Frühbeck, Gema
Gómez Ambrosi, Javier
Menchón Magriñá, José Manuel
Moragrega Vergara, Inés
Rodríguez, Roser
Tárrega, Salomé
Tinahones, Francisco J.
Fernández Aranda, Fernando
author_role author
author2 Torre, Rafael de la
Jiménez-Murcia, Susana
Agüera, Zaida
Pastor, Antoni
Casanueva, Felipe F.
Granero, Roser
Baños, Rosa M.
Botella, Cristina
Pino Gutiérrez, Amparo del
Fernández-Real Lemos, José Manuel
Fernández García, Jose C.
Frühbeck, Gema
Gómez Ambrosi, Javier
Menchón Magriñá, José Manuel
Moragrega Vergara, Inés
Rodríguez, Roser
Tárrega, Salomé
Tinahones, Francisco J.
Fernández Aranda, Fernando
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Funcions executives (Neuropsicologia)
Executive functions (Neuropsychology)
Cannabinoides
Cannabinoids
topic Funcions executives (Neuropsicologia)
Executive functions (Neuropsychology)
Cannabinoides
Cannabinoids
description Animal studies point to an implication of the endocannabinoid system on executive functions. In humans, several studies have suggested an association between acute or chronic use of exogenous cannabinoids (Δ9-tetrahydrocannabinol) and executive impairments. However, to date, no published reports establish the relationship between endocannabinoids, as biomarkers of the cannabinoid neurotransmission system, and executive functioning in humans. The aim of the present study was to explore the association between circulating levels of plasma endocannabinoids N-arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) and executive functions (decision making, response inhibition and cognitive flexibility) in healthy subjects. One hundred and fifty seven subjects were included and assessed with the Wisconsin Card Sorting Test; Stroop Color and Word Test; and Iowa Gambling Task. All participants were female, aged between 18 and 60 years and spoke Spanish as their first language. Results showed a negative correlation between 2-AG and cognitive flexibility performance (r = −.37; p<.05). A positive correlation was found between AEA concentrations and both cognitive flexibility (r = .59; p<.05) and decision making performance (r = .23; P<.05). There was no significant correlation between either 2-AG (r = −.17) or AEA (r = −.08) concentrations and inhibition response. These results show, in humans, a relevant modulation of the endocannabinoid system on prefrontal-dependent cognitive functioning. The present study might have significant implications for the underlying executive alterations described in some psychiatric disorders currently associated with endocannabinoids deregulation (namely drug abuse/dependence, depression, obesity and eating disorders). Understanding the neurobiology of their dysexecutive profile might certainly contribute to the development of new treatments and pharmacological approaches
publishDate 2013
dc.date.none.fl_str_mv 2013
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
peer-reviewed
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10256/25050
http://hdl.handle.net/10256/25050
url http://hdl.handle.net/10256/25050
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0066387
info:eu-repo/semantics/altIdentifier/eissn/1932-6203
dc.rights.none.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Public Library of Science (PLoS)
publisher.none.fl_str_mv Public Library of Science (PLoS)
dc.source.none.fl_str_mv PLoS ONE, 2013, vol. 8, núm. 6, p. e66387
Articles publicats (D-CM)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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