Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits

Vogelezang, Suzanne; Bradfield, Jonathan P; Ahluwalia, Tarunveer S; Curtin, John A; Lakka, Timo A; Grarup, Niels; Scholz, Markus; van der Most, Peter J; Monnereau, Claire; Stergiakouli, Evie; Heiskala, Anni; Horikoshi, Momoko; Fedko, Iryna O; Vilor-Tejedor, Natalia; Cousminer, Diana L; Standl, Marie; Wang, Carol A; Viikari, Jorma; Geller, Frank; iniguez, Carmen; Pitkanen, Niina; Chesi, Alessandra; Bacelis, Jonas; Yengo, Loic; Torrent Quetglas, Maties; Ntalla, Ioanna; Helgeland, Øyvind; Selzam, Saskia; Vonk, Judith M; Zafarmand, Mohammed H; Heude, Barbara; Farooqi, Ismaa Sadaf; Alyass, Akram; Beaumont, Robin N; Have, Christian T; Rzehak, Peter; Bilbao, Jose Ramon; Schnurr, Theresia M; Barroso, Ines; Bonnelykke, Klaus; Beilin, Lawrence J; Carstensen, Lisbeth; Charles, Marie-Aline; Chawes, Bo; Clement, Karine; Closa-Monasterolo, Ricardo; Custovic, Adnan; Eriksson, Johan G; Escribano, Joaquin; Groen-Blokhuis, Maria; Grote, Veit; Gruszfeld, Dariusz; Hakonarson, Hakon; Hansen, Torben; Hattersley, Andrew T; Hollensted, Mette; Hottenga, Jouke-Jan; Hyppönen, Elina; Johansson, Stefan; Joro, Raimo; Kähönen, Mika; Karhunen, Ville; Kiess, Wieland; Knight, Bridget A; Koletzko, Berthold; Küehnapfel, Andreas; Landgraf, Kathrin; Langhendries, Jean-Paul; Lehtimäki, Terho; Leinonen, Jaakko T; Li, Aihuali; Lindi, Virpi; Lowry, Estelle; Bustamante, Mariona; Medina-Gomez, Carolina; Melbye, Mads; Michaelsen, Kim F; Morgen, Camilla S; Mori, Trevor A; Nielsen, Tenna RH; Niinikoski, Harri; Oldehinkel, Albertine J; Pahkala, Katja; Panoutsopoulou, Kalliope; Pedersen, Oluf; Pennell, Craig E; Power, Christine; Reijneveld, Sijmen A; Rivadeneira, Fernando; Simpson, Angela; Sly, Peter D; Stokholm, Jakob; Teo, Kook K; Thiering, Elisabeth; Timpson, Nicholas J; Uitterlinden, Andre G; van Beijsterveldt, Catharina E. M; van Schaik, Barbera D. C; Vaudel, Marc; Verduci, Elvira; Vinding, Rebecca K; Vogel, Mandy; Zeggini, Eleftheria; Sebert, Sylvain; Lind, Mads V; Brown, Christopher D; Santa-Marina, Loreto; Reischl, Eva; Frithioff-Bøjsøe, Christine; Meyre, David; Wheeler, Eleanor; Ong, Ken; Nohr, Ellen A; Vrijkotte, Tanja G. M; Koppelman, Gerard H; Plomin, Robert; Njølstad, Pal R; Dedoussis, George D; Froguel, Philippe; Sorensen, Thorkild I. A; Jacobsson, Bo; Freathy, Rachel M; Zemel, Babette S; Raitakari, Olli; Vrijheid, Martine; Feenstra, Bjarke; Lyytikäinen, Leo-Pekka; Snieder, Harold; Kirsten, Holger; Holt, Patrick G; Heinrich, Joachim; Widen, Elisabeth; Sunyer, Jordi; Boomsma, Dorret I; Järvelin, Marjo-Riitta; Köerner, Antje; Davey Smith, George; Holm, Jens-Christian; Atalay, Mustafa; Murray, Clare; Bisgaard, Hans; McCarthy, Mark I; Early Growth Genetics Consortium; Jaddoe, Vincent WV; Grant, Struan FA; Felix, Janine F

Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits

The genetic background of childhood body mass index (BMI), and the extent to which the well-known associations of childhood BMI with adult diseases are explained by shared genetic factors, are largely unknown. We performed a genome-wide association study meta-analysis of BMI in 61,111 children aged...

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Autores:	Vogelezang, Suzanne, Bradfield, Jonathan P, Ahluwalia, Tarunveer S, Curtin, John A, Lakka, Timo A, Grarup, Niels, Scholz, Markus, van der Most, Peter J, Monnereau, Claire, Stergiakouli, Evie, Heiskala, Anni, Horikoshi, Momoko, Fedko, Iryna O, Vilor-Tejedor, Natalia, Cousminer, Diana L, Standl, Marie, Wang, Carol A, Viikari, Jorma, Geller, Frank, iniguez, Carmen, Pitkanen, Niina, Chesi, Alessandra, Bacelis, Jonas, Yengo, Loic, Torrent Quetglas, Maties, Ntalla, Ioanna, Helgeland, Øyvind, Selzam, Saskia, Vonk, Judith M, Zafarmand, Mohammed H, Heude, Barbara, Farooqi, Ismaa Sadaf, Alyass, Akram, Beaumont, Robin N, Have, Christian T, Rzehak, Peter, Bilbao, Jose Ramon, Schnurr, Theresia M, Barroso, Ines, Bonnelykke, Klaus, Beilin, Lawrence J, Carstensen, Lisbeth, Charles, Marie-Aline, Chawes, Bo, Clement, Karine, Closa-Monasterolo, Ricardo, Custovic, Adnan, Eriksson, Johan G, Escribano, Joaquin, Groen-Blokhuis, Maria, Grote, Veit, Gruszfeld, Dariusz, Hakonarson, Hakon, Hansen, Torben, Hattersley, Andrew T, Hollensted, Mette, Hottenga, Jouke-Jan, Hyppönen, Elina, Johansson, Stefan, Joro, Raimo, Kähönen, Mika, Karhunen, Ville, Kiess, Wieland, Knight, Bridget A, Koletzko, Berthold, Küehnapfel, Andreas, Landgraf, Kathrin, Langhendries, Jean-Paul, Lehtimäki, Terho, Leinonen, Jaakko T, Li, Aihuali, Lindi, Virpi, Lowry, Estelle, Bustamante, Mariona, Medina-Gomez, Carolina, Melbye, Mads, Michaelsen, Kim F, Morgen, Camilla S, Mori, Trevor A, Nielsen, Tenna RH, Niinikoski, Harri, Oldehinkel, Albertine J, Pahkala, Katja, Panoutsopoulou, Kalliope, Pedersen, Oluf, Pennell, Craig E, Power, Christine, Reijneveld, Sijmen A, Rivadeneira, Fernando, Simpson, Angela, Sly, Peter D, Stokholm, Jakob, Teo, Kook K, Thiering, Elisabeth, Timpson, Nicholas J, Uitterlinden, Andre G, van Beijsterveldt, Catharina E. M, van Schaik, Barbera D. C, Vaudel, Marc, Verduci, Elvira, Vinding, Rebecca K, Vogel, Mandy, Zeggini, Eleftheria, Sebert, Sylvain, Lind, Mads V, Brown, Christopher D, Santa-Marina, Loreto, Reischl, Eva, Frithioff-Bøjsøe, Christine, Meyre, David, Wheeler, Eleanor, Ong, Ken, Nohr, Ellen A, Vrijkotte, Tanja G. M, Koppelman, Gerard H, Plomin, Robert, Njølstad, Pal R, Dedoussis, George D, Froguel, Philippe, Sorensen, Thorkild I. A, Jacobsson, Bo, Freathy, Rachel M, Zemel, Babette S, Raitakari, Olli, Vrijheid, Martine, Feenstra, Bjarke, Lyytikäinen, Leo-Pekka, Snieder, Harold, Kirsten, Holger, Holt, Patrick G, Heinrich, Joachim, Widen, Elisabeth, Sunyer, Jordi, Boomsma, Dorret I, Järvelin, Marjo-Riitta, Köerner, Antje, Davey Smith, George, Holm, Jens-Christian, Atalay, Mustafa, Murray, Clare, Bisgaard, Hans, McCarthy, Mark I, Early Growth Genetics Consortium, Jaddoe, Vincent WV, Grant, Struan FA, Felix, Janine F
Formato:	artículo
Fecha de publicación:	2020
País:	España
Recursos:	Instituto de Salud Carlos III (ISCIII)
Repositorio:	Repisalud
Idioma:	inglés
OAI Identifier:	oai:repisalud.isciii.es:20.500.12105/23028
Acesso em linha:	https://hdl.handle.net/20.500.12105/23028
Access Level:	acceso abierto
Palavra-chave:	Índice de Masa Corporal Análisis de la Aleatorización Mendeliana Relación Cintura-Cadera Factores de Riesgo Cardiometabólico Predisposición Genética a la Enfermedad Femenino Ubiquitina-Proteína Ligasas Nedd4 Proteínas de Transporte de Monosacáridos Adolescente Masculino Menarquia Estudio de Asociación del Genoma Completo Preescolar Presión Sanguínea Humanos Diabetes Mellitus Tipo 2 Enfermedades Cardiovasculares Niño Adulto Cardiovascular Diseases Child Diabetes Mellitus, Type 2 Genetic Predisposition to Disease Cardiometabolic Risk Factors Adult Humans Mendelian Randomization Analysis Child, Preschool Adolescent Waist-Hip Ratio Blood Pressure Monosaccharide Transport Proteins Male Menarche Nedd4 Ubiquitin Protein Ligases Female Body Mass Index Genome-Wide Association Study

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oai_identifier_str	oai:repisalud.isciii.es:20.500.12105/23028
network_acronym_str	ES
network_name_str	España
repository_id_str
dc.title.none.fl_str_mv	Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits
title	Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits
spellingShingle	Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits Vogelezang, Suzanne Índice de Masa Corporal Análisis de la Aleatorización Mendeliana Relación Cintura-Cadera Factores de Riesgo Cardiometabólico Predisposición Genética a la Enfermedad Femenino Ubiquitina-Proteína Ligasas Nedd4 Proteínas de Transporte de Monosacáridos Adolescente Masculino Menarquia Estudio de Asociación del Genoma Completo Preescolar Presión Sanguínea Humanos Diabetes Mellitus Tipo 2 Enfermedades Cardiovasculares Niño Adulto Cardiovascular Diseases Child Diabetes Mellitus, Type 2 Genetic Predisposition to Disease Cardiometabolic Risk Factors Adult Humans Mendelian Randomization Analysis Child, Preschool Adolescent Waist-Hip Ratio Blood Pressure Monosaccharide Transport Proteins Male Menarche Nedd4 Ubiquitin Protein Ligases Female Body Mass Index Genome-Wide Association Study
title_short	Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits
title_full	Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits
title_fullStr	Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits
title_full_unstemmed	Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits
title_sort	Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits
dc.creator.none.fl_str_mv	Vogelezang, Suzanne Bradfield, Jonathan P Ahluwalia, Tarunveer S Curtin, John A Lakka, Timo A Grarup, Niels Scholz, Markus van der Most, Peter J Monnereau, Claire Stergiakouli, Evie Heiskala, Anni Horikoshi, Momoko Fedko, Iryna O Vilor-Tejedor, Natalia Cousminer, Diana L Standl, Marie Wang, Carol A Viikari, Jorma Geller, Frank iniguez, Carmen Pitkanen, Niina Chesi, Alessandra Bacelis, Jonas Yengo, Loic Torrent Quetglas, Maties Ntalla, Ioanna Helgeland, Øyvind Selzam, Saskia Vonk, Judith M Zafarmand, Mohammed H Heude, Barbara Farooqi, Ismaa Sadaf Alyass, Akram Beaumont, Robin N Have, Christian T Rzehak, Peter Bilbao, Jose Ramon Schnurr, Theresia M Barroso, Ines Bonnelykke, Klaus Beilin, Lawrence J Carstensen, Lisbeth Charles, Marie-Aline Chawes, Bo Clement, Karine Closa-Monasterolo, Ricardo Custovic, Adnan Eriksson, Johan G Escribano, Joaquin Groen-Blokhuis, Maria Grote, Veit Gruszfeld, Dariusz Hakonarson, Hakon Hansen, Torben Hattersley, Andrew T Hollensted, Mette Hottenga, Jouke-Jan Hyppönen, Elina Johansson, Stefan Joro, Raimo Kähönen, Mika Karhunen, Ville Kiess, Wieland Knight, Bridget A Koletzko, Berthold Küehnapfel, Andreas Landgraf, Kathrin Langhendries, Jean-Paul Lehtimäki, Terho Leinonen, Jaakko T Li, Aihuali Lindi, Virpi Lowry, Estelle Bustamante, Mariona Medina-Gomez, Carolina Melbye, Mads Michaelsen, Kim F Morgen, Camilla S Mori, Trevor A Nielsen, Tenna RH Niinikoski, Harri Oldehinkel, Albertine J Pahkala, Katja Panoutsopoulou, Kalliope Pedersen, Oluf Pennell, Craig E Power, Christine Reijneveld, Sijmen A Rivadeneira, Fernando Simpson, Angela Sly, Peter D Stokholm, Jakob Teo, Kook K Thiering, Elisabeth Timpson, Nicholas J Uitterlinden, Andre G van Beijsterveldt, Catharina E. M van Schaik, Barbera D. C Vaudel, Marc Verduci, Elvira Vinding, Rebecca K Vogel, Mandy Zeggini, Eleftheria Sebert, Sylvain Lind, Mads V Brown, Christopher D Santa-Marina, Loreto Reischl, Eva Frithioff-Bøjsøe, Christine Meyre, David Wheeler, Eleanor Ong, Ken Nohr, Ellen A Vrijkotte, Tanja G. M Koppelman, Gerard H Plomin, Robert Njølstad, Pal R Dedoussis, George D Froguel, Philippe Sorensen, Thorkild I. A Jacobsson, Bo Freathy, Rachel M Zemel, Babette S Raitakari, Olli Vrijheid, Martine Feenstra, Bjarke Lyytikäinen, Leo-Pekka Snieder, Harold Kirsten, Holger Holt, Patrick G Heinrich, Joachim Widen, Elisabeth Sunyer, Jordi Boomsma, Dorret I Järvelin, Marjo-Riitta Köerner, Antje Davey Smith, George Holm, Jens-Christian Atalay, Mustafa Murray, Clare Bisgaard, Hans McCarthy, Mark I Early Growth Genetics Consortium Jaddoe, Vincent WV Grant, Struan FA Felix, Janine F
author	Vogelezang, Suzanne
author_facet	Vogelezang, Suzanne Bradfield, Jonathan P Ahluwalia, Tarunveer S Curtin, John A Lakka, Timo A Grarup, Niels Scholz, Markus van der Most, Peter J Monnereau, Claire Stergiakouli, Evie Heiskala, Anni Horikoshi, Momoko Fedko, Iryna O Vilor-Tejedor, Natalia Cousminer, Diana L Standl, Marie Wang, Carol A Viikari, Jorma Geller, Frank iniguez, Carmen Pitkanen, Niina Chesi, Alessandra Bacelis, Jonas Yengo, Loic Torrent Quetglas, Maties Ntalla, Ioanna Helgeland, Øyvind Selzam, Saskia Vonk, Judith M Zafarmand, Mohammed H Heude, Barbara Farooqi, Ismaa Sadaf Alyass, Akram Beaumont, Robin N Have, Christian T Rzehak, Peter Bilbao, Jose Ramon Schnurr, Theresia M Barroso, Ines Bonnelykke, Klaus Beilin, Lawrence J Carstensen, Lisbeth Charles, Marie-Aline Chawes, Bo Clement, Karine Closa-Monasterolo, Ricardo Custovic, Adnan Eriksson, Johan G Escribano, Joaquin Groen-Blokhuis, Maria Grote, Veit Gruszfeld, Dariusz Hakonarson, Hakon Hansen, Torben Hattersley, Andrew T Hollensted, Mette Hottenga, Jouke-Jan Hyppönen, Elina Johansson, Stefan Joro, Raimo Kähönen, Mika Karhunen, Ville Kiess, Wieland Knight, Bridget A Koletzko, Berthold Küehnapfel, Andreas Landgraf, Kathrin Langhendries, Jean-Paul Lehtimäki, Terho Leinonen, Jaakko T Li, Aihuali Lindi, Virpi Lowry, Estelle Bustamante, Mariona Medina-Gomez, Carolina Melbye, Mads Michaelsen, Kim F Morgen, Camilla S Mori, Trevor A Nielsen, Tenna RH Niinikoski, Harri Oldehinkel, Albertine J Pahkala, Katja Panoutsopoulou, Kalliope Pedersen, Oluf Pennell, Craig E Power, Christine Reijneveld, Sijmen A Rivadeneira, Fernando Simpson, Angela Sly, Peter D Stokholm, Jakob Teo, Kook K Thiering, Elisabeth Timpson, Nicholas J Uitterlinden, Andre G van Beijsterveldt, Catharina E. M van Schaik, Barbera D. C Vaudel, Marc Verduci, Elvira Vinding, Rebecca K Vogel, Mandy Zeggini, Eleftheria Sebert, Sylvain Lind, Mads V Brown, Christopher D Santa-Marina, Loreto Reischl, Eva Frithioff-Bøjsøe, Christine Meyre, David Wheeler, Eleanor Ong, Ken Nohr, Ellen A Vrijkotte, Tanja G. M Koppelman, Gerard H Plomin, Robert Njølstad, Pal R Dedoussis, George D Froguel, Philippe Sorensen, Thorkild I. A Jacobsson, Bo Freathy, Rachel M Zemel, Babette S Raitakari, Olli Vrijheid, Martine Feenstra, Bjarke Lyytikäinen, Leo-Pekka Snieder, Harold Kirsten, Holger Holt, Patrick G Heinrich, Joachim Widen, Elisabeth Sunyer, Jordi Boomsma, Dorret I Järvelin, Marjo-Riitta Köerner, Antje Davey Smith, George Holm, Jens-Christian Atalay, Mustafa Murray, Clare Bisgaard, Hans McCarthy, Mark I Early Growth Genetics Consortium Jaddoe, Vincent WV Grant, Struan FA Felix, Janine F
author_role	author
author2	Bradfield, Jonathan P Ahluwalia, Tarunveer S Curtin, John A Lakka, Timo A Grarup, Niels Scholz, Markus van der Most, Peter J Monnereau, Claire Stergiakouli, Evie Heiskala, Anni Horikoshi, Momoko Fedko, Iryna O Vilor-Tejedor, Natalia Cousminer, Diana L Standl, Marie Wang, Carol A Viikari, Jorma Geller, Frank iniguez, Carmen Pitkanen, Niina Chesi, Alessandra Bacelis, Jonas Yengo, Loic Torrent Quetglas, Maties Ntalla, Ioanna Helgeland, Øyvind Selzam, Saskia Vonk, Judith M Zafarmand, Mohammed H Heude, Barbara Farooqi, Ismaa Sadaf Alyass, Akram Beaumont, Robin N Have, Christian T Rzehak, Peter Bilbao, Jose Ramon Schnurr, Theresia M Barroso, Ines Bonnelykke, Klaus Beilin, Lawrence J Carstensen, Lisbeth Charles, Marie-Aline Chawes, Bo Clement, Karine Closa-Monasterolo, Ricardo Custovic, Adnan Eriksson, Johan G Escribano, Joaquin Groen-Blokhuis, Maria Grote, Veit Gruszfeld, Dariusz Hakonarson, Hakon Hansen, Torben Hattersley, Andrew T Hollensted, Mette Hottenga, Jouke-Jan Hyppönen, Elina Johansson, Stefan Joro, Raimo Kähönen, Mika Karhunen, Ville Kiess, Wieland Knight, Bridget A Koletzko, Berthold Küehnapfel, Andreas Landgraf, Kathrin Langhendries, Jean-Paul Lehtimäki, Terho Leinonen, Jaakko T Li, Aihuali Lindi, Virpi Lowry, Estelle Bustamante, Mariona Medina-Gomez, Carolina Melbye, Mads Michaelsen, Kim F Morgen, Camilla S Mori, Trevor A Nielsen, Tenna RH Niinikoski, Harri Oldehinkel, Albertine J Pahkala, Katja Panoutsopoulou, Kalliope Pedersen, Oluf Pennell, Craig E Power, Christine Reijneveld, Sijmen A Rivadeneira, Fernando Simpson, Angela Sly, Peter D Stokholm, Jakob Teo, Kook K Thiering, Elisabeth Timpson, Nicholas J Uitterlinden, Andre G van Beijsterveldt, Catharina E. M van Schaik, Barbera D. C Vaudel, Marc Verduci, Elvira Vinding, Rebecca K Vogel, Mandy Zeggini, Eleftheria Sebert, Sylvain Lind, Mads V Brown, Christopher D Santa-Marina, Loreto Reischl, Eva Frithioff-Bøjsøe, Christine Meyre, David Wheeler, Eleanor Ong, Ken Nohr, Ellen A Vrijkotte, Tanja G. M Koppelman, Gerard H Plomin, Robert Njølstad, Pal R Dedoussis, George D Froguel, Philippe Sorensen, Thorkild I. A Jacobsson, Bo Freathy, Rachel M Zemel, Babette S Raitakari, Olli Vrijheid, Martine Feenstra, Bjarke Lyytikäinen, Leo-Pekka Snieder, Harold Kirsten, Holger Holt, Patrick G Heinrich, Joachim Widen, Elisabeth Sunyer, Jordi Boomsma, Dorret I Järvelin, Marjo-Riitta Köerner, Antje Davey Smith, George Holm, Jens-Christian Atalay, Mustafa Murray, Clare Bisgaard, Hans McCarthy, Mark I Early Growth Genetics Consortium Jaddoe, Vincent WV Grant, Struan FA Felix, Janine F
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv	Índice de Masa Corporal Análisis de la Aleatorización Mendeliana Relación Cintura-Cadera Factores de Riesgo Cardiometabólico Predisposición Genética a la Enfermedad Femenino Ubiquitina-Proteína Ligasas Nedd4 Proteínas de Transporte de Monosacáridos Adolescente Masculino Menarquia Estudio de Asociación del Genoma Completo Preescolar Presión Sanguínea Humanos Diabetes Mellitus Tipo 2 Enfermedades Cardiovasculares Niño Adulto Cardiovascular Diseases Child Diabetes Mellitus, Type 2 Genetic Predisposition to Disease Cardiometabolic Risk Factors Adult Humans Mendelian Randomization Analysis Child, Preschool Adolescent Waist-Hip Ratio Blood Pressure Monosaccharide Transport Proteins Male Menarche Nedd4 Ubiquitin Protein Ligases Female Body Mass Index Genome-Wide Association Study
topic	Índice de Masa Corporal Análisis de la Aleatorización Mendeliana Relación Cintura-Cadera Factores de Riesgo Cardiometabólico Predisposición Genética a la Enfermedad Femenino Ubiquitina-Proteína Ligasas Nedd4 Proteínas de Transporte de Monosacáridos Adolescente Masculino Menarquia Estudio de Asociación del Genoma Completo Preescolar Presión Sanguínea Humanos Diabetes Mellitus Tipo 2 Enfermedades Cardiovasculares Niño Adulto Cardiovascular Diseases Child Diabetes Mellitus, Type 2 Genetic Predisposition to Disease Cardiometabolic Risk Factors Adult Humans Mendelian Randomization Analysis Child, Preschool Adolescent Waist-Hip Ratio Blood Pressure Monosaccharide Transport Proteins Male Menarche Nedd4 Ubiquitin Protein Ligases Female Body Mass Index Genome-Wide Association Study
description	The genetic background of childhood body mass index (BMI), and the extent to which the well-known associations of childhood BMI with adult diseases are explained by shared genetic factors, are largely unknown. We performed a genome-wide association study meta-analysis of BMI in 61,111 children aged between 2 and 10 years. Twenty-five independent loci reached genome-wide significance in the combined discovery and replication analyses. Two of these, located nearNEDD4LandSLC45A3, have not previously been reported in relation to either childhood or adult BMI. Positive genetic correlations of childhood BMI with birth weight and adult BMI, waist-to-hip ratio, diastolic blood pressure and type 2 diabetes were detected (R(g)ranging from 0.11 to 0.76, P-values <0.002). A negative genetic correlation of childhood BMI with age at menarche was observed. Our results suggest that the biological processes underlying childhood BMI largely, but not completely, overlap with those underlying adult BMI. The well-known observational associations of BMI in childhood with cardio-metabolic diseases in adulthood may reflect partial genetic overlap, but in light of previous evidence, it is also likely that they are explained through phenotypic continuity of BMI from childhood into adulthood. Author summary Although twin studies have shown that body mass index (BMI) is highly heritable, many common genetic variants involved in the development of BMI have not yet been identified, especially in children. We studied associations of more than 40 million genetic variants with childhood BMI in 61,111 children aged between 2 and 10 years. We identified 25 genetic variants that were associated with childhood BMI. Two of these have not been implicated for BMI previously, located close to the genesNEDD4LandSLC45A3. We also show that the genetic background of childhood BMI overlaps with that of birth weight, adult BMI, waist-to-hip-ratio, diastolic blood pressure, type 2 diabetes, and age at menarche. Our results suggest that the biological processes underlying childhood BMI largely overlap with those underlying adult BMI. However, the overlap is not complete. Additionally, the genetic backgrounds of childhood BMI and other cardio-metabolic phenotypes are overlapping. This may mean that the associations of childhood BMI and later cardio-metabolic outcomes are partially explained by shared genetics, but it could also be explained by the strong association of childhood BMI with adult BMI.
publishDate	2020
dc.date.none.fl_str_mv	2020 2020-10-01 2020 2020-10-01 2024 2024-09-13
dc.type.none.fl_str_mv	research article http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://hdl.handle.net/20.500.12105/23028
url	https://hdl.handle.net/20.500.12105/23028
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	Public Library of Science (PLOS)
publisher.none.fl_str_mv	Public Library of Science (PLOS)
dc.source.none.fl_str_mv	reponame:Repisalud instname:Instituto de Salud Carlos III (ISCIII)
instname_str	Instituto de Salud Carlos III (ISCIII)
reponame_str	Repisalud
collection	Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
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spelling	Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traitsVogelezang, SuzanneBradfield, Jonathan PAhluwalia, Tarunveer SCurtin, John ALakka, Timo AGrarup, NielsScholz, Markusvan der Most, Peter JMonnereau, ClaireStergiakouli, EvieHeiskala, AnniHorikoshi, MomokoFedko, Iryna OVilor-Tejedor, NataliaCousminer, Diana LStandl, MarieWang, Carol AViikari, JormaGeller, Frankiniguez, CarmenPitkanen, NiinaChesi, AlessandraBacelis, JonasYengo, LoicTorrent Quetglas, MatiesNtalla, IoannaHelgeland, ØyvindSelzam, SaskiaVonk, Judith MZafarmand, Mohammed HHeude, BarbaraFarooqi, Ismaa SadafAlyass, AkramBeaumont, Robin NHave, Christian TRzehak, PeterBilbao, Jose RamonSchnurr, Theresia MBarroso, InesBonnelykke, KlausBeilin, Lawrence JCarstensen, LisbethCharles, Marie-AlineChawes, BoClement, KarineClosa-Monasterolo, RicardoCustovic, AdnanEriksson, Johan GEscribano, JoaquinGroen-Blokhuis, MariaGrote, VeitGruszfeld, DariuszHakonarson, HakonHansen, TorbenHattersley, Andrew THollensted, MetteHottenga, Jouke-JanHyppönen, ElinaJohansson, StefanJoro, RaimoKähönen, MikaKarhunen, VilleKiess, WielandKnight, Bridget AKoletzko, BertholdKüehnapfel, AndreasLandgraf, KathrinLanghendries, Jean-PaulLehtimäki, TerhoLeinonen, Jaakko TLi, AihualiLindi, VirpiLowry, EstelleBustamante, MarionaMedina-Gomez, CarolinaMelbye, MadsMichaelsen, Kim FMorgen, Camilla SMori, Trevor ANielsen, Tenna RHNiinikoski, HarriOldehinkel, Albertine JPahkala, KatjaPanoutsopoulou, KalliopePedersen, OlufPennell, Craig EPower, ChristineReijneveld, Sijmen ARivadeneira, FernandoSimpson, AngelaSly, Peter DStokholm, JakobTeo, Kook KThiering, ElisabethTimpson, Nicholas JUitterlinden, Andre Gvan Beijsterveldt, Catharina E. Mvan Schaik, Barbera D. CVaudel, MarcVerduci, ElviraVinding, Rebecca KVogel, MandyZeggini, EleftheriaSebert, SylvainLind, Mads VBrown, Christopher DSanta-Marina, LoretoReischl, EvaFrithioff-Bøjsøe, ChristineMeyre, DavidWheeler, EleanorOng, KenNohr, Ellen AVrijkotte, Tanja G. MKoppelman, Gerard HPlomin, RobertNjølstad, Pal RDedoussis, George DFroguel, PhilippeSorensen, Thorkild I. AJacobsson, BoFreathy, Rachel MZemel, Babette SRaitakari, OlliVrijheid, MartineFeenstra, BjarkeLyytikäinen, Leo-PekkaSnieder, HaroldKirsten, HolgerHolt, Patrick GHeinrich, JoachimWiden, ElisabethSunyer, JordiBoomsma, Dorret IJärvelin, Marjo-RiittaKöerner, AntjeDavey Smith, GeorgeHolm, Jens-ChristianAtalay, MustafaMurray, ClareBisgaard, HansMcCarthy, Mark IEarly Growth Genetics ConsortiumJaddoe, Vincent WVGrant, Struan FAFelix, Janine FÍndice de Masa CorporalAnálisis de la Aleatorización MendelianaRelación Cintura-CaderaFactores de Riesgo CardiometabólicoPredisposición Genética a la EnfermedadFemeninoUbiquitina-Proteína Ligasas Nedd4Proteínas de Transporte de MonosacáridosAdolescenteMasculinoMenarquiaEstudio de Asociación del Genoma CompletoPreescolarPresión SanguíneaHumanosDiabetes Mellitus Tipo 2Enfermedades CardiovascularesNiñoAdultoCardiovascular DiseasesChildDiabetes Mellitus, Type 2Genetic Predisposition to DiseaseCardiometabolic Risk FactorsAdultHumansMendelian Randomization AnalysisChild, PreschoolAdolescentWaist-Hip RatioBlood PressureMonosaccharide Transport ProteinsMaleMenarcheNedd4 Ubiquitin Protein LigasesFemaleBody Mass IndexGenome-Wide Association StudyThe genetic background of childhood body mass index (BMI), and the extent to which the well-known associations of childhood BMI with adult diseases are explained by shared genetic factors, are largely unknown. We performed a genome-wide association study meta-analysis of BMI in 61,111 children aged between 2 and 10 years. Twenty-five independent loci reached genome-wide significance in the combined discovery and replication analyses. Two of these, located nearNEDD4LandSLC45A3, have not previously been reported in relation to either childhood or adult BMI. Positive genetic correlations of childhood BMI with birth weight and adult BMI, waist-to-hip ratio, diastolic blood pressure and type 2 diabetes were detected (R(g)ranging from 0.11 to 0.76, P-values <0.002). A negative genetic correlation of childhood BMI with age at menarche was observed. Our results suggest that the biological processes underlying childhood BMI largely, but not completely, overlap with those underlying adult BMI. The well-known observational associations of BMI in childhood with cardio-metabolic diseases in adulthood may reflect partial genetic overlap, but in light of previous evidence, it is also likely that they are explained through phenotypic continuity of BMI from childhood into adulthood. Author summary Although twin studies have shown that body mass index (BMI) is highly heritable, many common genetic variants involved in the development of BMI have not yet been identified, especially in children. We studied associations of more than 40 million genetic variants with childhood BMI in 61,111 children aged between 2 and 10 years. We identified 25 genetic variants that were associated with childhood BMI. Two of these have not been implicated for BMI previously, located close to the genesNEDD4LandSLC45A3. We also show that the genetic background of childhood BMI overlaps with that of birth weight, adult BMI, waist-to-hip-ratio, diastolic blood pressure, type 2 diabetes, and age at menarche. Our results suggest that the biological processes underlying childhood BMI largely overlap with those underlying adult BMI. However, the overlap is not complete. Additionally, the genetic backgrounds of childhood BMI and other cardio-metabolic phenotypes are overlapping. This may mean that the associations of childhood BMI and later cardio-metabolic outcomes are partially explained by shared genetics, but it could also be explained by the strong association of childhood BMI with adult BMI.Public Library of Science (PLOS)20242024-09-1320202020-10-0120202020-10-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articlehttps://hdl.handle.net/20.500.12105/23028reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/230282026-06-12T12:43:37Z
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Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits

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