The Anti-Cholinesterase Potential of Fifteen Different Species of Narcissus L. (Amaryllidaceae) Collected in Spain
<p>Narcissus L. is a renowned plant genus with a notable center of diversity and is primarily</p><p>located in the Mediterranean region. These plants are widely recognized for their ornamental value,</p><p>owing to the beauty of their flowers; nonetheless, they also hol...
| Autores: | , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2024 |
| País: | España |
| Institución: | Universidad de Barcelona |
| Repositorio: | Dipòsit Digital de la UB |
| OAI Identifier: | oai:diposit.ub.edu:2445/215976 |
| Acceso en línea: | https://hdl.handle.net/2445/215976 |
| Access Level: | acceso abierto |
| Palabra clave: | Amaril·lidàcies Alcaloides Malaltia d'Alzheimer Amaryllidaceae Alkaloids Alzheimer's disease |
| Sumario: | <p>Narcissus L. is a renowned plant genus with a notable center of diversity and is primarily</p><p>located in the Mediterranean region. These plants are widely recognized for their ornamental value,</p><p>owing to the beauty of their flowers; nonetheless, they also hold pharmacological importance. In</p><p>Europe, pharmaceutical companies usually use the bulbs of Narcissus pseudonarcissus cv. Carlton to</p><p>extract galanthamine, which is one of the few medications approved by the FDA for the palliative</p><p>treatment of mild-to-moderate symptoms of Alzheimer’s disease. The purpose of this study was to</p><p>evaluate the potential of these plants in Alzheimer’s disease. The alkaloid extract from the leaves</p><p>of different species of Narcissus was obtained by an acid-base extraction work-up -procedure. The</p><p>biological potential of the samples was carried out by evaluating their ability to inhibit the enzymes</p><p>acetyl- and butyrylcholinesterase (AChE and BuChE, respectively). The species N. jacetanus exhibited</p><p>the best inhibition values against AChE, with IC50 values of 0.75 0.03 gmL 1, while N. jonquilla</p><p>was the most active against BuChE, with IC50 values of 11.72 1.15 gmL 1.</p> |
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