Real-Time Polarimetry of Hyperpolarized 13C Nuclear Spins Using an Atomic Magnetometer

We introduce a method for nondestructive quantification of nuclear spin polarization, of relevance to hyperpolarized spin tracers widely used in magnetic resonance from spectroscopy to in vivo imaging. In a bias field of around 30 nT we use a high-sensitivity miniaturized 87Rb-vapor magnetometer to...

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Detalles Bibliográficos
Autores: Mouloudakis, K., Bodenstedt, S., Azagra, Marc, Mitchell, M. W., Marco Rius, Irene, Tayler, Michael C. D.
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2023
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/206206
Acceso en línea:https://hdl.handle.net/2445/206206
Access Level:acceso abierto
Palabra clave:Ressonància magnètica
Spin (Física nuclear)
Magnetic resonance
Nuclear spin
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spelling Real-Time Polarimetry of Hyperpolarized 13C Nuclear Spins Using an Atomic MagnetometerMouloudakis, K.Bodenstedt, S.Azagra, MarcMitchell, M. W.Marco Rius, IreneTayler, Michael C. D.Ressonància magnèticaSpin (Física nuclear)Magnetic resonanceNuclear spinWe introduce a method for nondestructive quantification of nuclear spin polarization, of relevance to hyperpolarized spin tracers widely used in magnetic resonance from spectroscopy to in vivo imaging. In a bias field of around 30 nT we use a high-sensitivity miniaturized 87Rb-vapor magnetometer to measure the field generated by the sample, as it is driven by a windowed dynamical decoupling pulse sequence that both maximizes the nuclear spin lifetime and modulates the polarization for easy detection. We demonstrate the procedure applied to a 0.08 M hyperpolarized [1-13C]-pyruvate solution produced by dissolution dynamic nuclear polarization, measuring polarization repeatedly during natural decay at Earth's field. Application to real-time and continuous quality monitoring of hyperpolarized substances is discussed.American Chemical Society2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://hdl.handle.net/2445/206206Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaIngléshttps://doi.org/10.1021/acs.jpclett.2c03864Journal Of Physical Chemistry Letters, 2023, vol. 14, num. 5, p. 1192-1197https://doi.org/10.1021/acs.jpclett.2c03864(c) American Chemical Society, 2023info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/2062062026-05-27T06:46:51Z
dc.title.none.fl_str_mv Real-Time Polarimetry of Hyperpolarized 13C Nuclear Spins Using an Atomic Magnetometer
title Real-Time Polarimetry of Hyperpolarized 13C Nuclear Spins Using an Atomic Magnetometer
spellingShingle Real-Time Polarimetry of Hyperpolarized 13C Nuclear Spins Using an Atomic Magnetometer
Mouloudakis, K.
Ressonància magnètica
Spin (Física nuclear)
Magnetic resonance
Nuclear spin
title_short Real-Time Polarimetry of Hyperpolarized 13C Nuclear Spins Using an Atomic Magnetometer
title_full Real-Time Polarimetry of Hyperpolarized 13C Nuclear Spins Using an Atomic Magnetometer
title_fullStr Real-Time Polarimetry of Hyperpolarized 13C Nuclear Spins Using an Atomic Magnetometer
title_full_unstemmed Real-Time Polarimetry of Hyperpolarized 13C Nuclear Spins Using an Atomic Magnetometer
title_sort Real-Time Polarimetry of Hyperpolarized 13C Nuclear Spins Using an Atomic Magnetometer
dc.creator.none.fl_str_mv Mouloudakis, K.
Bodenstedt, S.
Azagra, Marc
Mitchell, M. W.
Marco Rius, Irene
Tayler, Michael C. D.
author Mouloudakis, K.
author_facet Mouloudakis, K.
Bodenstedt, S.
Azagra, Marc
Mitchell, M. W.
Marco Rius, Irene
Tayler, Michael C. D.
author_role author
author2 Bodenstedt, S.
Azagra, Marc
Mitchell, M. W.
Marco Rius, Irene
Tayler, Michael C. D.
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Ressonància magnètica
Spin (Física nuclear)
Magnetic resonance
Nuclear spin
topic Ressonància magnètica
Spin (Física nuclear)
Magnetic resonance
Nuclear spin
description We introduce a method for nondestructive quantification of nuclear spin polarization, of relevance to hyperpolarized spin tracers widely used in magnetic resonance from spectroscopy to in vivo imaging. In a bias field of around 30 nT we use a high-sensitivity miniaturized 87Rb-vapor magnetometer to measure the field generated by the sample, as it is driven by a windowed dynamical decoupling pulse sequence that both maximizes the nuclear spin lifetime and modulates the polarization for easy detection. We demonstrate the procedure applied to a 0.08 M hyperpolarized [1-13C]-pyruvate solution produced by dissolution dynamic nuclear polarization, measuring polarization repeatedly during natural decay at Earth's field. Application to real-time and continuous quality monitoring of hyperpolarized substances is discussed.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/206206
url https://hdl.handle.net/2445/206206
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://doi.org/10.1021/acs.jpclett.2c03864
Journal Of Physical Chemistry Letters, 2023, vol. 14, num. 5, p. 1192-1197
https://doi.org/10.1021/acs.jpclett.2c03864
dc.rights.none.fl_str_mv (c) American Chemical Society, 2023
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) American Chemical Society, 2023
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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