Mitogen-Activated Protein Kinase Phosphatases (MKPs) in Fungal Signaling: Conservation, Function, and Regulation.

Mitogen-activated protein kinases (MAPKs) are key mediators of signaling in fungi, participating in the response to diverse stresses and in developmental processes. Since the precise regulation of MAPKs is fundamental for cell physiology, fungi bear dual specificity phosphatases (DUSPs) that act as...

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Detalles Bibliográficos
Autores: González Rubio, Gema, Fernández-Acero Bascones, Teresa, Martín, Humberto, Molina Martín, María
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/13375
Acceso en línea:https://hdl.handle.net/20.500.14352/13375
Access Level:acceso abierto
Palabra clave:579
576
Fungal MKPs
MAPKs
Signaling
Msg5
Sdp1
Pmp1
Cpp1
Biología molecular (Farmacia)
Microbiología (Farmacia)
3302.03 Microbiología Industrial
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oai_identifier_str oai:docta.ucm.es:20.500.14352/13375
network_acronym_str ES
network_name_str España
repository_id_str
spelling Mitogen-Activated Protein Kinase Phosphatases (MKPs) in Fungal Signaling: Conservation, Function, and Regulation.González Rubio, GemaFernández-Acero Bascones, TeresaMartín, HumbertoMolina Martín, María579576Fungal MKPsMAPKsSignalingMsg5Sdp1Pmp1Cpp1Biología molecular (Farmacia)Microbiología (Farmacia)3302.03 Microbiología IndustrialMitogen-activated protein kinases (MAPKs) are key mediators of signaling in fungi, participating in the response to diverse stresses and in developmental processes. Since the precise regulation of MAPKs is fundamental for cell physiology, fungi bear dual specificity phosphatases (DUSPs) that act as MAP kinase phosphatases (MKPs). Whereas fungal MKPs share characteristic domains of this phosphatase subfamily, they also have specific interaction motifs and particular activation mechanisms, which, for example, allow some yeast MKPs, such as Sdp1, to couple oxidative stress with substrate recognition. Model yeasts show that MKPs play a key role in the modulation of MAPK signaling flow. Mutants affected in Msg5 or in Pmp1 display MAPK hyperactivation and specific phenotypes. MKPs from virulent fungi, such as Cpp1, Msg5, and Pmp1, are relevant for pathogenicity. Apart from transcriptional regulation, MKPs can be post-transcriptionally regulated by RNA-binding proteins such as Rnc1, which stabilizes the mRNA. Pmp1 activity and Msg5 stability are regulated by phosphorylation and ubiquitination, respectively. Therefore, fungi offer a platform to gain insight into the regulatory mechanisms that control MKPs.MDPIUniversidad Complutense de Madrid20192019-04-0520192019-04-05journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/13375reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 3.0 Españahttps://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/133752026-06-02T12:44:21Z
dc.title.none.fl_str_mv Mitogen-Activated Protein Kinase Phosphatases (MKPs) in Fungal Signaling: Conservation, Function, and Regulation.
title Mitogen-Activated Protein Kinase Phosphatases (MKPs) in Fungal Signaling: Conservation, Function, and Regulation.
spellingShingle Mitogen-Activated Protein Kinase Phosphatases (MKPs) in Fungal Signaling: Conservation, Function, and Regulation.
González Rubio, Gema
579
576
Fungal MKPs
MAPKs
Signaling
Msg5
Sdp1
Pmp1
Cpp1
Biología molecular (Farmacia)
Microbiología (Farmacia)
3302.03 Microbiología Industrial
title_short Mitogen-Activated Protein Kinase Phosphatases (MKPs) in Fungal Signaling: Conservation, Function, and Regulation.
title_full Mitogen-Activated Protein Kinase Phosphatases (MKPs) in Fungal Signaling: Conservation, Function, and Regulation.
title_fullStr Mitogen-Activated Protein Kinase Phosphatases (MKPs) in Fungal Signaling: Conservation, Function, and Regulation.
title_full_unstemmed Mitogen-Activated Protein Kinase Phosphatases (MKPs) in Fungal Signaling: Conservation, Function, and Regulation.
title_sort Mitogen-Activated Protein Kinase Phosphatases (MKPs) in Fungal Signaling: Conservation, Function, and Regulation.
dc.creator.none.fl_str_mv González Rubio, Gema
Fernández-Acero Bascones, Teresa
Martín, Humberto
Molina Martín, María
author González Rubio, Gema
author_facet González Rubio, Gema
Fernández-Acero Bascones, Teresa
Martín, Humberto
Molina Martín, María
author_role author
author2 Fernández-Acero Bascones, Teresa
Martín, Humberto
Molina Martín, María
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 579
576
Fungal MKPs
MAPKs
Signaling
Msg5
Sdp1
Pmp1
Cpp1
Biología molecular (Farmacia)
Microbiología (Farmacia)
3302.03 Microbiología Industrial
topic 579
576
Fungal MKPs
MAPKs
Signaling
Msg5
Sdp1
Pmp1
Cpp1
Biología molecular (Farmacia)
Microbiología (Farmacia)
3302.03 Microbiología Industrial
description Mitogen-activated protein kinases (MAPKs) are key mediators of signaling in fungi, participating in the response to diverse stresses and in developmental processes. Since the precise regulation of MAPKs is fundamental for cell physiology, fungi bear dual specificity phosphatases (DUSPs) that act as MAP kinase phosphatases (MKPs). Whereas fungal MKPs share characteristic domains of this phosphatase subfamily, they also have specific interaction motifs and particular activation mechanisms, which, for example, allow some yeast MKPs, such as Sdp1, to couple oxidative stress with substrate recognition. Model yeasts show that MKPs play a key role in the modulation of MAPK signaling flow. Mutants affected in Msg5 or in Pmp1 display MAPK hyperactivation and specific phenotypes. MKPs from virulent fungi, such as Cpp1, Msg5, and Pmp1, are relevant for pathogenicity. Apart from transcriptional regulation, MKPs can be post-transcriptionally regulated by RNA-binding proteins such as Rnc1, which stabilizes the mRNA. Pmp1 activity and Msg5 stability are regulated by phosphorylation and ubiquitination, respectively. Therefore, fungi offer a platform to gain insight into the regulatory mechanisms that control MKPs.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-04-05
2019
2019-04-05
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/13375
url https://hdl.handle.net/20.500.14352/13375
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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