Ultra-high-performance liquid chromatography-atmospheric pressure ionization-tandem mass spectrometry method for the migration studies of primary aromatic amines from food contact materials

This work describes the development of an ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method for the determination of 23 primary aromatic amines (PAAs) that can potentially migrate from food contact materials. The chromatographic separation was performed in a...

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Autores: Arrizabalaga Larrañaga, Ane, De Juan De Juan, Pedro, Bressan, Claudia, Vázquez Espinosa, Mercedes, González de Peredo, Ana, Santos, Francisco Javier, Moyano, Encarnación
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universidad del País Vasco
Repositorio:Addi. Archivo Digital para la Docencia y la Investigación
OAI Identifier:oai:dnet:addi________::109bcedac59fec1aebad147fcd832167
Acceso en línea:http://hdl.handle.net/10810/78798
Access Level:acceso abierto
Palabra clave:primary aromatic amines
atmospheric pressure ionization
liquid chromatography-tandem mass spectrometry
atmospheric pressure chemical ionization
pentafuorophenylpropyl column
food contact materials
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spelling Ultra-high-performance liquid chromatography-atmospheric pressure ionization-tandem mass spectrometry method for the migration studies of primary aromatic amines from food contact materialsArrizabalaga Larrañaga, AneDe Juan De Juan, PedroBressan, ClaudiaVázquez Espinosa, MercedesGonzález de Peredo, AnaSantos, Francisco JavierMoyano, Encarnaciónprimary aromatic aminesatmospheric pressure ionizationliquid chromatography-tandem mass spectrometryatmospheric pressure chemical ionizationpentafuorophenylpropyl columnfood contact materialsThis work describes the development of an ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method for the determination of 23 primary aromatic amines (PAAs) that can potentially migrate from food contact materials. The chromatographic separation was performed in a pentafluorophenylpropyl (PFPP) column achieving the separation of all PAAs in less than 6.5 min using water to acetonitrile (0.1% acetic acid in both solvents) as mobile phase and a gradient elution. The feasibility of atmospheric pressure chemical ionization (APCI) and atmospheric pressure photoionization (APPI) was evaluated as alternative to electrospray ionization (ESI) for the analysis of PAAs. Results showed that for most of the compounds, better responses were obtained with APCI, which shows the advantage of being less susceptible to matrix effects. Tandem mass spectrometry (MS/MS) fragmentation studies of [M + H]+ allowed for the selection of the two most characteristic and abundant product ions of the 23 PAAs which led to the development of a selective and sensitive UHPLC-APCI-MS/MS method with limits of detection ranging from 0.2 to 2 μg kg−1. Moreover, intra-day and inter-day precisions of the method in terms of relative standard deviation (RSD%) were lower than 10% and 15%, while trueness as relative error was <15% for most of the compounds. The UHPLC-APCI-MS/MS method was applied to the analysis of twenty black Nylon kitchenware samples that were submitted to migration tests using food simulant B (3% acetic acid, w/v), and the presence of PAAs were detected in eighteen samples at concentrations above the legislated limit (2 μg kg−1 of food or food simulants).Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. This work was supported by the Spanish Ministry of Economy and Competitiveness under the project PGC2018–095013–B-I00 and the Agency for Administration of University and Research Grants (Government of Catalonia, Spain) under the project 2017SGR–310.Springer Nature202620262020info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10810/78798reponame:Addi. Archivo Digital para la Docencia y la Investigacióninstname:Universidad del País VascoInglésinfo:eu-repo/grantAgreement/MICIU/PGC2018–095013–B-I00/https://link.springer.com/article/10.1007/s00216-022-03946-3info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/4.0/© The Author(s) 2022. This article is licensed under a Creative Commons Attribution 4.0 International Licenseoai:dnet:addi________::109bcedac59fec1aebad147fcd8321672026-06-18T09:23:17Z
dc.title.none.fl_str_mv Ultra-high-performance liquid chromatography-atmospheric pressure ionization-tandem mass spectrometry method for the migration studies of primary aromatic amines from food contact materials
title Ultra-high-performance liquid chromatography-atmospheric pressure ionization-tandem mass spectrometry method for the migration studies of primary aromatic amines from food contact materials
spellingShingle Ultra-high-performance liquid chromatography-atmospheric pressure ionization-tandem mass spectrometry method for the migration studies of primary aromatic amines from food contact materials
Arrizabalaga Larrañaga, Ane
primary aromatic amines
atmospheric pressure ionization
liquid chromatography-tandem mass spectrometry
atmospheric pressure chemical ionization
pentafuorophenylpropyl column
food contact materials
title_short Ultra-high-performance liquid chromatography-atmospheric pressure ionization-tandem mass spectrometry method for the migration studies of primary aromatic amines from food contact materials
title_full Ultra-high-performance liquid chromatography-atmospheric pressure ionization-tandem mass spectrometry method for the migration studies of primary aromatic amines from food contact materials
title_fullStr Ultra-high-performance liquid chromatography-atmospheric pressure ionization-tandem mass spectrometry method for the migration studies of primary aromatic amines from food contact materials
title_full_unstemmed Ultra-high-performance liquid chromatography-atmospheric pressure ionization-tandem mass spectrometry method for the migration studies of primary aromatic amines from food contact materials
title_sort Ultra-high-performance liquid chromatography-atmospheric pressure ionization-tandem mass spectrometry method for the migration studies of primary aromatic amines from food contact materials
dc.creator.none.fl_str_mv Arrizabalaga Larrañaga, Ane
De Juan De Juan, Pedro
Bressan, Claudia
Vázquez Espinosa, Mercedes
González de Peredo, Ana
Santos, Francisco Javier
Moyano, Encarnación
author Arrizabalaga Larrañaga, Ane
author_facet Arrizabalaga Larrañaga, Ane
De Juan De Juan, Pedro
Bressan, Claudia
Vázquez Espinosa, Mercedes
González de Peredo, Ana
Santos, Francisco Javier
Moyano, Encarnación
author_role author
author2 De Juan De Juan, Pedro
Bressan, Claudia
Vázquez Espinosa, Mercedes
González de Peredo, Ana
Santos, Francisco Javier
Moyano, Encarnación
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv primary aromatic amines
atmospheric pressure ionization
liquid chromatography-tandem mass spectrometry
atmospheric pressure chemical ionization
pentafuorophenylpropyl column
food contact materials
topic primary aromatic amines
atmospheric pressure ionization
liquid chromatography-tandem mass spectrometry
atmospheric pressure chemical ionization
pentafuorophenylpropyl column
food contact materials
description This work describes the development of an ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method for the determination of 23 primary aromatic amines (PAAs) that can potentially migrate from food contact materials. The chromatographic separation was performed in a pentafluorophenylpropyl (PFPP) column achieving the separation of all PAAs in less than 6.5 min using water to acetonitrile (0.1% acetic acid in both solvents) as mobile phase and a gradient elution. The feasibility of atmospheric pressure chemical ionization (APCI) and atmospheric pressure photoionization (APPI) was evaluated as alternative to electrospray ionization (ESI) for the analysis of PAAs. Results showed that for most of the compounds, better responses were obtained with APCI, which shows the advantage of being less susceptible to matrix effects. Tandem mass spectrometry (MS/MS) fragmentation studies of [M + H]+ allowed for the selection of the two most characteristic and abundant product ions of the 23 PAAs which led to the development of a selective and sensitive UHPLC-APCI-MS/MS method with limits of detection ranging from 0.2 to 2 μg kg−1. Moreover, intra-day and inter-day precisions of the method in terms of relative standard deviation (RSD%) were lower than 10% and 15%, while trueness as relative error was <15% for most of the compounds. The UHPLC-APCI-MS/MS method was applied to the analysis of twenty black Nylon kitchenware samples that were submitted to migration tests using food simulant B (3% acetic acid, w/v), and the presence of PAAs were detected in eighteen samples at concentrations above the legislated limit (2 μg kg−1 of food or food simulants).
publishDate 2020
dc.date.none.fl_str_mv 2020
2026
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10810/78798
url http://hdl.handle.net/10810/78798
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/MICIU/PGC2018–095013–B-I00/
https://link.springer.com/article/10.1007/s00216-022-03946-3
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:Addi. Archivo Digital para la Docencia y la Investigación
instname:Universidad del País Vasco
instname_str Universidad del País Vasco
reponame_str Addi. Archivo Digital para la Docencia y la Investigación
collection Addi. Archivo Digital para la Docencia y la Investigación
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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