R-Ras GTPases Signaling Role in Myelin Neurodegenerative Diseases

© 2020 by the authors.

Detalles Bibliográficos
Autores: Alcover-Sanchez, Berta, Garcia-Martin, Gonzalo, Wandosell, Francisco, Cubelos, Beatriz
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/218473
Acceso en línea:http://hdl.handle.net/10261/218473
Access Level:acceso abierto
Palabra clave:Myelin
Oligodendrocyte
Neurodegeneration
PI3K/Akt/mTOR
ERK1/2-MAPK
Wnt/β-catenin
R-Ras
id ES_da403088eee5b9875f8e4d5cd14ecd46
oai_identifier_str oai:digital.csic.es:10261/218473
network_acronym_str ES
network_name_str España
repository_id_str
spelling R-Ras GTPases Signaling Role in Myelin Neurodegenerative DiseasesAlcover-Sanchez, BertaGarcia-Martin, GonzaloWandosell, FranciscoCubelos, BeatrizMyelinOligodendrocyteNeurodegenerationPI3K/Akt/mTORERK1/2-MAPKWnt/β-cateninR-Ras© 2020 by the authors.Myelination is required for fast and efficient synaptic transmission in vertebrates. In the central nervous system, oligodendrocytes are responsible for creating myelin sheaths that isolate and protect axons, even throughout adulthood. However, when myelin is lost, the failure of remyelination mechanisms can cause neurodegenerative myelin-associated pathologies. From oligodendrocyte progenitor cells to mature myelinating oligodendrocytes, myelination is a highly complex process that involves many elements of cellular signaling, yet many of the mechanisms that coordinate it, remain unknown. In this review, we will focus on the three major pathways involved in myelination (PI3K/Akt/mTOR, ERK1/2-MAPK, and Wnt/β-catenin) and recent advances describing the crosstalk elements which help to regulate them. In addition, we will review the tight relation between Ras GTPases and myelination processes and discuss its potential as novel elements of crosstalk between the pathways. A better understanding of the crosstalk elements orchestrating myelination mechanisms is essential to identify new potential targets to mitigate neurodegeneration.This work was supported by the Spanish Ministry of Economy and Competitiveness, Grant: RTI2018-096303B-C33.Peer reviewedMultidisciplinary Digital Publishing InstituteMinisterio de Ciencia, Innovación y Universidades (España)Agencia Estatal de Investigación (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2020202020202020info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/218473reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-096303B-C33RTI2018-096303B-C33/AEI/10.13039/501100011033https://doi.org/10.3390/ijms21165911Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2184732026-05-22T06:33:51Z
dc.title.none.fl_str_mv R-Ras GTPases Signaling Role in Myelin Neurodegenerative Diseases
title R-Ras GTPases Signaling Role in Myelin Neurodegenerative Diseases
spellingShingle R-Ras GTPases Signaling Role in Myelin Neurodegenerative Diseases
Alcover-Sanchez, Berta
Myelin
Oligodendrocyte
Neurodegeneration
PI3K/Akt/mTOR
ERK1/2-MAPK
Wnt/β-catenin
R-Ras
title_short R-Ras GTPases Signaling Role in Myelin Neurodegenerative Diseases
title_full R-Ras GTPases Signaling Role in Myelin Neurodegenerative Diseases
title_fullStr R-Ras GTPases Signaling Role in Myelin Neurodegenerative Diseases
title_full_unstemmed R-Ras GTPases Signaling Role in Myelin Neurodegenerative Diseases
title_sort R-Ras GTPases Signaling Role in Myelin Neurodegenerative Diseases
dc.creator.none.fl_str_mv Alcover-Sanchez, Berta
Garcia-Martin, Gonzalo
Wandosell, Francisco
Cubelos, Beatriz
author Alcover-Sanchez, Berta
author_facet Alcover-Sanchez, Berta
Garcia-Martin, Gonzalo
Wandosell, Francisco
Cubelos, Beatriz
author_role author
author2 Garcia-Martin, Gonzalo
Wandosell, Francisco
Cubelos, Beatriz
author2_role author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia, Innovación y Universidades (España)
Agencia Estatal de Investigación (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Myelin
Oligodendrocyte
Neurodegeneration
PI3K/Akt/mTOR
ERK1/2-MAPK
Wnt/β-catenin
R-Ras
topic Myelin
Oligodendrocyte
Neurodegeneration
PI3K/Akt/mTOR
ERK1/2-MAPK
Wnt/β-catenin
R-Ras
description © 2020 by the authors.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/218473
url http://hdl.handle.net/10261/218473
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-096303B-C33
RTI2018-096303B-C33/AEI/10.13039/501100011033
https://doi.org/10.3390/ijms21165911
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869421559566827520
score 15,812429

Similares en LA Referencia