Clinical Relevance of Tumour-Infiltrating Immune Cells in HER2-Negative Breast Cancer Treated with Neoadjuvant Therapy

Currently, therapy response cannot be accurately predicted in HER2-negative breast cancer (BC). Measuring stromal tumour-infiltrating lymphocytes (sTILs) and mediators of the tumour microenvironment and characterizing tumour-infiltrating immune cells (TIICs) may improve treatment response in the neo...

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Autores: Arqueros, Cristina|||0000-0003-1249-2324, Gallardo, Alberto|||0000-0002-2514-2027, Vidal, Silvia|||0000-0002-3909-6682, Osuna Gómez, Rubén|||0000-0003-2875-4405, Tibau Martorell, Ariadna|||0000-0003-0229-6987, Bell, Olga|||0009-0000-2858-6187, Ramon y Cajal, Teresa|||0000-0003-3490-3585, Lerma Puertas, Enrique|||0000-0001-7908-2747, Lobato-Delgado, Bárbara|||0000-0001-6218-5774, Salazar, Juliana|||0000-0002-3581-4499, Barnadas i Molins, Agustí|||0000-0002-0429-1349
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:291402
Acceso en línea:https://ddd.uab.cat/record/291402
https://dx.doi.org/urn:doi:10.3390/ijms25052627
Access Level:acceso abierto
Palabra clave:Breast cancer
Neoadjuvant chemotherapy
Stromal tumour-infiltrating lymphocytes
Tumour-infiltrating immune cells
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spelling Clinical Relevance of Tumour-Infiltrating Immune Cells in HER2-Negative Breast Cancer Treated with Neoadjuvant TherapyArqueros, Cristina|||0000-0003-1249-2324Gallardo, Alberto|||0000-0002-2514-2027Vidal, Silvia|||0000-0002-3909-6682Osuna Gómez, Rubén|||0000-0003-2875-4405Tibau Martorell, Ariadna|||0000-0003-0229-6987Bell, Olga|||0009-0000-2858-6187Ramon y Cajal, Teresa|||0000-0003-3490-3585Lerma Puertas, Enrique|||0000-0001-7908-2747Lobato-Delgado, Bárbara|||0000-0001-6218-5774Salazar, Juliana|||0000-0002-3581-4499Barnadas i Molins, Agustí|||0000-0002-0429-1349Breast cancerNeoadjuvant chemotherapyStromal tumour-infiltrating lymphocytesTumour-infiltrating immune cellsCurrently, therapy response cannot be accurately predicted in HER2-negative breast cancer (BC). Measuring stromal tumour-infiltrating lymphocytes (sTILs) and mediators of the tumour microenvironment and characterizing tumour-infiltrating immune cells (TIICs) may improve treatment response in the neoadjuvant setting. Tumour tissue and peripheral blood samples were retrospectively collected from 118 patients, and sTILs were evaluated. Circulating exosomes and myeloid-derived suppressor cells were determined by flow cytometry. TIICs markers (CD4, CD8, CD20, CD1a, and CD68) were assessed immunohistochemically. High sTILs were significantly associated with pathological complete response (pCR; p = 0.048) and event-free survival (EFS; p = 0.027). High-CD68 cells were significantly associated with pCR in triple-negative (TN, p = 0.027) and high-CD1a cells with EFS in luminal-B (p = 0.012) BC. Cluster analyses of TIICs revealed two groups of tumours (C1 and C2) that had different immune patterns and clinical outcomes. An immunoscore based on clinicopathological variables was developed to identify high risk (C1) or low-risk (C2) patients. Additionally, cluster analyses revealed two groups of tumours for both luminal-B and TNBC. Our findings support the association of sTILs with pCR and show an immunological component in a subset of patients with HER2-negative BC. Our immunoscore may be useful for future escalation or de-escalation treatments.Universitat Autònoma de Barcelona 22024-01-0120242024-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/291402https://dx.doi.org/urn:doi:10.3390/ijms25052627reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2914022026-06-06T12:50:31Z
dc.title.none.fl_str_mv Clinical Relevance of Tumour-Infiltrating Immune Cells in HER2-Negative Breast Cancer Treated with Neoadjuvant Therapy
title Clinical Relevance of Tumour-Infiltrating Immune Cells in HER2-Negative Breast Cancer Treated with Neoadjuvant Therapy
spellingShingle Clinical Relevance of Tumour-Infiltrating Immune Cells in HER2-Negative Breast Cancer Treated with Neoadjuvant Therapy
Arqueros, Cristina|||0000-0003-1249-2324
Breast cancer
Neoadjuvant chemotherapy
Stromal tumour-infiltrating lymphocytes
Tumour-infiltrating immune cells
title_short Clinical Relevance of Tumour-Infiltrating Immune Cells in HER2-Negative Breast Cancer Treated with Neoadjuvant Therapy
title_full Clinical Relevance of Tumour-Infiltrating Immune Cells in HER2-Negative Breast Cancer Treated with Neoadjuvant Therapy
title_fullStr Clinical Relevance of Tumour-Infiltrating Immune Cells in HER2-Negative Breast Cancer Treated with Neoadjuvant Therapy
title_full_unstemmed Clinical Relevance of Tumour-Infiltrating Immune Cells in HER2-Negative Breast Cancer Treated with Neoadjuvant Therapy
title_sort Clinical Relevance of Tumour-Infiltrating Immune Cells in HER2-Negative Breast Cancer Treated with Neoadjuvant Therapy
dc.creator.none.fl_str_mv Arqueros, Cristina|||0000-0003-1249-2324
Gallardo, Alberto|||0000-0002-2514-2027
Vidal, Silvia|||0000-0002-3909-6682
Osuna Gómez, Rubén|||0000-0003-2875-4405
Tibau Martorell, Ariadna|||0000-0003-0229-6987
Bell, Olga|||0009-0000-2858-6187
Ramon y Cajal, Teresa|||0000-0003-3490-3585
Lerma Puertas, Enrique|||0000-0001-7908-2747
Lobato-Delgado, Bárbara|||0000-0001-6218-5774
Salazar, Juliana|||0000-0002-3581-4499
Barnadas i Molins, Agustí|||0000-0002-0429-1349
author Arqueros, Cristina|||0000-0003-1249-2324
author_facet Arqueros, Cristina|||0000-0003-1249-2324
Gallardo, Alberto|||0000-0002-2514-2027
Vidal, Silvia|||0000-0002-3909-6682
Osuna Gómez, Rubén|||0000-0003-2875-4405
Tibau Martorell, Ariadna|||0000-0003-0229-6987
Bell, Olga|||0009-0000-2858-6187
Ramon y Cajal, Teresa|||0000-0003-3490-3585
Lerma Puertas, Enrique|||0000-0001-7908-2747
Lobato-Delgado, Bárbara|||0000-0001-6218-5774
Salazar, Juliana|||0000-0002-3581-4499
Barnadas i Molins, Agustí|||0000-0002-0429-1349
author_role author
author2 Gallardo, Alberto|||0000-0002-2514-2027
Vidal, Silvia|||0000-0002-3909-6682
Osuna Gómez, Rubén|||0000-0003-2875-4405
Tibau Martorell, Ariadna|||0000-0003-0229-6987
Bell, Olga|||0009-0000-2858-6187
Ramon y Cajal, Teresa|||0000-0003-3490-3585
Lerma Puertas, Enrique|||0000-0001-7908-2747
Lobato-Delgado, Bárbara|||0000-0001-6218-5774
Salazar, Juliana|||0000-0002-3581-4499
Barnadas i Molins, Agustí|||0000-0002-0429-1349
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv Breast cancer
Neoadjuvant chemotherapy
Stromal tumour-infiltrating lymphocytes
Tumour-infiltrating immune cells
topic Breast cancer
Neoadjuvant chemotherapy
Stromal tumour-infiltrating lymphocytes
Tumour-infiltrating immune cells
description Currently, therapy response cannot be accurately predicted in HER2-negative breast cancer (BC). Measuring stromal tumour-infiltrating lymphocytes (sTILs) and mediators of the tumour microenvironment and characterizing tumour-infiltrating immune cells (TIICs) may improve treatment response in the neoadjuvant setting. Tumour tissue and peripheral blood samples were retrospectively collected from 118 patients, and sTILs were evaluated. Circulating exosomes and myeloid-derived suppressor cells were determined by flow cytometry. TIICs markers (CD4, CD8, CD20, CD1a, and CD68) were assessed immunohistochemically. High sTILs were significantly associated with pathological complete response (pCR; p = 0.048) and event-free survival (EFS; p = 0.027). High-CD68 cells were significantly associated with pCR in triple-negative (TN, p = 0.027) and high-CD1a cells with EFS in luminal-B (p = 0.012) BC. Cluster analyses of TIICs revealed two groups of tumours (C1 and C2) that had different immune patterns and clinical outcomes. An immunoscore based on clinicopathological variables was developed to identify high risk (C1) or low-risk (C2) patients. Additionally, cluster analyses revealed two groups of tumours for both luminal-B and TNBC. Our findings support the association of sTILs with pCR and show an immunological component in a subset of patients with HER2-negative BC. Our immunoscore may be useful for future escalation or de-escalation treatments.
publishDate 2024
dc.date.none.fl_str_mv 2
2024-01-01
2024
2024-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/291402
https://dx.doi.org/urn:doi:10.3390/ijms25052627
url https://ddd.uab.cat/record/291402
https://dx.doi.org/urn:doi:10.3390/ijms25052627
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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