First-trimester maternal concentrations of polyfluoroalkyl substances and fetal growth throughout pregnancy

Background: Several studies have investigated the possible association between prenatal exposure to perfluoroalkyl substances (PFASs) and birth anthropometry. However, none has assessed fetal size longitudinally. We studied the possible association between PFASs and fetal biometry. Methods: In 1230...

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Autores: Costa, Olga, Iñiguez, Carmen, Manzano Salgado, Cyntia Beatriz, 1987-, Amiano, Pilar, Murcia, Mario, Casas Sanahuja, Maribel, Irizar, Amaia, Basterrechea, Mikel, Beneito, Andrea, Schettgen, Thomas, Sunyer Deu, Jordi, Vrijheid, Martine, Ballester Díez, Ferran, Lopez-Espinosa, Maria-José
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/43358
Acceso en línea:http://hdl.handle.net/10230/43358
http://dx.doi.org/10.1016/j.envint.2019.05.024
Access Level:acceso abierto
Palabra clave:Fetal growth
PFASs
PFHxS
PFNA
PFOA
PFOS
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spelling First-trimester maternal concentrations of polyfluoroalkyl substances and fetal growth throughout pregnancyCosta, OlgaIñiguez, CarmenManzano Salgado, Cyntia Beatriz, 1987-Amiano, PilarMurcia, MarioCasas Sanahuja, MaribelIrizar, AmaiaBasterrechea, MikelBeneito, AndreaSchettgen, ThomasSunyer Deu, JordiVrijheid, MartineBallester Díez, FerranLopez-Espinosa, Maria-JoséFetal growthPFASsPFHxSPFNAPFOAPFOSBackground: Several studies have investigated the possible association between prenatal exposure to perfluoroalkyl substances (PFASs) and birth anthropometry. However, none has assessed fetal size longitudinally. We studied the possible association between PFASs and fetal biometry. Methods: In 1230 mother-child pairs of three cohorts from the Spanish INMA-Project, we analyzed perfluorohexanesulfonic acid (PFHxS), perfluorooctanesulfonic acid (PFOS), perfluorooctanoic acid (PFOA), and perfluorononanoic acid (PFNA) in first-trimester maternal plasma (collection: 2003-2008). We measured abdominal circumference (AC), femur length (FL), biparietal diameter (BPD), and estimated fetal weight (EFW) by ultrasounds at 12, 20, and 34 gestational weeks. We conducted multivariable linear regression analyses between log2-transformed (PFASs) and SD-scores of fetal parameters in each cohort and subsequent meta-analysis. We also assessed effect modification by sex and maternal smoking. Results: PFHxS, PFOA, PFOS, and PFNA medians were: 0.58, 2.35, 6.05, and 0.65 ng/mL, respectively. There were no associations for the whole population in any trimester of pregnancy. However, we found an indication that maternal smoking modified the effect in different directions depending on the PFAS. Among smokers (31%), we found negative associations between both PFOA and PFNA and FL or EFW at week 20 (% change ranging between -6.8% and -5.7% per twofold PFAS increase) and positive associations between PFHxS or PFOS and BPD at week 34 (6.8% and 6.3%, respectively). Conclusions: Results did not suggest an overall association between prenatal PFASs and fetal growth. The results among smokers should be taken with caution and further studies are warranted to elucidate the possible role of smoking in this association.This work was supported by grants from the European Union [FP7-ENV-2011 cod 282957 and HEALTH.2010.2.4.5-1] and from Spain: Instituto de Salud Carlos III [Red INMA G03/176, CB06/02/0041, FIS-FEDER: PI03/1615, PI041436, PI04/1509, PI04/1112, PI04/1931, PI05/1079, PI05/1052, PI06/0867, PI06/1213, PI07/0314, PI081151, PI09/02647, PI09/00090, PI11/01007, PI11/02591, PI11/02038, PI12/01890, PI13/1944, PI13/2032, PI14/00891, PI14/01687, PI16/1288, and PI17/00663; Miguel Servet-FEDER CP11/0178, Miguel Servet-FSE: MS16/00128, and MSII16/00051; and PFIS-FI14/00099]; Alicia Koplowitz Foundation 2017; Generalitat Valenciana [FISABIO-UGP 15-230, 15-244, and 15-249]; Department of Health of the Basque Government [2005111093 and 2009111069]; the Provincial Government of Gipuzkoa [DFG06/004 and DFG08/001]; and the Generalitat de Catalunya-CIRIT [1999SGR 00241].Elsevier202020202019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/43358http://dx.doi.org/10.1016/j.envint.2019.05.024reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésEnvironment International. 2019;130:104830info:eu-repo/grantAgreement/EC/FP7/282957© 2019 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/)http://creativecommons.org/licenses/BY-NC-ND/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/433582026-06-12T07:21:37Z
dc.title.none.fl_str_mv First-trimester maternal concentrations of polyfluoroalkyl substances and fetal growth throughout pregnancy
title First-trimester maternal concentrations of polyfluoroalkyl substances and fetal growth throughout pregnancy
spellingShingle First-trimester maternal concentrations of polyfluoroalkyl substances and fetal growth throughout pregnancy
Costa, Olga
Fetal growth
PFASs
PFHxS
PFNA
PFOA
PFOS
title_short First-trimester maternal concentrations of polyfluoroalkyl substances and fetal growth throughout pregnancy
title_full First-trimester maternal concentrations of polyfluoroalkyl substances and fetal growth throughout pregnancy
title_fullStr First-trimester maternal concentrations of polyfluoroalkyl substances and fetal growth throughout pregnancy
title_full_unstemmed First-trimester maternal concentrations of polyfluoroalkyl substances and fetal growth throughout pregnancy
title_sort First-trimester maternal concentrations of polyfluoroalkyl substances and fetal growth throughout pregnancy
dc.creator.none.fl_str_mv Costa, Olga
Iñiguez, Carmen
Manzano Salgado, Cyntia Beatriz, 1987-
Amiano, Pilar
Murcia, Mario
Casas Sanahuja, Maribel
Irizar, Amaia
Basterrechea, Mikel
Beneito, Andrea
Schettgen, Thomas
Sunyer Deu, Jordi
Vrijheid, Martine
Ballester Díez, Ferran
Lopez-Espinosa, Maria-José
author Costa, Olga
author_facet Costa, Olga
Iñiguez, Carmen
Manzano Salgado, Cyntia Beatriz, 1987-
Amiano, Pilar
Murcia, Mario
Casas Sanahuja, Maribel
Irizar, Amaia
Basterrechea, Mikel
Beneito, Andrea
Schettgen, Thomas
Sunyer Deu, Jordi
Vrijheid, Martine
Ballester Díez, Ferran
Lopez-Espinosa, Maria-José
author_role author
author2 Iñiguez, Carmen
Manzano Salgado, Cyntia Beatriz, 1987-
Amiano, Pilar
Murcia, Mario
Casas Sanahuja, Maribel
Irizar, Amaia
Basterrechea, Mikel
Beneito, Andrea
Schettgen, Thomas
Sunyer Deu, Jordi
Vrijheid, Martine
Ballester Díez, Ferran
Lopez-Espinosa, Maria-José
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Fetal growth
PFASs
PFHxS
PFNA
PFOA
PFOS
topic Fetal growth
PFASs
PFHxS
PFNA
PFOA
PFOS
description Background: Several studies have investigated the possible association between prenatal exposure to perfluoroalkyl substances (PFASs) and birth anthropometry. However, none has assessed fetal size longitudinally. We studied the possible association between PFASs and fetal biometry. Methods: In 1230 mother-child pairs of three cohorts from the Spanish INMA-Project, we analyzed perfluorohexanesulfonic acid (PFHxS), perfluorooctanesulfonic acid (PFOS), perfluorooctanoic acid (PFOA), and perfluorononanoic acid (PFNA) in first-trimester maternal plasma (collection: 2003-2008). We measured abdominal circumference (AC), femur length (FL), biparietal diameter (BPD), and estimated fetal weight (EFW) by ultrasounds at 12, 20, and 34 gestational weeks. We conducted multivariable linear regression analyses between log2-transformed (PFASs) and SD-scores of fetal parameters in each cohort and subsequent meta-analysis. We also assessed effect modification by sex and maternal smoking. Results: PFHxS, PFOA, PFOS, and PFNA medians were: 0.58, 2.35, 6.05, and 0.65 ng/mL, respectively. There were no associations for the whole population in any trimester of pregnancy. However, we found an indication that maternal smoking modified the effect in different directions depending on the PFAS. Among smokers (31%), we found negative associations between both PFOA and PFNA and FL or EFW at week 20 (% change ranging between -6.8% and -5.7% per twofold PFAS increase) and positive associations between PFHxS or PFOS and BPD at week 34 (6.8% and 6.3%, respectively). Conclusions: Results did not suggest an overall association between prenatal PFASs and fetal growth. The results among smokers should be taken with caution and further studies are warranted to elucidate the possible role of smoking in this association.
publishDate 2019
dc.date.none.fl_str_mv 2019
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/43358
http://dx.doi.org/10.1016/j.envint.2019.05.024
url http://hdl.handle.net/10230/43358
http://dx.doi.org/10.1016/j.envint.2019.05.024
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Environment International. 2019;130:104830
info:eu-repo/grantAgreement/EC/FP7/282957
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/BY-NC-ND/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/BY-NC-ND/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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