Established and Emerging Roles of Epigenetic Regulation in Diabetic Cardiomyopathy

Karuna, Narainrit|||0000-0002-4050-7469; Matullo, Giuseppe; Devaux, Yvan|||0000-0002-5321-8543; Badimon, Lina|||0000-0002-9162-2459; Vilahur, Gemma|||0000-0002-2828-8873; Watson, Chris J.|||0000-0001-8749-0732; Russell-Hallinan, Adam; Lezoualc'h, Frank; Baker, Hana; Bernard, Monique; Rieusset, Jennifer; Derumeaux, Geneviève A.

Established and Emerging Roles of Epigenetic Regulation in Diabetic Cardiomyopathy

An increasing number of individuals are at high risk of type 2 diabetes (T2DM) and its cardiovascular (CV) complications, which challenges healthcare systems with an increased risk of developing CV diseases. Patients with T2DM exhibit a unique cardiac phenotype termed diabetic cardiomyopathy (DCM)....

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Autores:	Karuna, Narainrit\|\|\|0000-0002-4050-7469, Matullo, Giuseppe, Devaux, Yvan\|\|\|0000-0002-5321-8543, Badimon, Lina\|\|\|0000-0002-9162-2459, Vilahur, Gemma\|\|\|0000-0002-2828-8873, Watson, Chris J.\|\|\|0000-0001-8749-0732, Russell-Hallinan, Adam, Lezoualc'h, Frank, Baker, Hana, Bernard, Monique, Rieusset, Jennifer, Derumeaux, Geneviève A.
Tipo de recurso:	artículo
Fecha de publicación:	2025
País:	España
Institución:	Universitat Autònoma de Barcelona
Repositorio:	Dipòsit Digital de Documents de la UAB
Idioma:	inglés
OAI Identifier:	oai:dnet:uabarcelona_::00fd8b2e0f6422f102dcb62d4b0dce03
Acceso en línea:	https://ddd.uab.cat/record/328739 https://dx.doi.org/urn:doi:10.1002/dmrr.70081
Access Level:	acceso abierto
Palabra clave:	BET proteins DNA methylation circRNAs diabetic cardiomyopathy epigenetics epitranscriptomics histone modifications lncRNA miRNA

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spelling	Established and Emerging Roles of Epigenetic Regulation in Diabetic CardiomyopathyKaruna, Narainrit\|\|\|0000-0002-4050-7469Matullo, GiuseppeDevaux, Yvan\|\|\|0000-0002-5321-8543Badimon, Lina\|\|\|0000-0002-9162-2459Vilahur, Gemma\|\|\|0000-0002-2828-8873Watson, Chris J.\|\|\|0000-0001-8749-0732Russell-Hallinan, AdamLezoualc'h, FrankBaker, HanaBernard, MoniqueRieusset, JenniferDerumeaux, Geneviève A.BET proteinsDNA methylationcircRNAsdiabetic cardiomyopathyepigeneticsepitranscriptomicshistone modificationslncRNAmiRNAAn increasing number of individuals are at high risk of type 2 diabetes (T2DM) and its cardiovascular (CV) complications, which challenges healthcare systems with an increased risk of developing CV diseases. Patients with T2DM exhibit a unique cardiac phenotype termed diabetic cardiomyopathy (DCM). DCM usually involves complex and multifactorial pathogenic drivers, including myocardial inflammation, fibrosis, hypertrophy, and early diastolic dysfunction, which potentially evolve into systolic dysfunction and heart failure. There is a lack of effective treatments for DCM on the basis of the complexity of the disease per se and poor understanding of the mechanisms behind disease development and progression. Despite the considerable research attention on the onset of DCM development and progression, understanding of the full spectrum of pathogenic mechanisms has not yet been fully deciphered. Epigenetic alterations, including DNA methylation, histone modifications, bromodomain extra-terminal (BET)-containing reader proteins, and RNA-based mechanisms (e.g., miRs, lncRNAs, circRNA), are significantly associated with the initiation and evolution of DCM, particularly in the early stage. In this review, we provide insights into the evidence of epigenetic alterations related to DCM development and progression characteristics. Furthermore, the uniqueness of epigenetic changes in DCM in specific cell types within diabetic hearts is discussed. We also review epigenetic cooperation in the context of DCM development and epigenetic biomarkers related to DCM progression. With recent advancements in technology, epitranscriptomics-related to DCM has been uniquely discussed. Finally, this review may provide new avenues for potential implications for future research and the discovery of novel treatment targets for preventing the onset and progression of DCM.Universitat Autònoma de Barcelona. Departament de Medicina 22025-01-0120252025-01-01Article de revisióhttp://purl.org/coar/resource_type/c_dcae04bcVoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/328739https://dx.doi.org/urn:doi:10.1002/dmrr.70081reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:dnet:uabarcelona_::00fd8b2e0f6422f102dcb62d4b0dce032026-06-06T12:50:31Z
dc.title.none.fl_str_mv	Established and Emerging Roles of Epigenetic Regulation in Diabetic Cardiomyopathy
title	Established and Emerging Roles of Epigenetic Regulation in Diabetic Cardiomyopathy
spellingShingle	Established and Emerging Roles of Epigenetic Regulation in Diabetic Cardiomyopathy Karuna, Narainrit\|\|\|0000-0002-4050-7469 BET proteins DNA methylation circRNAs diabetic cardiomyopathy epigenetics epitranscriptomics histone modifications lncRNA miRNA
title_short	Established and Emerging Roles of Epigenetic Regulation in Diabetic Cardiomyopathy
title_full	Established and Emerging Roles of Epigenetic Regulation in Diabetic Cardiomyopathy
title_fullStr	Established and Emerging Roles of Epigenetic Regulation in Diabetic Cardiomyopathy
title_full_unstemmed	Established and Emerging Roles of Epigenetic Regulation in Diabetic Cardiomyopathy
title_sort	Established and Emerging Roles of Epigenetic Regulation in Diabetic Cardiomyopathy
dc.creator.none.fl_str_mv	Karuna, Narainrit\|\|\|0000-0002-4050-7469 Matullo, Giuseppe Devaux, Yvan\|\|\|0000-0002-5321-8543 Badimon, Lina\|\|\|0000-0002-9162-2459 Vilahur, Gemma\|\|\|0000-0002-2828-8873 Watson, Chris J.\|\|\|0000-0001-8749-0732 Russell-Hallinan, Adam Lezoualc'h, Frank Baker, Hana Bernard, Monique Rieusset, Jennifer Derumeaux, Geneviève A.
author	Karuna, Narainrit\|\|\|0000-0002-4050-7469
author_facet	Karuna, Narainrit\|\|\|0000-0002-4050-7469 Matullo, Giuseppe Devaux, Yvan\|\|\|0000-0002-5321-8543 Badimon, Lina\|\|\|0000-0002-9162-2459 Vilahur, Gemma\|\|\|0000-0002-2828-8873 Watson, Chris J.\|\|\|0000-0001-8749-0732 Russell-Hallinan, Adam Lezoualc'h, Frank Baker, Hana Bernard, Monique Rieusset, Jennifer Derumeaux, Geneviève A.
author_role	author
author2	Matullo, Giuseppe Devaux, Yvan\|\|\|0000-0002-5321-8543 Badimon, Lina\|\|\|0000-0002-9162-2459 Vilahur, Gemma\|\|\|0000-0002-2828-8873 Watson, Chris J.\|\|\|0000-0001-8749-0732 Russell-Hallinan, Adam Lezoualc'h, Frank Baker, Hana Bernard, Monique Rieusset, Jennifer Derumeaux, Geneviève A.
author2_role	author author author author author author author author author author author
dc.contributor.none.fl_str_mv	Universitat Autònoma de Barcelona. Departament de Medicina
dc.subject.none.fl_str_mv	BET proteins DNA methylation circRNAs diabetic cardiomyopathy epigenetics epitranscriptomics histone modifications lncRNA miRNA
topic	BET proteins DNA methylation circRNAs diabetic cardiomyopathy epigenetics epitranscriptomics histone modifications lncRNA miRNA
description	An increasing number of individuals are at high risk of type 2 diabetes (T2DM) and its cardiovascular (CV) complications, which challenges healthcare systems with an increased risk of developing CV diseases. Patients with T2DM exhibit a unique cardiac phenotype termed diabetic cardiomyopathy (DCM). DCM usually involves complex and multifactorial pathogenic drivers, including myocardial inflammation, fibrosis, hypertrophy, and early diastolic dysfunction, which potentially evolve into systolic dysfunction and heart failure. There is a lack of effective treatments for DCM on the basis of the complexity of the disease per se and poor understanding of the mechanisms behind disease development and progression. Despite the considerable research attention on the onset of DCM development and progression, understanding of the full spectrum of pathogenic mechanisms has not yet been fully deciphered. Epigenetic alterations, including DNA methylation, histone modifications, bromodomain extra-terminal (BET)-containing reader proteins, and RNA-based mechanisms (e.g., miRs, lncRNAs, circRNA), are significantly associated with the initiation and evolution of DCM, particularly in the early stage. In this review, we provide insights into the evidence of epigenetic alterations related to DCM development and progression characteristics. Furthermore, the uniqueness of epigenetic changes in DCM in specific cell types within diabetic hearts is discussed. We also review epigenetic cooperation in the context of DCM development and epigenetic biomarkers related to DCM progression. With recent advancements in technology, epitranscriptomics-related to DCM has been uniquely discussed. Finally, this review may provide new avenues for potential implications for future research and the discovery of novel treatment targets for preventing the onset and progression of DCM.
publishDate	2025
dc.date.none.fl_str_mv	2 2025-01-01 2025 2025-01-01
dc.type.none.fl_str_mv	Article de revisió http://purl.org/coar/resource_type/c_dcae04bc VoR http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://ddd.uab.cat/record/328739 https://dx.doi.org/urn:doi:10.1002/dmrr.70081
url	https://ddd.uab.cat/record/328739 https://dx.doi.org/urn:doi:10.1002/dmrr.70081
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.source.none.fl_str_mv	reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona
instname_str	Universitat Autònoma de Barcelona
reponame_str	Dipòsit Digital de Documents de la UAB
collection	Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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Established and Emerging Roles of Epigenetic Regulation in Diabetic Cardiomyopathy

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