Current insights into antibiotic resistance in uropathogenic Escherichia coli and interventions using selected bioactive phytochemicals
Uropathogenic Escherichia coli (UPEC) is the leading cause of urinary tract infections (UTIs) and a major contributor to the global antimicrobial resistance crisis. The increasing prevalence of multidrug-resistant (MDR) strains, including expanded-spectrum β-lactamases (ESBL) and carbapenemase-produ...
| Autores: | , , , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | TecnoCampus |
| Repositorio: | Repositori Digital del TecnoCampus |
| OAI Identifier: | oai:dnet:rdtecnocamp_::5743f2eb2f8ad3457a520d99257c7914 |
| Acceso en línea: | https://hdl.handle.net/20.500.12367/3237 |
| Access Level: | acceso abierto |
| Palabra clave: | Uropathogenic Escherichia coli Urinary tract infections Antibiotic resistance Phytochemicals Complementary therapies Efflux pump Biofilm |
| Sumario: | Uropathogenic Escherichia coli (UPEC) is the leading cause of urinary tract infections (UTIs) and a major contributor to the global antimicrobial resistance crisis. The increasing prevalence of multidrug-resistant (MDR) strains, including expanded-spectrum β-lactamases (ESBL) and carbapenemase-producing isolates, severely limits treatment options. This review provides an overview on the key molecular mechanisms of UPEC antibiotic resistance, such as enzymatic inactivation, target-site mutations, efflux pump activity, and biofilm formation. Beyond conventional antibiotics, special emphasis is placed on phytochemical strategies as promising alternatives. Flavonoids, alkaloids, terpenoids, and essential oils exhibit antibacterial, anti-adhesive, and antibiofilm properties. These natural bioactive compounds modulate motility, suppress fimbrial expression, inhibit quorum sensing, and enhance antibiotic efficacy, acting both as standalone agents and as adjuvants. [...] |
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