The Default Mode Network is functionally and structurally disrupted in amnestic mild cognitive impairment - A bimodal MEG-DTI study

Over the past years, several studies on Mild Cognitive Impairment (MCI) and Alzheimer's disease (AD) have reported Default Mode Network (DMN) deficits. This network is attracting increasing interest in the AD community, as it seems to play an important role in cognitive functioning and in beta...

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Detalles Bibliográficos
Autores: Garcés López, Maria Pilar, Pineda Pardo, José Ángel, Canuet, Leónides, Aurtenetxe, Sara, López, María Eugenia, Marcos, Alberto, Yus, Miguel, Llanero Luque, Marcos, Pozo, Francisco del, Sancho Ruíz, Miguel, Maestú Unturbe, Fernando
Tipo de recurso: artículo
Fecha de publicación:2014
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/34005
Acceso en línea:https://hdl.handle.net/20.500.14352/34005
Access Level:acceso abierto
Palabra clave:537
Resting-state networks
Independent component analysis
Alzheimers-disease
White-matter
Amyloid-beta
Alpha oscillations
Connectivity
Brain
Eeg
Magnetoencephalography.
Electricidad
Electrónica (Física)
2202.03 Electricidad
Descripción
Sumario:Over the past years, several studies on Mild Cognitive Impairment (MCI) and Alzheimer's disease (AD) have reported Default Mode Network (DMN) deficits. This network is attracting increasing interest in the AD community, as it seems to play an important role in cognitive functioning and in beta amyloid deposition. Attention has been particularly drawn to how different DMN regions are connected using functional or structural connectivity. To this end, most studies have used functional Magnetic Resonance Imaging (fMRI), Positron Emission Tomography (PET) or Diffusion Tensor Imaging (DTI). In this study we evaluated (1) functional connectivity from resting state magnetoencephalography (MEG) and (2) structural connectivity from DTI in 26 MCI patients and 31 age-matched controls. Compared to controls, the DMN in the MCI group was functionally disrupted in the alpha band, while no differences were found for delta, theta, beta and gamma frequency bands. In addition, structural disconnection could be assessed through a decreased fractional anisotropy along tracts connecting different DMN regions. This suggests that the DMN functional and anatomical disconnection could represent a core feature of MCI. (C) 2014 The Authors. Published by Elsevier Inc.

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