Low and Oscillatory Wall Shear Stress Is Not Related to Aortic Dilation in Patients With Bicuspid Aortic Valve

Supplemental Digital Content is available in the text. To assess the relationship between regional wall shear stress (WSS) and oscillatory shear index (OSI) and aortic dilation in patients with bicuspid aortic valve (BAV). Forty-six consecutive patients with BAV (63% with right-left-coronary-cusp fu...

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Autores: Dux-Santoy, Lydia|||0000-0001-8736-2095, Guala, Andrea|||0000-0002-5006-8164, Sotelo, Julio, Uribe, Sergio, Teixido-Tura, Gisela|||0000-0003-4714-2420, Ruiz Muñoz, Aroa|||0000-0002-1138-8528, Hurtado, Daniel E., Valente, Filipa|||0000-0002-5569-3292, Galian-Gay, Laura|||0000-0001-6828-5928, Gutiérrez García-Moreno, Laura, González-Alujas, Teresa, Johnson, Kevin M., Wieben, Oliver, Ferreira-Gonzalez, Ignacio|||0000-0002-1208-5561, Evangelista Masip, Arturo|||0000-0001-8182-1174, Rodríguez Palomares, José F.|||0000-0002-7229-9780
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:235412
Acceso en línea:https://ddd.uab.cat/record/235412
https://dx.doi.org/urn:doi:10.1161/ATVBAHA.119.313636
Access Level:acceso abierto
Palabra clave:Aorta
Bicuspid aortic valve
Magnetic resonance imaging
Mechanical stress
Regional blood flow
Thoracic aortic aneurysm
Vascular remodeling
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spelling Low and Oscillatory Wall Shear Stress Is Not Related to Aortic Dilation in Patients With Bicuspid Aortic ValveDux-Santoy, Lydia|||0000-0001-8736-2095Guala, Andrea|||0000-0002-5006-8164Sotelo, JulioUribe, SergioTeixido-Tura, Gisela|||0000-0003-4714-2420Ruiz Muñoz, Aroa|||0000-0002-1138-8528Hurtado, Daniel E.Valente, Filipa|||0000-0002-5569-3292Galian-Gay, Laura|||0000-0001-6828-5928Gutiérrez García-Moreno, LauraGonzález-Alujas, TeresaJohnson, Kevin M.Wieben, OliverFerreira-Gonzalez, Ignacio|||0000-0002-1208-5561Evangelista Masip, Arturo|||0000-0001-8182-1174Rodríguez Palomares, José F.|||0000-0002-7229-9780AortaBicuspid aortic valveMagnetic resonance imagingMechanical stressRegional blood flowThoracic aortic aneurysmVascular remodelingSupplemental Digital Content is available in the text. To assess the relationship between regional wall shear stress (WSS) and oscillatory shear index (OSI) and aortic dilation in patients with bicuspid aortic valve (BAV). Forty-six consecutive patients with BAV (63% with right-left-coronary-cusp fusion, aortic diameter ≤ 45 mm and no severe valvular disease) and 44 healthy volunteers were studied by time-resolved 3-dimensional phase-contrast magnetic resonance imaging. WSS and OSI were quantified at different levels of the ascending aorta and the aortic arch, and regional WSS and OSI maps were obtained. Seventy percent of BAV had ascending aorta dilation. Compared with healthy volunteers, patients with BAV had increased WSS and decreased OSI in most of the ascending aorta and the aortic arch. In both BAV and healthy volunteers, regions of high WSS matched regions of low OSI and vice versa. No regions of both low WSS and high OSI were identified in BAV compared with healthy volunteers. Patients with BAV with dilated compared with nondilated aorta presented low and oscillatory WSS in the aortic arch, but not in the ascending aorta where dilation is more prevalent. Furthermore, no regions of concomitant low WSS and high OSI were identified when BAV were compared according to leaflet fusion pattern, despite the well-known differences in regional dilation prevalence. Regions with low WSS and high OSI do not match those with the highest prevalence of dilation in patients with BAV, thus providing no evidence to support the low and oscillatory shear stress theory in the pathogenesis of proximal aorta dilation in the presence of BAV.Universitat Autònoma de Barcelona 22019-01-0120192019-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/235412https://dx.doi.org/urn:doi:10.1161/ATVBAHA.119.313636reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengMinisterio de Economía y Competitividad https://doi.org/10.13039/501100003329 RTC-2016-5152-1Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI14/0106Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI17/00381open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2354122026-06-06T12:50:31Z
dc.title.none.fl_str_mv Low and Oscillatory Wall Shear Stress Is Not Related to Aortic Dilation in Patients With Bicuspid Aortic Valve
title Low and Oscillatory Wall Shear Stress Is Not Related to Aortic Dilation in Patients With Bicuspid Aortic Valve
spellingShingle Low and Oscillatory Wall Shear Stress Is Not Related to Aortic Dilation in Patients With Bicuspid Aortic Valve
Dux-Santoy, Lydia|||0000-0001-8736-2095
Aorta
Bicuspid aortic valve
Magnetic resonance imaging
Mechanical stress
Regional blood flow
Thoracic aortic aneurysm
Vascular remodeling
title_short Low and Oscillatory Wall Shear Stress Is Not Related to Aortic Dilation in Patients With Bicuspid Aortic Valve
title_full Low and Oscillatory Wall Shear Stress Is Not Related to Aortic Dilation in Patients With Bicuspid Aortic Valve
title_fullStr Low and Oscillatory Wall Shear Stress Is Not Related to Aortic Dilation in Patients With Bicuspid Aortic Valve
title_full_unstemmed Low and Oscillatory Wall Shear Stress Is Not Related to Aortic Dilation in Patients With Bicuspid Aortic Valve
title_sort Low and Oscillatory Wall Shear Stress Is Not Related to Aortic Dilation in Patients With Bicuspid Aortic Valve
dc.creator.none.fl_str_mv Dux-Santoy, Lydia|||0000-0001-8736-2095
Guala, Andrea|||0000-0002-5006-8164
Sotelo, Julio
Uribe, Sergio
Teixido-Tura, Gisela|||0000-0003-4714-2420
Ruiz Muñoz, Aroa|||0000-0002-1138-8528
Hurtado, Daniel E.
Valente, Filipa|||0000-0002-5569-3292
Galian-Gay, Laura|||0000-0001-6828-5928
Gutiérrez García-Moreno, Laura
González-Alujas, Teresa
Johnson, Kevin M.
Wieben, Oliver
Ferreira-Gonzalez, Ignacio|||0000-0002-1208-5561
Evangelista Masip, Arturo|||0000-0001-8182-1174
Rodríguez Palomares, José F.|||0000-0002-7229-9780
author Dux-Santoy, Lydia|||0000-0001-8736-2095
author_facet Dux-Santoy, Lydia|||0000-0001-8736-2095
Guala, Andrea|||0000-0002-5006-8164
Sotelo, Julio
Uribe, Sergio
Teixido-Tura, Gisela|||0000-0003-4714-2420
Ruiz Muñoz, Aroa|||0000-0002-1138-8528
Hurtado, Daniel E.
Valente, Filipa|||0000-0002-5569-3292
Galian-Gay, Laura|||0000-0001-6828-5928
Gutiérrez García-Moreno, Laura
González-Alujas, Teresa
Johnson, Kevin M.
Wieben, Oliver
Ferreira-Gonzalez, Ignacio|||0000-0002-1208-5561
Evangelista Masip, Arturo|||0000-0001-8182-1174
Rodríguez Palomares, José F.|||0000-0002-7229-9780
author_role author
author2 Guala, Andrea|||0000-0002-5006-8164
Sotelo, Julio
Uribe, Sergio
Teixido-Tura, Gisela|||0000-0003-4714-2420
Ruiz Muñoz, Aroa|||0000-0002-1138-8528
Hurtado, Daniel E.
Valente, Filipa|||0000-0002-5569-3292
Galian-Gay, Laura|||0000-0001-6828-5928
Gutiérrez García-Moreno, Laura
González-Alujas, Teresa
Johnson, Kevin M.
Wieben, Oliver
Ferreira-Gonzalez, Ignacio|||0000-0002-1208-5561
Evangelista Masip, Arturo|||0000-0001-8182-1174
Rodríguez Palomares, José F.|||0000-0002-7229-9780
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv Aorta
Bicuspid aortic valve
Magnetic resonance imaging
Mechanical stress
Regional blood flow
Thoracic aortic aneurysm
Vascular remodeling
topic Aorta
Bicuspid aortic valve
Magnetic resonance imaging
Mechanical stress
Regional blood flow
Thoracic aortic aneurysm
Vascular remodeling
description Supplemental Digital Content is available in the text. To assess the relationship between regional wall shear stress (WSS) and oscillatory shear index (OSI) and aortic dilation in patients with bicuspid aortic valve (BAV). Forty-six consecutive patients with BAV (63% with right-left-coronary-cusp fusion, aortic diameter ≤ 45 mm and no severe valvular disease) and 44 healthy volunteers were studied by time-resolved 3-dimensional phase-contrast magnetic resonance imaging. WSS and OSI were quantified at different levels of the ascending aorta and the aortic arch, and regional WSS and OSI maps were obtained. Seventy percent of BAV had ascending aorta dilation. Compared with healthy volunteers, patients with BAV had increased WSS and decreased OSI in most of the ascending aorta and the aortic arch. In both BAV and healthy volunteers, regions of high WSS matched regions of low OSI and vice versa. No regions of both low WSS and high OSI were identified in BAV compared with healthy volunteers. Patients with BAV with dilated compared with nondilated aorta presented low and oscillatory WSS in the aortic arch, but not in the ascending aorta where dilation is more prevalent. Furthermore, no regions of concomitant low WSS and high OSI were identified when BAV were compared according to leaflet fusion pattern, despite the well-known differences in regional dilation prevalence. Regions with low WSS and high OSI do not match those with the highest prevalence of dilation in patients with BAV, thus providing no evidence to support the low and oscillatory shear stress theory in the pathogenesis of proximal aorta dilation in the presence of BAV.
publishDate 2019
dc.date.none.fl_str_mv 2
2019-01-01
2019
2019-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/235412
https://dx.doi.org/urn:doi:10.1161/ATVBAHA.119.313636
url https://ddd.uab.cat/record/235412
https://dx.doi.org/urn:doi:10.1161/ATVBAHA.119.313636
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 RTC-2016-5152-1
Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI14/0106
Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI17/00381
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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