Introduction: How evident is the evidence?

Randomized controlled trials (RCTs) and meta-analyses are the pinnacle of evidence-based medicine, enabling identification of the best available diagnostic, interventional, and therapeutic options. These tools help clinicians and policy makers to set clinical guidelines, but they also represent a do...

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Detalles Bibliográficos
Autor: Simon, Carlos
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:INCLIVA
Repositorio:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
OAI Identifier:oai:incliva.fundanetsuite.com:p4666
Acceso en línea:https://incliva.portalinvestigacion.com/publicaciones/4666
Access Level:acceso abierto
Palabra clave:Randomized controlled trials
meta-analysis
reproductive medicine
evidence
research integrity
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spelling Introduction: How evident is the evidence?Simon, CarlosRandomized controlled trialsmeta-analysisreproductive medicineevidenceresearch integrityRandomized controlled trials (RCTs) and meta-analyses are the pinnacle of evidence-based medicine, enabling identification of the best available diagnostic, interventional, and therapeutic options. These tools help clinicians and policy makers to set clinical guidelines, but they also represent a double-edged sword: The meaningfulness of RCTs and meta-analyses relies on their quality, performance, and integrity. This Views and Reviews collection prepared by 18 renowned experts and coordinated by Ben Mol aims to inform and educate our readers about RCTs and meta-analyses in reproductive medicine. The collection begins with the basic features that guarantee the quality of a trial, including protocols, registrations and monitoring, study design/analysis, and reporting standards. Next are discussed the status of planning and coordination of RCTs in different global settings, current unmet needs, and how future studies can better meet these needs, as well as methodologic issues facing different types of RCTs. Finally, we provide insight into the issue of data fabrication and falsification, offering possible solutions to ensure the integrity of RCTs. The challenges and benefits of these crucial evidence-generating tools deserve our attention and education because the findings of RCTs and meta-analyses can directly affect the health of our patients, and when performance and integrity problems exist, the "magic" of these tools disappears-with harmful consequences. Copyright © 2020 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.ELSEVIER SCIENCE INC2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://incliva.portalinvestigacion.com/publicaciones/4666FERTILITY AND STERILITYISSN: 00150282ISSNe: 15565653reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVAinstname:INCLIVAInglésinfo:eu-repo/semantics/openAccessoai:incliva.fundanetsuite.com:p46662026-06-07T16:35:31Z
dc.title.none.fl_str_mv Introduction: How evident is the evidence?
title Introduction: How evident is the evidence?
spellingShingle Introduction: How evident is the evidence?
Simon, Carlos
Randomized controlled trials
meta-analysis
reproductive medicine
evidence
research integrity
title_short Introduction: How evident is the evidence?
title_full Introduction: How evident is the evidence?
title_fullStr Introduction: How evident is the evidence?
title_full_unstemmed Introduction: How evident is the evidence?
title_sort Introduction: How evident is the evidence?
dc.creator.none.fl_str_mv Simon, Carlos
author Simon, Carlos
author_facet Simon, Carlos
author_role author
dc.subject.none.fl_str_mv Randomized controlled trials
meta-analysis
reproductive medicine
evidence
research integrity
topic Randomized controlled trials
meta-analysis
reproductive medicine
evidence
research integrity
description Randomized controlled trials (RCTs) and meta-analyses are the pinnacle of evidence-based medicine, enabling identification of the best available diagnostic, interventional, and therapeutic options. These tools help clinicians and policy makers to set clinical guidelines, but they also represent a double-edged sword: The meaningfulness of RCTs and meta-analyses relies on their quality, performance, and integrity. This Views and Reviews collection prepared by 18 renowned experts and coordinated by Ben Mol aims to inform and educate our readers about RCTs and meta-analyses in reproductive medicine. The collection begins with the basic features that guarantee the quality of a trial, including protocols, registrations and monitoring, study design/analysis, and reporting standards. Next are discussed the status of planning and coordination of RCTs in different global settings, current unmet needs, and how future studies can better meet these needs, as well as methodologic issues facing different types of RCTs. Finally, we provide insight into the issue of data fabrication and falsification, offering possible solutions to ensure the integrity of RCTs. The challenges and benefits of these crucial evidence-generating tools deserve our attention and education because the findings of RCTs and meta-analyses can directly affect the health of our patients, and when performance and integrity problems exist, the "magic" of these tools disappears-with harmful consequences. Copyright © 2020 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
publishDate 2020
dc.date.none.fl_str_mv 2020
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dc.identifier.none.fl_str_mv https://incliva.portalinvestigacion.com/publicaciones/4666
url https://incliva.portalinvestigacion.com/publicaciones/4666
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv ELSEVIER SCIENCE INC
publisher.none.fl_str_mv ELSEVIER SCIENCE INC
dc.source.none.fl_str_mv FERTILITY AND STERILITY
ISSN: 00150282
ISSNe: 15565653
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