Recent advances in the management of patients with non-muscle-invasive bladder cancer using a multidisciplinary approach

On the basis of the discussion of the current state of research on relevant topics of non-muscle-invasive bladder cancer (NMIBC) among a group of experts of the Spanish Oncology Gen-itourinary (SOGUG) Working Group, recommendations were proposed to overcome the challenges posed by the management of...

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Detalhes bibliográficos
Autores: Rubio-Briones, José, Algaba, Ferran|||0000-0002-0071-4164, Gallardo Díaz, Enrique|||0000-0002-1375-3488, Marcos-Rodríguez, José Antonio, Climent, Miguel Ángel|||0000-0001-7523-0212, Gomez-Caamaño, Antonio|||0000-0002-9773-4590, Garcia Vicente, Ana M., Maroto Rey, Pablo|||0000-0002-0030-0412, Rodríguez Antolín, Alfredo, Sanz, Julián, Vera González, Maria Almudena, González-del-Alba, Aránzazu|||0000-0001-6570-009X, Conde Moreno, Antonio José|||0000-0003-1024-0924, González-Haba, Eva, González-Peramato, Pilar, Linares Espinós, Estefania, López-Beltran, Antonio, Pelechano, Paula, Garrido, Marga, Gironés Sarrió, Regina, Zapatero, Almudena|||0000-0003-2930-2312, Arranz Alija, Jose Ángel
Formato: artículo
Fecha de publicación:2021
País:España
Recursos:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:270257
Acesso em linha:https://ddd.uab.cat/record/270257
https://dx.doi.org/urn:doi:10.3390/cancers13194762
Access Level:acceso abierto
Palavra-chave:Non-muscle-invasive bladder cancer
Microhematuria
Transurethral resection
Histological variants
Molecular subtypes
Immunotherapy
Descrição
Resumo:On the basis of the discussion of the current state of research on relevant topics of non-muscle-invasive bladder cancer (NMIBC) among a group of experts of the Spanish Oncology Gen-itourinary (SOGUG) Working Group, recommendations were proposed to overcome the challenges posed by the management of NMIBC in clinical practice. A unified definition of the term 'microhe-maturia' and the profile of the patient at risk are needed. Establishing a 'hematuria clinic' would contribute to a centralized and more efficient evaluation of patients with this clinical sign. Second or repeated transurethral resection (re-TUR) needs to be defined, including the time window after the first procedure within which re-TUR should be performed. Complete tumor resection is man-datory when feasible, with specification of the presence or absence of muscle. Budding should be used as a classification system, and stratification of T1 tumors especially in extensive and deep tu-mors, is advisable. The percentage of the high-grade component should always be reported, and, in multiple tumors, grades should be reported separately. Luminal and basal subtypes can be identi-fied because of possibly different clinical outcomes. Molecular subtypes and immunotherapy are incorporated in the management of muscle-invasive bladder cancer but data on NMIBC are still preliminary.

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