Multiple Genomic Landscapes of Recombination and Genomic Divergence in Wild Populations of House Mice-The Role of Chromosomal Fusions and Prdm9

Chromosomal fusions represent one of the most common types of chromosomal rearrangements found in nature. Yet, their role in shaping the genomic landscape of recombination and hence genome evolution remains largely unexplored. Here, we take advantage of wild mice populations with chromosomal fusions...

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Authors: Marin Garcia, Cristina|||0000-0002-5008-1078, Álvarez-González, Lucía|||0000-0001-8154-8614, Marin Gual, Laia|||0000-0003-1480-0976, Casillas Viladerrams, Sònia|||0000-0001-8191-0062, Picón, Judith, Yam, Keren, Garcias-Ramis, Maria Magdalena|||0000-0001-9725-5066, Vara González, Covadonga|||0000-0002-8264-9262, Ventura Queija, Jacinto|||0000-0001-7527-1532, Ruiz Herrera Moreno, Aurora|||0000-0003-3868-6151
Format: article
Publication Date:2024
Country:España
Institution:Universitat Autònoma de Barcelona
Repository:Dipòsit Digital de Documents de la UAB
Language:English
OAI Identifier:oai:ddd.uab.cat:300321
Online Access:https://ddd.uab.cat/record/300321
https://dx.doi.org/urn:doi:10.1093/molbev/msae063
Access Level:Open access
Keyword:Robertsonian fusions
Recombination
Crossovers
Prdm9
Genomic divergence
Mus musculus domesticus
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spelling Multiple Genomic Landscapes of Recombination and Genomic Divergence in Wild Populations of House Mice-The Role of Chromosomal Fusions and Prdm9Marin Garcia, Cristina|||0000-0002-5008-1078Álvarez-González, Lucía|||0000-0001-8154-8614Marin Gual, Laia|||0000-0003-1480-0976Casillas Viladerrams, Sònia|||0000-0001-8191-0062Picón, JudithYam, KerenGarcias-Ramis, Maria Magdalena|||0000-0001-9725-5066Vara González, Covadonga|||0000-0002-8264-9262Ventura Queija, Jacinto|||0000-0001-7527-1532Ruiz Herrera Moreno, Aurora|||0000-0003-3868-6151Robertsonian fusionsRecombinationCrossoversPrdm9Genomic divergenceMus musculus domesticusChromosomal fusions represent one of the most common types of chromosomal rearrangements found in nature. Yet, their role in shaping the genomic landscape of recombination and hence genome evolution remains largely unexplored. Here, we take advantage of wild mice populations with chromosomal fusions to evaluate the effect of this type of structural variant on genomic landscapes of recombination and divergence. To this aim, we combined cytological analysis of meiotic crossovers in primary spermatocytes with inferred analysis of recombination rates based on linkage disequilibrium using single nucleotide polymorphisms. Our results suggest the presence of a combined effect of Robertsonian fusions and Prdm9 allelic background, a gene involved in the formation of meiotic double strand breaks and postzygotic reproductive isolation, in reshaping genomic landscapes of recombination. We detected a chromosomal redistribution of meiotic recombination toward telomeric regions in metacentric chromosomes in mice with Robertsonian fusions when compared to nonfused mice. This repatterning was accompanied by increased levels of crossover interference and reduced levels of estimated recombination rates between populations, together with high levels of genomic divergence. Interestingly, we detected that Prdm9 allelic background was a major determinant of recombination rates at the population level, whereas Robertsonian fusions showed limited effects, restricted to centromeric regions of fused chromosomes. Altogether, our results provide new insights into the effect of Robertsonian fusions and Prdm9 background on meiotic recombination. 22024-01-0120242024-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/300321https://dx.doi.org/urn:doi:10.1093/molbev/msae063reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengAgencia Estatal de Investigación https://doi.org/10.13039/501100011033 CGL2017-83802-PAgencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2020-112557GB-I00Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2021/SGR-00122Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 BES-2015-072924Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 PRE-2018-083257Ministerio de Ciencia e Innovación https://doi.org/10.13039/501100004837 FPU18/03867open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3003212026-06-06T12:50:31Z
dc.title.none.fl_str_mv Multiple Genomic Landscapes of Recombination and Genomic Divergence in Wild Populations of House Mice-The Role of Chromosomal Fusions and Prdm9
title Multiple Genomic Landscapes of Recombination and Genomic Divergence in Wild Populations of House Mice-The Role of Chromosomal Fusions and Prdm9
spellingShingle Multiple Genomic Landscapes of Recombination and Genomic Divergence in Wild Populations of House Mice-The Role of Chromosomal Fusions and Prdm9
Marin Garcia, Cristina|||0000-0002-5008-1078
Robertsonian fusions
Recombination
Crossovers
Prdm9
Genomic divergence
Mus musculus domesticus
title_short Multiple Genomic Landscapes of Recombination and Genomic Divergence in Wild Populations of House Mice-The Role of Chromosomal Fusions and Prdm9
title_full Multiple Genomic Landscapes of Recombination and Genomic Divergence in Wild Populations of House Mice-The Role of Chromosomal Fusions and Prdm9
title_fullStr Multiple Genomic Landscapes of Recombination and Genomic Divergence in Wild Populations of House Mice-The Role of Chromosomal Fusions and Prdm9
title_full_unstemmed Multiple Genomic Landscapes of Recombination and Genomic Divergence in Wild Populations of House Mice-The Role of Chromosomal Fusions and Prdm9
title_sort Multiple Genomic Landscapes of Recombination and Genomic Divergence in Wild Populations of House Mice-The Role of Chromosomal Fusions and Prdm9
dc.creator.none.fl_str_mv Marin Garcia, Cristina|||0000-0002-5008-1078
Álvarez-González, Lucía|||0000-0001-8154-8614
Marin Gual, Laia|||0000-0003-1480-0976
Casillas Viladerrams, Sònia|||0000-0001-8191-0062
Picón, Judith
Yam, Keren
Garcias-Ramis, Maria Magdalena|||0000-0001-9725-5066
Vara González, Covadonga|||0000-0002-8264-9262
Ventura Queija, Jacinto|||0000-0001-7527-1532
Ruiz Herrera Moreno, Aurora|||0000-0003-3868-6151
author Marin Garcia, Cristina|||0000-0002-5008-1078
author_facet Marin Garcia, Cristina|||0000-0002-5008-1078
Álvarez-González, Lucía|||0000-0001-8154-8614
Marin Gual, Laia|||0000-0003-1480-0976
Casillas Viladerrams, Sònia|||0000-0001-8191-0062
Picón, Judith
Yam, Keren
Garcias-Ramis, Maria Magdalena|||0000-0001-9725-5066
Vara González, Covadonga|||0000-0002-8264-9262
Ventura Queija, Jacinto|||0000-0001-7527-1532
Ruiz Herrera Moreno, Aurora|||0000-0003-3868-6151
author_role author
author2 Álvarez-González, Lucía|||0000-0001-8154-8614
Marin Gual, Laia|||0000-0003-1480-0976
Casillas Viladerrams, Sònia|||0000-0001-8191-0062
Picón, Judith
Yam, Keren
Garcias-Ramis, Maria Magdalena|||0000-0001-9725-5066
Vara González, Covadonga|||0000-0002-8264-9262
Ventura Queija, Jacinto|||0000-0001-7527-1532
Ruiz Herrera Moreno, Aurora|||0000-0003-3868-6151
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Robertsonian fusions
Recombination
Crossovers
Prdm9
Genomic divergence
Mus musculus domesticus
topic Robertsonian fusions
Recombination
Crossovers
Prdm9
Genomic divergence
Mus musculus domesticus
description Chromosomal fusions represent one of the most common types of chromosomal rearrangements found in nature. Yet, their role in shaping the genomic landscape of recombination and hence genome evolution remains largely unexplored. Here, we take advantage of wild mice populations with chromosomal fusions to evaluate the effect of this type of structural variant on genomic landscapes of recombination and divergence. To this aim, we combined cytological analysis of meiotic crossovers in primary spermatocytes with inferred analysis of recombination rates based on linkage disequilibrium using single nucleotide polymorphisms. Our results suggest the presence of a combined effect of Robertsonian fusions and Prdm9 allelic background, a gene involved in the formation of meiotic double strand breaks and postzygotic reproductive isolation, in reshaping genomic landscapes of recombination. We detected a chromosomal redistribution of meiotic recombination toward telomeric regions in metacentric chromosomes in mice with Robertsonian fusions when compared to nonfused mice. This repatterning was accompanied by increased levels of crossover interference and reduced levels of estimated recombination rates between populations, together with high levels of genomic divergence. Interestingly, we detected that Prdm9 allelic background was a major determinant of recombination rates at the population level, whereas Robertsonian fusions showed limited effects, restricted to centromeric regions of fused chromosomes. Altogether, our results provide new insights into the effect of Robertsonian fusions and Prdm9 background on meiotic recombination.
publishDate 2024
dc.date.none.fl_str_mv 2
2024-01-01
2024
2024-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/300321
https://dx.doi.org/urn:doi:10.1093/molbev/msae063
url https://ddd.uab.cat/record/300321
https://dx.doi.org/urn:doi:10.1093/molbev/msae063
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 CGL2017-83802-P
Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2020-112557GB-I00
Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2021/SGR-00122
Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 BES-2015-072924
Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 PRE-2018-083257
Ministerio de Ciencia e Innovación https://doi.org/10.13039/501100004837 FPU18/03867
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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