Conservation of cis-Regulatory Syntax Underlying Deuterostome Gastrulation

© 2024 by the authors. Licensee MDPI, Basel, Switzerland.

Detalles Bibliográficos
Autores: Buono, Lorena, Annona, Giovanni, Magri, Marta Silvia, Negueruela, Santiago, Sepe, Rosa María, Caccavale, Filomena, Maeso, Ignacio, Arnone, M. I., D’Aniello, Salvatore
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/372331
Acceso en línea:http://hdl.handle.net/10261/372331
Access Level:acceso abierto
Palabra clave:Cis-regulatory element
Gene regulation
Transcription factor
Binding motif
Evo-Devo
ATAC-seq
id ES_d9a7c4cf3201216cd1c994895d1bec72
oai_identifier_str oai:digital.csic.es:10261/372331
network_acronym_str ES
network_name_str España
repository_id_str
spelling Conservation of cis-Regulatory Syntax Underlying Deuterostome GastrulationBuono, LorenaAnnona, GiovanniMagri, Marta SilviaNegueruela, SantiagoSepe, Rosa MaríaCaccavale, FilomenaMaeso, IgnacioArnone, M. I.D’Aniello, SalvatoreCis-regulatory elementGene regulationTranscription factorBinding motifEvo-DevoATAC-seq© 2024 by the authors. Licensee MDPI, Basel, Switzerland.Throughout embryonic development, the shaping of the functional and morphological characteristics of embryos is orchestrated by an intricate interaction between transcription factors and cis-regulatory elements. In this study, we conducted a comprehensive analysis of deuterostome cis-regulatory landscapes during gastrulation, focusing on four paradigmatic species: the echinoderm Strongylocentrotus purpuratus, the cephalochordate Branchiostoma lanceolatum, the urochordate Ciona intestinalis, and the vertebrate Danio rerio. Our approach involved comparative computational analysis of ATAC-seq datasets to explore the genome-wide blueprint of conserved transcription factor binding motifs underlying gastrulation. We identified a core set of conserved DNA binding motifs associated with 62 known transcription factors, indicating the remarkable conservation of the gastrulation regulatory landscape across deuterostomes. Our findings offer valuable insights into the evolutionary molecular dynamics of embryonic development, shedding light on conserved regulatory subprograms and providing a comprehensive perspective on the conservation and divergence of gene regulation underlying the gastrulation process.Peer reviewedMultidisciplinary Digital Publishing InstituteConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202420242024info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/372331reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésThe underlying dataset has been published as supplementary material of the article in the publisher platform at DOI https://doi.org/10.3390/cells13131121https://doi.org/10.3390/cells13131121Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3723312026-05-22T06:33:51Z
dc.title.none.fl_str_mv Conservation of cis-Regulatory Syntax Underlying Deuterostome Gastrulation
title Conservation of cis-Regulatory Syntax Underlying Deuterostome Gastrulation
spellingShingle Conservation of cis-Regulatory Syntax Underlying Deuterostome Gastrulation
Buono, Lorena
Cis-regulatory element
Gene regulation
Transcription factor
Binding motif
Evo-Devo
ATAC-seq
title_short Conservation of cis-Regulatory Syntax Underlying Deuterostome Gastrulation
title_full Conservation of cis-Regulatory Syntax Underlying Deuterostome Gastrulation
title_fullStr Conservation of cis-Regulatory Syntax Underlying Deuterostome Gastrulation
title_full_unstemmed Conservation of cis-Regulatory Syntax Underlying Deuterostome Gastrulation
title_sort Conservation of cis-Regulatory Syntax Underlying Deuterostome Gastrulation
dc.creator.none.fl_str_mv Buono, Lorena
Annona, Giovanni
Magri, Marta Silvia
Negueruela, Santiago
Sepe, Rosa María
Caccavale, Filomena
Maeso, Ignacio
Arnone, M. I.
D’Aniello, Salvatore
author Buono, Lorena
author_facet Buono, Lorena
Annona, Giovanni
Magri, Marta Silvia
Negueruela, Santiago
Sepe, Rosa María
Caccavale, Filomena
Maeso, Ignacio
Arnone, M. I.
D’Aniello, Salvatore
author_role author
author2 Annona, Giovanni
Magri, Marta Silvia
Negueruela, Santiago
Sepe, Rosa María
Caccavale, Filomena
Maeso, Ignacio
Arnone, M. I.
D’Aniello, Salvatore
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Cis-regulatory element
Gene regulation
Transcription factor
Binding motif
Evo-Devo
ATAC-seq
topic Cis-regulatory element
Gene regulation
Transcription factor
Binding motif
Evo-Devo
ATAC-seq
description © 2024 by the authors. Licensee MDPI, Basel, Switzerland.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/372331
url http://hdl.handle.net/10261/372331
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI https://doi.org/10.3390/cells13131121
https://doi.org/10.3390/cells13131121
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869421408365314048
score 15,812429

Similares en LA Referencia