Unravelling the Link between Polyphenol Intake and the Risk of Digestive System Cancer: An Umbrella Review Using Meta-Analyses and Systematic Reviews

Background Digestive system cancers (DSCs) constitute a significant number of cancer cases and are closely associated with modifiable risk factors.Objective This umbrella review synthesizes evidence from meta-analyses on the association between dietary polyphenol consumption and the risk of DSCs, ad...

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Autores: Amjadi, Arezo, Abbasi, Hamid, Tahavorgar, Atefeh, Esfahanian, Mohammadreza, Torkaman, Mahdie, Shahrokhi Sardoo, Adel, Erfanimanesh, Ali, Shamsi Goushki, Ali, Esmail Akbari, Mohammad, Alhouei, Barbod, Gholamalizadeh, Maryam, Doaei, Saeid
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2026
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:dnet:ubarcelona__::0b4249ed72d767bf2a00c5c8c6555485
Acceso en línea:https://hdl.handle.net/2445/228813
Access Level:acceso abierto
Palabra clave:Càncer gastrointestinal
Polifenols
Càncer d&apos
estómac
Gastrointestinal cancer
Polyphenols
Stomach cancer
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spelling Unravelling the Link between Polyphenol Intake and the Risk of Digestive System Cancer: An Umbrella Review Using Meta-Analyses and Systematic ReviewsAmjadi, ArezoAbbasi, HamidTahavorgar, AtefehEsfahanian, MohammadrezaTorkaman, MahdieShahrokhi Sardoo, AdelErfanimanesh, AliShamsi Goushki, AliEsmail Akbari, MohammadAlhouei, BarbodGholamalizadeh, MaryamDoaei, SaeidCàncer gastrointestinalPolifenolsCàncer d&aposestómacGastrointestinal cancerPolyphenolsStomach cancerBackground Digestive system cancers (DSCs) constitute a significant number of cancer cases and are closely associated with modifiable risk factors.Objective This umbrella review synthesizes evidence from meta-analyses on the association between dietary polyphenol consumption and the risk of DSCs, addressing limitations in the literature and identifying optimal polyphenol types and doses.Methods Following Preferred Reporting Items for Systematic and Meta-Analyses (PRISMA) guidelines, a comprehensive literature search was conducted across PubMed, Scopus and Web of Science until April 2025, using specific keywords related to polyphenols and DSCs. Eligible studies included meta-analyses that examined polyphenol intake and DSC risk. The quality was assessed via the AMSTAR 2 and GRADE framework. Statistical analyses were performed using RStudio, employing random-effects models based on the heterogeneity metrics.Results Data from six meta-analyses, encompassing 27 effect sizes, revealed a statistically significant 11% reduction in the risk of DSCs associated with polyphenol consumption (RR: 0.89; 95% CI: 0.85-0.93; I2: 63%). Subgroup analysis revealed significant risk reductions for specific polyphenol classes: flavonols (22%), quercetin (22%), anthocyanidins (16%), flavan-3-ols (12%) and isoflavones (9%). Publication bias was evident, but adjustments using the trim-and-fill method still indicated a 13% overall reduction in risk (RR: 0.87; 95% CI: 0.83-0.92; I2: 64%).Conclusions Our findings support the protective role of dietary polyphenols against DSCs, particularly flavonols and quercetin, suggesting that further investigations into the optimal intake levels and mechanisms of action are needed. These findings underscore the potential of dietary modification as a strategy for DSC prevention.Cambridge University Press (CUP)2026info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/228813Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1017/erm.2025.10027Expert Reviews in Molecular Medicine, 2026, vol. 28, e3https://doi.org/10.1017/erm.2025.10027cc-by (c) Amjadi, Arezo et al., 2026http://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessoai:dnet:ubarcelona__::0b4249ed72d767bf2a00c5c8c65554852026-05-27T06:46:51Z
dc.title.none.fl_str_mv Unravelling the Link between Polyphenol Intake and the Risk of Digestive System Cancer: An Umbrella Review Using Meta-Analyses and Systematic Reviews
title Unravelling the Link between Polyphenol Intake and the Risk of Digestive System Cancer: An Umbrella Review Using Meta-Analyses and Systematic Reviews
spellingShingle Unravelling the Link between Polyphenol Intake and the Risk of Digestive System Cancer: An Umbrella Review Using Meta-Analyses and Systematic Reviews
Amjadi, Arezo
Càncer gastrointestinal
Polifenols
Càncer d&apos
estómac
Gastrointestinal cancer
Polyphenols
Stomach cancer
title_short Unravelling the Link between Polyphenol Intake and the Risk of Digestive System Cancer: An Umbrella Review Using Meta-Analyses and Systematic Reviews
title_full Unravelling the Link between Polyphenol Intake and the Risk of Digestive System Cancer: An Umbrella Review Using Meta-Analyses and Systematic Reviews
title_fullStr Unravelling the Link between Polyphenol Intake and the Risk of Digestive System Cancer: An Umbrella Review Using Meta-Analyses and Systematic Reviews
title_full_unstemmed Unravelling the Link between Polyphenol Intake and the Risk of Digestive System Cancer: An Umbrella Review Using Meta-Analyses and Systematic Reviews
title_sort Unravelling the Link between Polyphenol Intake and the Risk of Digestive System Cancer: An Umbrella Review Using Meta-Analyses and Systematic Reviews
dc.creator.none.fl_str_mv Amjadi, Arezo
Abbasi, Hamid
Tahavorgar, Atefeh
Esfahanian, Mohammadreza
Torkaman, Mahdie
Shahrokhi Sardoo, Adel
Erfanimanesh, Ali
Shamsi Goushki, Ali
Esmail Akbari, Mohammad
Alhouei, Barbod
Gholamalizadeh, Maryam
Doaei, Saeid
author Amjadi, Arezo
author_facet Amjadi, Arezo
Abbasi, Hamid
Tahavorgar, Atefeh
Esfahanian, Mohammadreza
Torkaman, Mahdie
Shahrokhi Sardoo, Adel
Erfanimanesh, Ali
Shamsi Goushki, Ali
Esmail Akbari, Mohammad
Alhouei, Barbod
Gholamalizadeh, Maryam
Doaei, Saeid
author_role author
author2 Abbasi, Hamid
Tahavorgar, Atefeh
Esfahanian, Mohammadreza
Torkaman, Mahdie
Shahrokhi Sardoo, Adel
Erfanimanesh, Ali
Shamsi Goushki, Ali
Esmail Akbari, Mohammad
Alhouei, Barbod
Gholamalizadeh, Maryam
Doaei, Saeid
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Càncer gastrointestinal
Polifenols
Càncer d&apos
estómac
Gastrointestinal cancer
Polyphenols
Stomach cancer
topic Càncer gastrointestinal
Polifenols
Càncer d&apos
estómac
Gastrointestinal cancer
Polyphenols
Stomach cancer
description Background Digestive system cancers (DSCs) constitute a significant number of cancer cases and are closely associated with modifiable risk factors.Objective This umbrella review synthesizes evidence from meta-analyses on the association between dietary polyphenol consumption and the risk of DSCs, addressing limitations in the literature and identifying optimal polyphenol types and doses.Methods Following Preferred Reporting Items for Systematic and Meta-Analyses (PRISMA) guidelines, a comprehensive literature search was conducted across PubMed, Scopus and Web of Science until April 2025, using specific keywords related to polyphenols and DSCs. Eligible studies included meta-analyses that examined polyphenol intake and DSC risk. The quality was assessed via the AMSTAR 2 and GRADE framework. Statistical analyses were performed using RStudio, employing random-effects models based on the heterogeneity metrics.Results Data from six meta-analyses, encompassing 27 effect sizes, revealed a statistically significant 11% reduction in the risk of DSCs associated with polyphenol consumption (RR: 0.89; 95% CI: 0.85-0.93; I2: 63%). Subgroup analysis revealed significant risk reductions for specific polyphenol classes: flavonols (22%), quercetin (22%), anthocyanidins (16%), flavan-3-ols (12%) and isoflavones (9%). Publication bias was evident, but adjustments using the trim-and-fill method still indicated a 13% overall reduction in risk (RR: 0.87; 95% CI: 0.83-0.92; I2: 64%).Conclusions Our findings support the protective role of dietary polyphenols against DSCs, particularly flavonols and quercetin, suggesting that further investigations into the optimal intake levels and mechanisms of action are needed. These findings underscore the potential of dietary modification as a strategy for DSC prevention.
publishDate 2026
dc.date.none.fl_str_mv 2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/228813
url https://hdl.handle.net/2445/228813
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1017/erm.2025.10027
Expert Reviews in Molecular Medicine, 2026, vol. 28, e3
https://doi.org/10.1017/erm.2025.10027
dc.rights.none.fl_str_mv cc-by (c) Amjadi, Arezo et al., 2026
http://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Amjadi, Arezo et al., 2026
http://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Cambridge University Press (CUP)
publisher.none.fl_str_mv Cambridge University Press (CUP)
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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