Early measurement of interleukin-10 predicts the absence of CT scan lesions in mild traumatic brain injury

Traumatic brain injury is a common event where 70%-90% will be classified as mild TBI (mTBI). Among these, only 10% will have a brain lesion visible via CT scan. A triage biomarker would help clinicians to identify patients with mTBI who are at risk of developing a brain lesion and require a CT scan...

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Autores: Lagerstedt, Linnéa, Egea Guerrero, Juan José, Rodríguez Rodríguez, Ana, Bustamante, Alejandro|||0000-0003-4390-8900, Montaner, Joan|||0000-0003-4845-2279, El Rahal, Amir, Andereggen, Elisabeth, Rinaldi, Lara, Sarrafzadeh, Asita, Schaller, Karl, Sanchez, Jean-Charles|||0000-0002-8733-5932
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:204243
Acceso en línea:https://ddd.uab.cat/record/204243
https://dx.doi.org/urn:doi:10.1371/journal.pone.0193278
Access Level:acceso abierto
Palabra clave:Computed axial tomography
Biomarkers
Inflammation
Traumatic brain injury
Brain damage
Diagnostic medicine
Lesions
Serum proteins
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spelling Early measurement of interleukin-10 predicts the absence of CT scan lesions in mild traumatic brain injuryLagerstedt, LinnéaEgea Guerrero, Juan JoséRodríguez Rodríguez, AnaBustamante, Alejandro|||0000-0003-4390-8900Montaner, Joan|||0000-0003-4845-2279El Rahal, AmirAndereggen, ElisabethRinaldi, LaraSarrafzadeh, AsitaSchaller, KarlSanchez, Jean-Charles|||0000-0002-8733-5932Computed axial tomographyBiomarkersInflammationTraumatic brain injuryBrain damageDiagnostic medicineLesionsSerum proteinsTraumatic brain injury is a common event where 70%-90% will be classified as mild TBI (mTBI). Among these, only 10% will have a brain lesion visible via CT scan. A triage biomarker would help clinicians to identify patients with mTBI who are at risk of developing a brain lesion and require a CT scan. The brain cells damaged by the shearing, tearing and stretching of a TBI event set off inflammation cascades. These cause altered concentrations of a high number of both pro-inflammatory and anti-inflammatory proteins. This study aimed to discover a novel diagnostic biomarker of mTBI by investigating a broad panel of inflammation biomarkers and their capacity to correctly identify CT-positive and CT-negative patients. Patients enrolled in this study had been diagnosed with mTBI, had a GCS score of 15 and suffered from at least one clinical symptom. There were nine patients in the discovery group, 45 for verification, and 133 mTBI patients from two different European sites in the validation cohort. All patients gave blood samples, underwent a CT scan and were dichotomised into CT-positive and CT-negative groups for statistical analyses. The ability of each protein to classify patients was evaluated with sensitivity set at 100%. Three of the 92 inflammation proteins screened-MCP-1, MIP-1alpha and IL-10 -were further investigated in the verification group, and at 100% sensitivity their specificities reached 7%, 0% and 31%, respectively. IL-10 was validated on a larger cohort in comparison to the most studied mTBI diagnostic triage protein to date, S100B. Levels of both proteins were significantly higher in CT-positive than in CT-negative patients (p < 0.001). S100B's specificity at 100% sensitivity was 18% (95% CI 10.8-25.2), whereas IL-10 reached a specificity of 27% (95% CI 18.9-35.1). These results showed that IL-10 might be an interesting and clinically useful diagnostic tool, capable of differentiating between CT-positive and CT-negative mTBI patients. 22019-01-0120192019-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/204243https://dx.doi.org/urn:doi:10.1371/journal.pone.0193278reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2042432026-06-06T12:50:31Z
dc.title.none.fl_str_mv Early measurement of interleukin-10 predicts the absence of CT scan lesions in mild traumatic brain injury
title Early measurement of interleukin-10 predicts the absence of CT scan lesions in mild traumatic brain injury
spellingShingle Early measurement of interleukin-10 predicts the absence of CT scan lesions in mild traumatic brain injury
Lagerstedt, Linnéa
Computed axial tomography
Biomarkers
Inflammation
Traumatic brain injury
Brain damage
Diagnostic medicine
Lesions
Serum proteins
title_short Early measurement of interleukin-10 predicts the absence of CT scan lesions in mild traumatic brain injury
title_full Early measurement of interleukin-10 predicts the absence of CT scan lesions in mild traumatic brain injury
title_fullStr Early measurement of interleukin-10 predicts the absence of CT scan lesions in mild traumatic brain injury
title_full_unstemmed Early measurement of interleukin-10 predicts the absence of CT scan lesions in mild traumatic brain injury
title_sort Early measurement of interleukin-10 predicts the absence of CT scan lesions in mild traumatic brain injury
dc.creator.none.fl_str_mv Lagerstedt, Linnéa
Egea Guerrero, Juan José
Rodríguez Rodríguez, Ana
Bustamante, Alejandro|||0000-0003-4390-8900
Montaner, Joan|||0000-0003-4845-2279
El Rahal, Amir
Andereggen, Elisabeth
Rinaldi, Lara
Sarrafzadeh, Asita
Schaller, Karl
Sanchez, Jean-Charles|||0000-0002-8733-5932
author Lagerstedt, Linnéa
author_facet Lagerstedt, Linnéa
Egea Guerrero, Juan José
Rodríguez Rodríguez, Ana
Bustamante, Alejandro|||0000-0003-4390-8900
Montaner, Joan|||0000-0003-4845-2279
El Rahal, Amir
Andereggen, Elisabeth
Rinaldi, Lara
Sarrafzadeh, Asita
Schaller, Karl
Sanchez, Jean-Charles|||0000-0002-8733-5932
author_role author
author2 Egea Guerrero, Juan José
Rodríguez Rodríguez, Ana
Bustamante, Alejandro|||0000-0003-4390-8900
Montaner, Joan|||0000-0003-4845-2279
El Rahal, Amir
Andereggen, Elisabeth
Rinaldi, Lara
Sarrafzadeh, Asita
Schaller, Karl
Sanchez, Jean-Charles|||0000-0002-8733-5932
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Computed axial tomography
Biomarkers
Inflammation
Traumatic brain injury
Brain damage
Diagnostic medicine
Lesions
Serum proteins
topic Computed axial tomography
Biomarkers
Inflammation
Traumatic brain injury
Brain damage
Diagnostic medicine
Lesions
Serum proteins
description Traumatic brain injury is a common event where 70%-90% will be classified as mild TBI (mTBI). Among these, only 10% will have a brain lesion visible via CT scan. A triage biomarker would help clinicians to identify patients with mTBI who are at risk of developing a brain lesion and require a CT scan. The brain cells damaged by the shearing, tearing and stretching of a TBI event set off inflammation cascades. These cause altered concentrations of a high number of both pro-inflammatory and anti-inflammatory proteins. This study aimed to discover a novel diagnostic biomarker of mTBI by investigating a broad panel of inflammation biomarkers and their capacity to correctly identify CT-positive and CT-negative patients. Patients enrolled in this study had been diagnosed with mTBI, had a GCS score of 15 and suffered from at least one clinical symptom. There were nine patients in the discovery group, 45 for verification, and 133 mTBI patients from two different European sites in the validation cohort. All patients gave blood samples, underwent a CT scan and were dichotomised into CT-positive and CT-negative groups for statistical analyses. The ability of each protein to classify patients was evaluated with sensitivity set at 100%. Three of the 92 inflammation proteins screened-MCP-1, MIP-1alpha and IL-10 -were further investigated in the verification group, and at 100% sensitivity their specificities reached 7%, 0% and 31%, respectively. IL-10 was validated on a larger cohort in comparison to the most studied mTBI diagnostic triage protein to date, S100B. Levels of both proteins were significantly higher in CT-positive than in CT-negative patients (p < 0.001). S100B's specificity at 100% sensitivity was 18% (95% CI 10.8-25.2), whereas IL-10 reached a specificity of 27% (95% CI 18.9-35.1). These results showed that IL-10 might be an interesting and clinically useful diagnostic tool, capable of differentiating between CT-positive and CT-negative mTBI patients.
publishDate 2019
dc.date.none.fl_str_mv 2
2019-01-01
2019
2019-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/204243
https://dx.doi.org/urn:doi:10.1371/journal.pone.0193278
url https://ddd.uab.cat/record/204243
https://dx.doi.org/urn:doi:10.1371/journal.pone.0193278
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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