IL7RA rs10491434 polymorphism is related to spontaneous HIV infection control in naïve HIV-infected patients: A retrospective study.

Interleukin 7 receptor (IL7R) is vital in the adaptive immune response against human immunodeficiency viruses (HIV). We assessed IL7RA polymorphisms (SNPs) in antiretroviral therapy (ART)-naïve HIV patients for their association with spontaneous HIV infection control. We conducted a retrospective co...

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Detalles Bibliográficos
Autores: Sepulveda-Crespo, Daniel, Jimenez-Sousa, Maria Angeles, Fernandez-Rodriguez, Amanda, Muñoz-Fernández, María A, Jiménez, José L, Caraciolo, Begoña B, Reus Bañuls, Sergio, Vilchez, Helem, Mothe, Beatriz, Martinez, Isidoro, Benito, José M, Rallón, Norma, Resino, Salvador
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:dnet:repisalud__::a1223e0fac8e30170a22ec9defe5cfa2
Acceso en línea:https://hdl.handle.net/20.500.12105/27528
Access Level:acceso abierto
Palabra clave:HIV elite controllers
IL7 receptor
LTNPs
Single nucleotide polymorphisms
Disease Progression
HIV Infections
Humans
Infection Control
Interleukin-7 Receptor alpha Subunit
Polymorphism, Single Nucleotide
Retrospective Studies
Descripción
Sumario:Interleukin 7 receptor (IL7R) is vital in the adaptive immune response against human immunodeficiency viruses (HIV). We assessed IL7RA polymorphisms (SNPs) in antiretroviral therapy (ART)-naïve HIV patients for their association with spontaneous HIV infection control. We conducted a retrospective cohort study involving 667 ART-naïve patients categorized by HIV progression (ordinal variable): 150 rapid progressors, 334 moderate/typical progressors, 86 long-term nonprogressors elite controllers (LTNPs-EC), and 97 LTNPs-non-EC. We genotyped three IL7RA SNPs using Agena Bioscience's MassARRAY platform. The association between IL7RA SNPs and spontaneous HIV infection control was evaluated using ordinal logistic regression. Individuals carrying the rs10491434 G allele have a higher likelihood of spontaneous HIV infection control (adjusted odds ratio [aOR] = 1.33; p = 0.023). Moreover, the IL7RA GCT haplotype, consisting of three specific SNPs (rs6897932, rs987106, and rs10491434), demonstrated an association with the control of untreated HIV infection (aOR = 1.34; p = 0.050). Remarkably, the rs10491434 SNP and the IL7RA GCT haplotype exhibited similar aOR values, suggesting that rs10491434 may be primarily responsible for the observed effect of the haplotype. IL7RA rs10491434 G allele is associated with a higher likelihood of spontaneous HIV infection control, indicating its significant role in the pathogenesis of HIV, possibly influencing infection course and viral replication control.

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