Inference of functional relations in predicted protein networks with a machine learning approach

[Background] Molecular biology is currently facing the challenging task of functionally characterizing the proteome. The large number of possible protein-protein interactions and complexes, the variety of environmental conditions and cellular states in which these interactions can be reorganized, an...

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Detalles Bibliográficos
Autores: García-Jiménez, Beatriz, Juan, David, Ezkurdia, Iakes, Andrés-León, Eduardo, Valencia, Alfonso
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2010
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/412973
Acceso en línea:http://hdl.handle.net/10261/412973
https://api.elsevier.com/content/abstract/scopus_id/77956368930
Access Level:acceso abierto
Descripción
Sumario:[Background] Molecular biology is currently facing the challenging task of functionally characterizing the proteome. The large number of possible protein-protein interactions and complexes, the variety of environmental conditions and cellular states in which these interactions can be reorganized, and the multiple ways in which a protein can influence the function of others, requires the development of experimental and computational approaches to analyze and predict functional associations between proteins as part of their activity in the interactome