A propensity-score-matched analysis of laparoscopic vs open surgery for rectal cancer in a population-based study / P. Manchon-Walsh, L. Aliste, S. Biondo, E. Espin, M. Pera, E. Targarona, N. Pallarès, R. Vernet, J. A. Espinàs, A. Guarga, J. M. Borràs
Abstract Aim The oncological risk/benefit trade‐off for laparoscopy in rectal cancer is controversial. Our aim was to compare laparoscopic vs open surgery for resection of rectal cancer, using unselected data from the public healthcare system of Catalonia (Spain). Methods This was a multicentre retr...
| Autores: | , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2018 |
| País: | España |
| Institución: | Universitat de Girona (UdG) |
| Repositorio: | DDEUIT. Dipòsit Digital de l'Escola Universitària d'Infermeria i Teràpia Ocupacional de Terrassa |
| OAI Identifier: | DIPOSIT-EUIT:56305 |
| Acceso en línea: | https://biblioteca.euit.fdsll.cat/cgi-bin/koha/opac-detail.pl?biblionumber=56305 |
| Access Level: | acceso abierto |
| Palabra clave: | Càncer de recte Laparoscòpia Cirurgia Professors Càncer colorectal Colorectal cancer Laparoscopy Surgery Statistics Spain Catalonia |
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| dc.title.none.fl_str_mv |
A propensity-score-matched analysis of laparoscopic vs open surgery for rectal cancer in a population-based study / P. Manchon-Walsh, L. Aliste, S. Biondo, E. Espin, M. Pera, E. Targarona, N. Pallarès, R. Vernet, J. A. Espinàs, A. Guarga, J. M. Borràs |
| title |
A propensity-score-matched analysis of laparoscopic vs open surgery for rectal cancer in a population-based study / P. Manchon-Walsh, L. Aliste, S. Biondo, E. Espin, M. Pera, E. Targarona, N. Pallarès, R. Vernet, J. A. Espinàs, A. Guarga, J. M. Borràs |
| spellingShingle |
A propensity-score-matched analysis of laparoscopic vs open surgery for rectal cancer in a population-based study / P. Manchon-Walsh, L. Aliste, S. Biondo, E. Espin, M. Pera, E. Targarona, N. Pallarès, R. Vernet, J. A. Espinàs, A. Guarga, J. M. Borràs Manchon-Walsh, Paula, Càncer de recte Laparoscòpia Cirurgia Professors Càncer colorectal Colorectal cancer Laparoscopy Surgery Statistics Spain Catalonia |
| title_short |
A propensity-score-matched analysis of laparoscopic vs open surgery for rectal cancer in a population-based study / P. Manchon-Walsh, L. Aliste, S. Biondo, E. Espin, M. Pera, E. Targarona, N. Pallarès, R. Vernet, J. A. Espinàs, A. Guarga, J. M. Borràs |
| title_full |
A propensity-score-matched analysis of laparoscopic vs open surgery for rectal cancer in a population-based study / P. Manchon-Walsh, L. Aliste, S. Biondo, E. Espin, M. Pera, E. Targarona, N. Pallarès, R. Vernet, J. A. Espinàs, A. Guarga, J. M. Borràs |
| title_fullStr |
A propensity-score-matched analysis of laparoscopic vs open surgery for rectal cancer in a population-based study / P. Manchon-Walsh, L. Aliste, S. Biondo, E. Espin, M. Pera, E. Targarona, N. Pallarès, R. Vernet, J. A. Espinàs, A. Guarga, J. M. Borràs |
| title_full_unstemmed |
A propensity-score-matched analysis of laparoscopic vs open surgery for rectal cancer in a population-based study / P. Manchon-Walsh, L. Aliste, S. Biondo, E. Espin, M. Pera, E. Targarona, N. Pallarès, R. Vernet, J. A. Espinàs, A. Guarga, J. M. Borràs |
| title_sort |
A propensity-score-matched analysis of laparoscopic vs open surgery for rectal cancer in a population-based study / P. Manchon-Walsh, L. Aliste, S. Biondo, E. Espin, M. Pera, E. Targarona, N. Pallarès, R. Vernet, J. A. Espinàs, A. Guarga, J. M. Borràs |
| dc.creator.none.fl_str_mv |
Manchon-Walsh, Paula, 0000-0001-9089-0577 Aliste Sánchez, Luisa 0000-0003-0683-1713 Biondo, Sebastián Espin, Eloy, 0000-0002-9139-4548 Pera Román, Miguel 0000-0001-7764-6481 Targarona, Eduardo M. Pallarès, Natàlia, 0000-0002-1462-379X Vernet Bellet, Raül, 0000-0002-1964-6974 Espinàs Piñol, Josep Alfons 0000-0002-4027-7114 Guarga, Alex 0009-0009-8817-3152 Borràs Andrés, Josep Maria, 0000-0001-7330-6308 EUIT Institut d'Investigació Biomèdica de Bellvitge |
| author |
Manchon-Walsh, Paula, |
| author_facet |
Manchon-Walsh, Paula, 0000-0001-9089-0577 Aliste Sánchez, Luisa 0000-0003-0683-1713 Biondo, Sebastián Espin, Eloy, 0000-0002-9139-4548 Pera Román, Miguel 0000-0001-7764-6481 Targarona, Eduardo M. Pallarès, Natàlia, 0000-0002-1462-379X Vernet Bellet, Raül, 0000-0002-1964-6974 Espinàs Piñol, Josep Alfons 0000-0002-4027-7114 Guarga, Alex 0009-0009-8817-3152 Borràs Andrés, Josep Maria, 0000-0001-7330-6308 EUIT Institut d'Investigació Biomèdica de Bellvitge |
| author_role |
author |
| author2 |
0000-0001-9089-0577 Aliste Sánchez, Luisa 0000-0003-0683-1713 Biondo, Sebastián Espin, Eloy, 0000-0002-9139-4548 Pera Román, Miguel 0000-0001-7764-6481 Targarona, Eduardo M. Pallarès, Natàlia, 0000-0002-1462-379X Vernet Bellet, Raül, 0000-0002-1964-6974 Espinàs Piñol, Josep Alfons 0000-0002-4027-7114 Guarga, Alex 0009-0009-8817-3152 Borràs Andrés, Josep Maria, 0000-0001-7330-6308 EUIT Institut d'Investigació Biomèdica de Bellvitge |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Càncer de recte Laparoscòpia Cirurgia Professors Càncer colorectal Colorectal cancer Laparoscopy Surgery Statistics Spain Catalonia |
| topic |
Càncer de recte Laparoscòpia Cirurgia Professors Càncer colorectal Colorectal cancer Laparoscopy Surgery Statistics Spain Catalonia |
| description |
Abstract Aim The oncological risk/benefit trade‐off for laparoscopy in rectal cancer is controversial. Our aim was to compare laparoscopic vs open surgery for resection of rectal cancer, using unselected data from the public healthcare system of Catalonia (Spain). Methods This was a multicentre retrospective cohort study of all patients who had surgery with curative intent for primary rectal cancer at Catalonian public hospitals from 2011 to 2012. We obtained follow‐up data for up to 5 years. To minimize the differences between the two groups, we performed propensity score matching on baseline patient characteristics. We used multivariate Cox proportional hazards regression analyses to assess locoregional relapse at 2 years and death at 2 and 5 years. Results Of 1513 patients with Stage I-III rectal cancer, 933 (61.7%) had laparoscopy (conversion rate 13.2%). After applying our propensity score matching strategy (2:1), 842 laparoscopy patients were matched to 517 open surgery patients. Multivariate Cox analysis of death at 2 years [hazard ratio (HR) 0.65, 95% CI 0.48, 0.87; P = 0.004] and 5 years (HR 0.61, 95% CI 0.5, 0.75; P < 0.001) and of local relapse at 2 years (HR 0.44, 95% CI 0.27, 0.72; P = 0.001) showed laparoscopy to be an independent protective factor compared with open surgery. Conclusions Laparoscopy results in lower locoregional relapse and long‐term mortality in rectal cancer in unselected patients with all‐risk groups included. Studies using long‐term follow‐up of cohorts and unselected data can provide information on clinically relevant outcomes to supplement randomized controlled trials. |
| publishDate |
2018 |
| dc.date.none.fl_str_mv |
2018 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/postprintVersion info:eu-repo/semantics/postprintVersion |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://biblioteca.euit.fdsll.cat/cgi-bin/koha/opac-detail.pl?biblionumber=56305 |
| url |
https://biblioteca.euit.fdsll.cat/cgi-bin/koha/opac-detail.pl?biblionumber=56305 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
This study has been partially funded by the Agència de Gestió d'Ajuts Universitaris i de Recerca, (AGAUR, 2017SGR735). Colorectal Disease 2019;21(4):441-450 |
| dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess Tots els drets reservats https://rightsstatements.org/page/InC/1.0/?language=es |
| eu_rights_str_mv |
openAccess |
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Tots els drets reservats https://rightsstatements.org/page/InC/1.0/?language=es |
| dc.format.none.fl_str_mv |
application/pdf application/pdf |
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reponame:DDEUIT. Dipòsit Digital de l'Escola Universitària d'Infermeria i Teràpia Ocupacional de Terrassa instname:Universitat de Girona (UdG) |
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Universitat de Girona (UdG) |
| reponame_str |
DDEUIT. Dipòsit Digital de l'Escola Universitària d'Infermeria i Teràpia Ocupacional de Terrassa |
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DDEUIT. Dipòsit Digital de l'Escola Universitària d'Infermeria i Teràpia Ocupacional de Terrassa |
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A propensity-score-matched analysis of laparoscopic vs open surgery for rectal cancer in a population-based study / P. Manchon-Walsh, L. Aliste, S. Biondo, E. Espin, M. Pera, E. Targarona, N. Pallarès, R. Vernet, J. A. Espinàs, A. Guarga, J. M. BorràsManchon-Walsh, Paula,0000-0001-9089-0577Aliste Sánchez, Luisa0000-0003-0683-1713Biondo, Sebastián Espin, Eloy,0000-0002-9139-4548Pera Román, Miguel0000-0001-7764-6481Targarona, Eduardo M.Pallarès, Natàlia,0000-0002-1462-379XVernet Bellet, Raül,0000-0002-1964-6974Espinàs Piñol, Josep Alfons0000-0002-4027-7114Guarga, Alex0009-0009-8817-3152Borràs Andrés, Josep Maria,0000-0001-7330-6308EUITInstitut d'Investigació Biomèdica de BellvitgeCàncer de recteLaparoscòpiaCirurgiaProfessorsCàncer colorectalColorectal cancerLaparoscopySurgeryStatisticsSpainCataloniaAbstract Aim The oncological risk/benefit trade‐off for laparoscopy in rectal cancer is controversial. Our aim was to compare laparoscopic vs open surgery for resection of rectal cancer, using unselected data from the public healthcare system of Catalonia (Spain). Methods This was a multicentre retrospective cohort study of all patients who had surgery with curative intent for primary rectal cancer at Catalonian public hospitals from 2011 to 2012. We obtained follow‐up data for up to 5 years. To minimize the differences between the two groups, we performed propensity score matching on baseline patient characteristics. We used multivariate Cox proportional hazards regression analyses to assess locoregional relapse at 2 years and death at 2 and 5 years. Results Of 1513 patients with Stage I-III rectal cancer, 933 (61.7%) had laparoscopy (conversion rate 13.2%). After applying our propensity score matching strategy (2:1), 842 laparoscopy patients were matched to 517 open surgery patients. Multivariate Cox analysis of death at 2 years [hazard ratio (HR) 0.65, 95% CI 0.48, 0.87; P = 0.004] and 5 years (HR 0.61, 95% CI 0.5, 0.75; P < 0.001) and of local relapse at 2 years (HR 0.44, 95% CI 0.27, 0.72; P = 0.001) showed laparoscopy to be an independent protective factor compared with open surgery. Conclusions Laparoscopy results in lower locoregional relapse and long‐term mortality in rectal cancer in unselected patients with all‐risk groups included. Studies using long‐term follow‐up of cohorts and unselected data can provide information on clinically relevant outcomes to supplement randomized controlled trials.Manchon-Walsh P, Aliste L, Biondo S, Espin E, Pera M, Targarona E, Pallarès N, Vernet R, Espinàs JA, Guarga A, Borràs JM. A propensity-score-matched analysis of laparoscopic vs open surgery for rectal cancer in a population-based study. Colorectal Dis. 2019 Apr;21(4):441-450. doi: 10.1111/codi.14545. Epub 2019 Jan 17. PMID: 30585686.This study has been partially funded by the Agència de Gestió d'Ajuts Universitaris i de Recerca, (AGAUR, 2017SGR735).MÈTRIQUES Journal Impact Factor (Journal Citation Reports) • Any: 2017 (És l'últim any del que es disposen dades) • Factor d'impacte: 2.778 • Categoria: GASTROENTEROLOGY & HEPATOLOGY • Posició de la revista: 49/80 • Quartil: Q3 • Categoria: SURGERY • Posició de la revista: 49/200 • Quartil: Q1 CiteScore (Scopus Journal Metrics) • Any: 2017 • Factor d'impacte: 1.86 • Categoria: Medicine - Gastroenterology • Posició de la revista: #58/128 • Percentil: 54th Almetric https://wiley.altmetric.com/details/53185782 Bases de dades on s'indexa Science Citation Index Expanded, Scopus, Academic Search Premier, Agricultural & Environmental Science Database, EMBASE, MEDLINE Descripció del recurs: 21 gener 2019DDEUIT2018info:eu-repo/semantics/articleinfo:eu-repo/semantics/postprintVersioninfo:eu-repo/semantics/postprintVersionapplication/pdfapplication/pdfhttps://biblioteca.euit.fdsll.cat/cgi-bin/koha/opac-detail.pl?biblionumber=56305reponame:DDEUIT. Dipòsit Digital de l'Escola Universitària d'Infermeria i Teràpia Ocupacional de Terrassainstname:Universitat de Girona (UdG)InglésThis study has been partially funded by the Agència de Gestió d'Ajuts Universitaris i de Recerca, (AGAUR, 2017SGR735).Colorectal Disease 2019;21(4):441-450info:eu-repo/semantics/openAccessTots els drets reservatshttps://rightsstatements.org/page/InC/1.0/?language=esDIPOSIT-EUIT:563052026-06-21T12:53:37Z |
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15,300719 |