Immunomodulatory Function of Polyvinylpyrrolidone (PVP)-Functionalized Gold Nanoparticles in Vibrio-Stimulated Sea Urchin Immune Cells
Cèl·lules immunitàries d'eriçó de mar infectades; Nanointeracció; Quiescència i activació immune
| Autores: | , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Departament de Salut de la Generalitat de Catalunya (DS) |
| Repositorio: | Scientia. Dipòsit d'Informació Digital del Departament de Salut |
| OAI Identifier: | oai:scientiasalut.gencat.cat:11351/7440 |
| Acceso en línea: | https://hdl.handle.net/11351/7440 |
| Access Level: | acceso abierto |
| Palabra clave: | Immunitat natural Malalties bacterianes gramnegatives Nanopartícules TECHNOLOGY, INDUSTRY, AND AGRICULTURE::Technology, Industry, and Agriculture::Manufactured Materials::Nanostructures::Nanoparticles::Metal Nanoparticles DISEASES::Bacterial Infections and Mycoses::Bacterial Infections::Gram-Negative Bacterial Infections::Vibrio Infections PHENOMENA AND PROCESSES::Immune System Phenomena::Immunity::Immunity, Innate TECNOLOGÍA, INDUSTRIA Y AGRICULTURA::tecnología, industria y agricultura::productos manufacturados::nanoestructuras::nanopartículas::nanopartículas metálicas ENFERMEDADES::infecciones bacterianas y micosis::infecciones bacterianas::infecciones por bacterias gramnegativas::vibriosis FENÓMENOS Y PROCESOS::fenómenos del sistema inmunitario::inmunidad::inmunidad innata |
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Immunomodulatory Function of Polyvinylpyrrolidone (PVP)-Functionalized Gold Nanoparticles in Vibrio-Stimulated Sea Urchin Immune CellsAlijagic, AndiBonura, AngelaBarbero, FrancescoFranco Puntes, VictorGervasi, FrancescoPinsino, AnnalisaImmunitat naturalMalalties bacterianes gramnegativesNanopartículesTECHNOLOGY, INDUSTRY, AND AGRICULTURE::Technology, Industry, and Agriculture::Manufactured Materials::Nanostructures::Nanoparticles::Metal NanoparticlesDISEASES::Bacterial Infections and Mycoses::Bacterial Infections::Gram-Negative Bacterial Infections::Vibrio InfectionsPHENOMENA AND PROCESSES::Immune System Phenomena::Immunity::Immunity, InnateTECNOLOGÍA, INDUSTRIA Y AGRICULTURA::tecnología, industria y agricultura::productos manufacturados::nanoestructuras::nanopartículas::nanopartículas metálicasENFERMEDADES::infecciones bacterianas y micosis::infecciones bacterianas::infecciones por bacterias gramnegativas::vibriosisFENÓMENOS Y PROCESOS::fenómenos del sistema inmunitario::inmunidad::inmunidad innataCèl·lules immunitàries d'eriçó de mar infectades; Nanointeracció; Quiescència i activació immuneCélulas inmunes de erizo de mar infectadas; Nanointeracción; Quiescencia y activación inmuneInfected sea urchin immune cells; Inanointeraction; Quiescence and immune activationWe investigated the role of the gold nanoparticles functionalized with polyvinylpyrrolidone (PVP–AuNPs) on the innate immune response against an acute infection caused by Vibrio anguillarum in an in vitro immunological nonmammalian next-generation model, the sea urchin Paracentrotus lividus. To profile the immunomodulatory function of PVP–AuNPs (0.1 μg mL−1) in sea urchin immune cells stimulated by Vibrio (10 μg mL−1) for 3 h, we focused on the baseline immunological state of the donor, and we analysed the topography, cellular metabolism, and expression of human cell surface antigens of the exposed cells, as well as the signalling leading the interaction between PVP–AuNPs and the Vibrio-stimulated cells. PVP–AuNPs are not able to silence the inflammatory signalling (TLR4/p38MAPK/NF-κB signalling) that involves the whole population of P. lividus immune cells exposed to Vibrio. However, our findings emphasise the ability of PVP–AuNPs to stimulate a subset of rare cells (defined here as Group 3) that express CD45 and CD14 antigens on their surface, which are known to be involved in immune cell maturation and macrophage activation in humans. Our evidence on how PVP–AuNPs may stimulate sea urchin immune cells represents an important starting point for planning new research work on the topic.This project has received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement (No. 671881).MDPIInstitut Català de la Salut[Alijagic A, Bonura A, Pinsino A] Consiglio Nazionale delle Ricerche, Istituto per la Ricerca e l’Innovazione Biomedica (IRIB), 90146 Palermo, Italy. [Barbero F] Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC and BIST, Campus UAB, Bellaterra, 08193 Barcelona, Spain. [Puntes VF] Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC and BIST, Campus UAB, Bellaterra, 08193 Barcelona, Spain. Institució Catalana de Recerca i Estudis Avançats (ICREA), 08010 Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. [Gervasi F] Specialistic Oncology Laboratory Unit, ARNAS Hospitals Civico Di Cristina e Benfratelli, 90127 Palermo, ItalyVall d'Hebron Barcelona Hospital Campus202220222021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11351/7440Scientiareponame:Scientia. Dipòsit d'Informació Digital del Departament de Salutinstname:Departament de Salut de la Generalitat de Catalunya (DS)InglésNanomaterials;11(10)https://doi.org/10.3390/nano11102646info:eu-repo/grantAgreement/EC/H2020/671881Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:scientiasalut.gencat.cat:11351/74402026-06-12T09:38:37Z |
| dc.title.none.fl_str_mv |
Immunomodulatory Function of Polyvinylpyrrolidone (PVP)-Functionalized Gold Nanoparticles in Vibrio-Stimulated Sea Urchin Immune Cells |
| title |
Immunomodulatory Function of Polyvinylpyrrolidone (PVP)-Functionalized Gold Nanoparticles in Vibrio-Stimulated Sea Urchin Immune Cells |
| spellingShingle |
Immunomodulatory Function of Polyvinylpyrrolidone (PVP)-Functionalized Gold Nanoparticles in Vibrio-Stimulated Sea Urchin Immune Cells Alijagic, Andi Immunitat natural Malalties bacterianes gramnegatives Nanopartícules TECHNOLOGY, INDUSTRY, AND AGRICULTURE::Technology, Industry, and Agriculture::Manufactured Materials::Nanostructures::Nanoparticles::Metal Nanoparticles DISEASES::Bacterial Infections and Mycoses::Bacterial Infections::Gram-Negative Bacterial Infections::Vibrio Infections PHENOMENA AND PROCESSES::Immune System Phenomena::Immunity::Immunity, Innate TECNOLOGÍA, INDUSTRIA Y AGRICULTURA::tecnología, industria y agricultura::productos manufacturados::nanoestructuras::nanopartículas::nanopartículas metálicas ENFERMEDADES::infecciones bacterianas y micosis::infecciones bacterianas::infecciones por bacterias gramnegativas::vibriosis FENÓMENOS Y PROCESOS::fenómenos del sistema inmunitario::inmunidad::inmunidad innata |
| title_short |
Immunomodulatory Function of Polyvinylpyrrolidone (PVP)-Functionalized Gold Nanoparticles in Vibrio-Stimulated Sea Urchin Immune Cells |
| title_full |
Immunomodulatory Function of Polyvinylpyrrolidone (PVP)-Functionalized Gold Nanoparticles in Vibrio-Stimulated Sea Urchin Immune Cells |
| title_fullStr |
Immunomodulatory Function of Polyvinylpyrrolidone (PVP)-Functionalized Gold Nanoparticles in Vibrio-Stimulated Sea Urchin Immune Cells |
| title_full_unstemmed |
Immunomodulatory Function of Polyvinylpyrrolidone (PVP)-Functionalized Gold Nanoparticles in Vibrio-Stimulated Sea Urchin Immune Cells |
| title_sort |
Immunomodulatory Function of Polyvinylpyrrolidone (PVP)-Functionalized Gold Nanoparticles in Vibrio-Stimulated Sea Urchin Immune Cells |
| dc.creator.none.fl_str_mv |
Alijagic, Andi Bonura, Angela Barbero, Francesco Franco Puntes, Victor Gervasi, Francesco Pinsino, Annalisa |
| author |
Alijagic, Andi |
| author_facet |
Alijagic, Andi Bonura, Angela Barbero, Francesco Franco Puntes, Victor Gervasi, Francesco Pinsino, Annalisa |
| author_role |
author |
| author2 |
Bonura, Angela Barbero, Francesco Franco Puntes, Victor Gervasi, Francesco Pinsino, Annalisa |
| author2_role |
author author author author author |
| dc.contributor.none.fl_str_mv |
Institut Català de la Salut [Alijagic A, Bonura A, Pinsino A] Consiglio Nazionale delle Ricerche, Istituto per la Ricerca e l’Innovazione Biomedica (IRIB), 90146 Palermo, Italy. [Barbero F] Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC and BIST, Campus UAB, Bellaterra, 08193 Barcelona, Spain. [Puntes VF] Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC and BIST, Campus UAB, Bellaterra, 08193 Barcelona, Spain. Institució Catalana de Recerca i Estudis Avançats (ICREA), 08010 Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. [Gervasi F] Specialistic Oncology Laboratory Unit, ARNAS Hospitals Civico Di Cristina e Benfratelli, 90127 Palermo, Italy Vall d'Hebron Barcelona Hospital Campus |
| dc.subject.none.fl_str_mv |
Immunitat natural Malalties bacterianes gramnegatives Nanopartícules TECHNOLOGY, INDUSTRY, AND AGRICULTURE::Technology, Industry, and Agriculture::Manufactured Materials::Nanostructures::Nanoparticles::Metal Nanoparticles DISEASES::Bacterial Infections and Mycoses::Bacterial Infections::Gram-Negative Bacterial Infections::Vibrio Infections PHENOMENA AND PROCESSES::Immune System Phenomena::Immunity::Immunity, Innate TECNOLOGÍA, INDUSTRIA Y AGRICULTURA::tecnología, industria y agricultura::productos manufacturados::nanoestructuras::nanopartículas::nanopartículas metálicas ENFERMEDADES::infecciones bacterianas y micosis::infecciones bacterianas::infecciones por bacterias gramnegativas::vibriosis FENÓMENOS Y PROCESOS::fenómenos del sistema inmunitario::inmunidad::inmunidad innata |
| topic |
Immunitat natural Malalties bacterianes gramnegatives Nanopartícules TECHNOLOGY, INDUSTRY, AND AGRICULTURE::Technology, Industry, and Agriculture::Manufactured Materials::Nanostructures::Nanoparticles::Metal Nanoparticles DISEASES::Bacterial Infections and Mycoses::Bacterial Infections::Gram-Negative Bacterial Infections::Vibrio Infections PHENOMENA AND PROCESSES::Immune System Phenomena::Immunity::Immunity, Innate TECNOLOGÍA, INDUSTRIA Y AGRICULTURA::tecnología, industria y agricultura::productos manufacturados::nanoestructuras::nanopartículas::nanopartículas metálicas ENFERMEDADES::infecciones bacterianas y micosis::infecciones bacterianas::infecciones por bacterias gramnegativas::vibriosis FENÓMENOS Y PROCESOS::fenómenos del sistema inmunitario::inmunidad::inmunidad innata |
| description |
Cèl·lules immunitàries d'eriçó de mar infectades; Nanointeracció; Quiescència i activació immune |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021 2022 2022 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/11351/7440 |
| url |
https://hdl.handle.net/11351/7440 |
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Inglés |
| language_invalid_str_mv |
Inglés |
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Nanomaterials;11(10) https://doi.org/10.3390/nano11102646 info:eu-repo/grantAgreement/EC/H2020/671881 |
| dc.rights.none.fl_str_mv |
Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
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Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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application/pdf application/pdf |
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MDPI |
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MDPI |
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Scientia reponame:Scientia. Dipòsit d'Informació Digital del Departament de Salut instname:Departament de Salut de la Generalitat de Catalunya (DS) |
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Departament de Salut de la Generalitat de Catalunya (DS) |
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Scientia. Dipòsit d'Informació Digital del Departament de Salut |
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Scientia. Dipòsit d'Informació Digital del Departament de Salut |
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1869421385534668800 |
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15,811543 |