Chitosan-Based Mucoadhesive Vaginal Tablets for Controlled Release of the Anti-HIV Drug Tenofovir

Vaginal microbicides have the potential to give women at high risk of contracting HIV the option of self-protection by preventing the sexual transmission of the virus. In this paper, mucoadhesive vaginal tablets based on chitosan, alone and in combination with pectin and locust bean gum, were develo...

Descripción completa

Detalles Bibliográficos
Autores: Cazorla Luna, Raúl, Notario Pérez, Fernando, Martín Illana, Araceli, Ruiz Caro, Roberto, Tamayo, Aitana, Rubio, Juan, Veiga Ochoa, María Dolores
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/12758
Acceso en línea:https://hdl.handle.net/20.500.14352/12758
Access Level:acceso abierto
Palabra clave:615.4
Vaginal preexposure prophylaxis of HIV
Tenofovir controlled release
Mucoadhesive vaginal tablets
Natural polymers combination
Chitosan
Pectin
Locust bean gum
Tecnología farmaceútica
id ES_d95eeba0d2c2bfa0f4775b46fb9ba6ce
oai_identifier_str oai:docta.ucm.es:20.500.14352/12758
network_acronym_str ES
network_name_str España
repository_id_str
spelling Chitosan-Based Mucoadhesive Vaginal Tablets for Controlled Release of the Anti-HIV Drug TenofovirCazorla Luna, RaúlNotario Pérez, FernandoMartín Illana, AraceliRuiz Caro, RobertoTamayo, AitanaRubio, JuanVeiga Ochoa, María Dolores615.4Vaginal preexposure prophylaxis of HIVTenofovir controlled releaseMucoadhesive vaginal tabletsNatural polymers combinationChitosanPectinLocust bean gumTecnología farmaceúticaVaginal microbicides have the potential to give women at high risk of contracting HIV the option of self-protection by preventing the sexual transmission of the virus. In this paper, mucoadhesive vaginal tablets based on chitosan, alone and in combination with pectin and locust bean gum, were developed for the sustained release of tenofovir (an antiretroviral drug). The formulations were placed in simulant vaginal fluid (SVF) to swell, and Hg porosity and SEM microscopy were used for the microstructural characterization of the swelling witnesses. The results show that the association of pectin and chitosan generated polyelectrolyte complexes and produced a robust system able to maintain its structure during the swelling process, when small pores are formed. Drug reléase and bovine vaginal mucoadhesion studies were performed in SVF showing that tenofovir-controlled dissolution profiles and adhesion to the mucosa were conditioned by the swelling processes of the polymer/s in each formulation. Tablets based on chitosan/pectin have the most homogeneous tenofovir dissolution profiles and last up to 96 h, remaining attached to the vaginal mucosa for the same period. These formulations can therefore be considered a good option for the self-protection of women from the sexual transmission of HIV.MDPIUniversidad Complutense de Madrid20192019-01-0120192019-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/12758reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 3.0 Españahttps://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/127582026-06-02T12:44:21Z
dc.title.none.fl_str_mv Chitosan-Based Mucoadhesive Vaginal Tablets for Controlled Release of the Anti-HIV Drug Tenofovir
title Chitosan-Based Mucoadhesive Vaginal Tablets for Controlled Release of the Anti-HIV Drug Tenofovir
spellingShingle Chitosan-Based Mucoadhesive Vaginal Tablets for Controlled Release of the Anti-HIV Drug Tenofovir
Cazorla Luna, Raúl
615.4
Vaginal preexposure prophylaxis of HIV
Tenofovir controlled release
Mucoadhesive vaginal tablets
Natural polymers combination
Chitosan
Pectin
Locust bean gum
Tecnología farmaceútica
title_short Chitosan-Based Mucoadhesive Vaginal Tablets for Controlled Release of the Anti-HIV Drug Tenofovir
title_full Chitosan-Based Mucoadhesive Vaginal Tablets for Controlled Release of the Anti-HIV Drug Tenofovir
title_fullStr Chitosan-Based Mucoadhesive Vaginal Tablets for Controlled Release of the Anti-HIV Drug Tenofovir
title_full_unstemmed Chitosan-Based Mucoadhesive Vaginal Tablets for Controlled Release of the Anti-HIV Drug Tenofovir
title_sort Chitosan-Based Mucoadhesive Vaginal Tablets for Controlled Release of the Anti-HIV Drug Tenofovir
dc.creator.none.fl_str_mv Cazorla Luna, Raúl
Notario Pérez, Fernando
Martín Illana, Araceli
Ruiz Caro, Roberto
Tamayo, Aitana
Rubio, Juan
Veiga Ochoa, María Dolores
author Cazorla Luna, Raúl
author_facet Cazorla Luna, Raúl
Notario Pérez, Fernando
Martín Illana, Araceli
Ruiz Caro, Roberto
Tamayo, Aitana
Rubio, Juan
Veiga Ochoa, María Dolores
author_role author
author2 Notario Pérez, Fernando
Martín Illana, Araceli
Ruiz Caro, Roberto
Tamayo, Aitana
Rubio, Juan
Veiga Ochoa, María Dolores
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 615.4
Vaginal preexposure prophylaxis of HIV
Tenofovir controlled release
Mucoadhesive vaginal tablets
Natural polymers combination
Chitosan
Pectin
Locust bean gum
Tecnología farmaceútica
topic 615.4
Vaginal preexposure prophylaxis of HIV
Tenofovir controlled release
Mucoadhesive vaginal tablets
Natural polymers combination
Chitosan
Pectin
Locust bean gum
Tecnología farmaceútica
description Vaginal microbicides have the potential to give women at high risk of contracting HIV the option of self-protection by preventing the sexual transmission of the virus. In this paper, mucoadhesive vaginal tablets based on chitosan, alone and in combination with pectin and locust bean gum, were developed for the sustained release of tenofovir (an antiretroviral drug). The formulations were placed in simulant vaginal fluid (SVF) to swell, and Hg porosity and SEM microscopy were used for the microstructural characterization of the swelling witnesses. The results show that the association of pectin and chitosan generated polyelectrolyte complexes and produced a robust system able to maintain its structure during the swelling process, when small pores are formed. Drug reléase and bovine vaginal mucoadhesion studies were performed in SVF showing that tenofovir-controlled dissolution profiles and adhesion to the mucosa were conditioned by the swelling processes of the polymer/s in each formulation. Tablets based on chitosan/pectin have the most homogeneous tenofovir dissolution profiles and last up to 96 h, remaining attached to the vaginal mucosa for the same period. These formulations can therefore be considered a good option for the self-protection of women from the sexual transmission of HIV.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-01-01
2019
2019-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/12758
url https://hdl.handle.net/20.500.14352/12758
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869421379734994944
score 15,301603

Similares en LA Referencia