Feed additives for methane mitigation: A guideline to uncover the mode of action of antimethanogenic feed additives for ruminants

This publication aims to provide guidelines of the knowledge required and the potential research to be conducted in order to understand the mode of action of antimethanogenic feed additives (AMFA). In the first part of the paper, we classify AMFA into 4 categories according to their mode of action:...

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Authors: Belanche, A., Bannink, A., Dijkstra, J., Durmic, Z., Garcia, F., Santos, F.G., Huws, S., Jeyanathan, J., Lund, P., Mackie, R.I., McAllister, T.A., Morgavi, Diego P., Muetzel, S., Pitta, D.W., Yáñez Ruiz, David R., Ungerfeld, E.M.
Format: article
Status:Published version
Publication Date:2025
Country:España
Institution:Consejo Superior de Investigaciones Científicas (CSIC)
Repository:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/388233
Online Access:http://hdl.handle.net/10261/388233
Access Level:Open access
Keyword:Methanogens
Mitigation
Rumen methanogenesis
Rumen microbiota
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spelling Feed additives for methane mitigation: A guideline to uncover the mode of action of antimethanogenic feed additives for ruminantsBelanche, A.Bannink, A.Dijkstra, J.Durmic, Z.Garcia, F.Santos, F.G.Huws, S.Jeyanathan, J.Lund, P.Mackie, R.I.McAllister, T.A.Morgavi, Diego P.Muetzel, S.Pitta, D.W.Yáñez Ruiz, David R.Ungerfeld, E.M.MethanogensMitigationRumen methanogenesisRumen microbiotaThis publication aims to provide guidelines of the knowledge required and the potential research to be conducted in order to understand the mode of action of antimethanogenic feed additives (AMFA). In the first part of the paper, we classify AMFA into 4 categories according to their mode of action: (1) lowering dihydrogen (H) production; (2) inhibiting methanogens; (3) promoting alternative H-incorporating pathways; and (4) oxidizing methane (CH). The second part of the paper presents questions that guide the research to identify the mode of action of an AMFA on the rumen CH production from 5 different perspectives: (1) microbiology; (2) cell and molecular biochemistry; (3) microbial ecology; (4) animal metabolism; and (5) cross-cutting aspects. Recommendations are provided to address various research questions within each perspective, along with examples of how aspects of the mode of action of AMFA have been elucidated before. In summary, this paper offers timely and comprehensive guidelines to better understand and reveal the mode of action of current and emerging AMFA.The authors acknowledge the financial support of the Global Dairy Platform (Rosemont, IL) through its Pathways to Net Zero initiative. A. Belanche was funded by the Spanish State Research Agency (AEI) through a Ramón y Cajal research contract (AEI, Madrid, Spain; RYC2019-027764-I) and the project PID2021-12306OB-100. A. Bannink was funded by the Dutch Ministry of Agriculture, Nature and Food Quality (The Hague, Netherlands; Project Global Research Alliance; BO-43.10-001-001). F. Garcia was supported by the Global Dairy Platform (Des Plains, IL). Diego P. Morgavi acknowledges financial support from the European Union's Horizon 2020 research and innovation programme (Brussels, Belgium; grant agreement no. 101000213-HoloRuminant). D. R. Yáñez-Ruiz has received funding from the European Union's Horizon Europe research and innovation programme under the grant agreement No 01059609 (Re-Livestock project, European Commission funding; Brussels, Belgium). E. M. Ungerfeld acknowledges funding from Agencia Nacional de Investigación y Desarrollo (Santiago, Chile) Proyectos Fondecyt 1190574 and 1240264.Peer reviewedElsevierAmerican Dairy Science AssociationAgencia Estatal de Investigación (España)Ministry of Agriculture, Nature and Food Quality (The Netherlands)European CommissionFondo Nacional de Desarrollo Científico y Tecnológico (Chile)Yáñez-Ruiz, David R. [0000-0003-4397-3905]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2025202520252025info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/388233reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI//RYC2019-027764-Iinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-123060OB-I00info:eu-repo/grantAgreement/EC/H2020/01059609info:eu-repo/grantAgreement/EC/HE/01059609http://dx.doi.org/10.3168/jds.2024-25046Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3882332026-05-22T06:33:51Z
dc.title.none.fl_str_mv Feed additives for methane mitigation: A guideline to uncover the mode of action of antimethanogenic feed additives for ruminants
title Feed additives for methane mitigation: A guideline to uncover the mode of action of antimethanogenic feed additives for ruminants
spellingShingle Feed additives for methane mitigation: A guideline to uncover the mode of action of antimethanogenic feed additives for ruminants
Belanche, A.
Methanogens
Mitigation
Rumen methanogenesis
Rumen microbiota
title_short Feed additives for methane mitigation: A guideline to uncover the mode of action of antimethanogenic feed additives for ruminants
title_full Feed additives for methane mitigation: A guideline to uncover the mode of action of antimethanogenic feed additives for ruminants
title_fullStr Feed additives for methane mitigation: A guideline to uncover the mode of action of antimethanogenic feed additives for ruminants
title_full_unstemmed Feed additives for methane mitigation: A guideline to uncover the mode of action of antimethanogenic feed additives for ruminants
title_sort Feed additives for methane mitigation: A guideline to uncover the mode of action of antimethanogenic feed additives for ruminants
dc.creator.none.fl_str_mv Belanche, A.
Bannink, A.
Dijkstra, J.
Durmic, Z.
Garcia, F.
Santos, F.G.
Huws, S.
Jeyanathan, J.
Lund, P.
Mackie, R.I.
McAllister, T.A.
Morgavi, Diego P.
Muetzel, S.
Pitta, D.W.
Yáñez Ruiz, David R.
Ungerfeld, E.M.
author Belanche, A.
author_facet Belanche, A.
Bannink, A.
Dijkstra, J.
Durmic, Z.
Garcia, F.
Santos, F.G.
Huws, S.
Jeyanathan, J.
Lund, P.
Mackie, R.I.
McAllister, T.A.
Morgavi, Diego P.
Muetzel, S.
Pitta, D.W.
Yáñez Ruiz, David R.
Ungerfeld, E.M.
author_role author
author2 Bannink, A.
Dijkstra, J.
Durmic, Z.
Garcia, F.
Santos, F.G.
Huws, S.
Jeyanathan, J.
Lund, P.
Mackie, R.I.
McAllister, T.A.
Morgavi, Diego P.
Muetzel, S.
Pitta, D.W.
Yáñez Ruiz, David R.
Ungerfeld, E.M.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Agencia Estatal de Investigación (España)
Ministry of Agriculture, Nature and Food Quality (The Netherlands)
European Commission
Fondo Nacional de Desarrollo Científico y Tecnológico (Chile)
Yáñez-Ruiz, David R. [0000-0003-4397-3905]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Methanogens
Mitigation
Rumen methanogenesis
Rumen microbiota
topic Methanogens
Mitigation
Rumen methanogenesis
Rumen microbiota
description This publication aims to provide guidelines of the knowledge required and the potential research to be conducted in order to understand the mode of action of antimethanogenic feed additives (AMFA). In the first part of the paper, we classify AMFA into 4 categories according to their mode of action: (1) lowering dihydrogen (H) production; (2) inhibiting methanogens; (3) promoting alternative H-incorporating pathways; and (4) oxidizing methane (CH). The second part of the paper presents questions that guide the research to identify the mode of action of an AMFA on the rumen CH production from 5 different perspectives: (1) microbiology; (2) cell and molecular biochemistry; (3) microbial ecology; (4) animal metabolism; and (5) cross-cutting aspects. Recommendations are provided to address various research questions within each perspective, along with examples of how aspects of the mode of action of AMFA have been elucidated before. In summary, this paper offers timely and comprehensive guidelines to better understand and reveal the mode of action of current and emerging AMFA.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/388233
url http://hdl.handle.net/10261/388233
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
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info:eu-repo/grantAgreement/AEI//RYC2019-027764-I
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-123060OB-I00
info:eu-repo/grantAgreement/EC/H2020/01059609
info:eu-repo/grantAgreement/EC/HE/01059609
http://dx.doi.org/10.3168/jds.2024-25046
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
American Dairy Science Association
publisher.none.fl_str_mv Elsevier
American Dairy Science Association
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
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