Factor V Leiden and the 10-year incidence of depression: A retrospective cohort study conducted in Germany.

There is limited literature on the long-term relationship between the diagnosis of factor V Leiden (FVL) and depression. Therefore, the aim of this retrospective cohort study was to investigate the association between FVL and the 10-year incidence of depression in Germany. Patients diagnosed with FV...

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Autores: Jacob L, Jacob C, Koyanagi A, Smith L, Haro JM, Shin JI, Kostev K
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Fundació Sant Joan de Déu
Repositorio:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
OAI Identifier:oai:fsjd.fundanetsuite.com:p20529
Acceso en línea:https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=20529
Access Level:acceso abierto
Palabra clave:Depression
Epidemiology
Factor V Leiden
Germany
Retrospective cohort study
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spelling Factor V Leiden and the 10-year incidence of depression: A retrospective cohort study conducted in Germany.Jacob LJacob CKoyanagi ASmith LHaro JMShin JIKostev KDepressionEpidemiologyFactor V LeidenGermanyRetrospective cohort studyThere is limited literature on the long-term relationship between the diagnosis of factor V Leiden (FVL) and depression. Therefore, the aim of this retrospective cohort study was to investigate the association between FVL and the 10-year incidence of depression in Germany. Patients diagnosed with FVL for the first time in one of 1,274 general practices in Germany between 2000 and 2019 were included in this study (index date). Patients without FVL were matched (1:5) to those with FVL by sex, age, index year, and the average number of consultations per year. In individuals without FVL, index date corresponded to a randomly selected visit date between 2000 and 2019. The association between the diagnosis of FVL and the 10-year incidence of depression was analyzed using Kaplan-Meier curves and Cox regression models. This study included 1,070 patients with and 5,350 patients without FVL (64.9% women; 46.0 [16.5] years). Ten years after the index date, 21.4% and 14.1% of individuals with and without FVL were diagnosed with depression, respectively (log-rank p-value<0.001). After adjusting for thromboembolic events, the Cox regression analysis further showed that FVL was associated with a significant increase in the incidence of depression (HR = 1.61, 95% CI = 1.33-1.95). In this study conducted in Germany, FVL was identified as a long-term risk factor for depression. More research is needed to confirm or refute the present findings in other settings.PERGAMON-ELSEVIER SCIENCE LTD2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=20529JOURNAL OF PSYCHIATRIC RESEARCHISSN: 00223956ISSNe: 18791379reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déuinstname:Fundació Sant Joan de DéuInglésinfo:eu-repo/semantics/openAccessoai:fsjd.fundanetsuite.com:p205292026-05-27T12:37:41Z
dc.title.none.fl_str_mv Factor V Leiden and the 10-year incidence of depression: A retrospective cohort study conducted in Germany.
title Factor V Leiden and the 10-year incidence of depression: A retrospective cohort study conducted in Germany.
spellingShingle Factor V Leiden and the 10-year incidence of depression: A retrospective cohort study conducted in Germany.
Jacob L
Depression
Epidemiology
Factor V Leiden
Germany
Retrospective cohort study
title_short Factor V Leiden and the 10-year incidence of depression: A retrospective cohort study conducted in Germany.
title_full Factor V Leiden and the 10-year incidence of depression: A retrospective cohort study conducted in Germany.
title_fullStr Factor V Leiden and the 10-year incidence of depression: A retrospective cohort study conducted in Germany.
title_full_unstemmed Factor V Leiden and the 10-year incidence of depression: A retrospective cohort study conducted in Germany.
title_sort Factor V Leiden and the 10-year incidence of depression: A retrospective cohort study conducted in Germany.
dc.creator.none.fl_str_mv Jacob L
Jacob C
Koyanagi A
Smith L
Haro JM
Shin JI
Kostev K
author Jacob L
author_facet Jacob L
Jacob C
Koyanagi A
Smith L
Haro JM
Shin JI
Kostev K
author_role author
author2 Jacob C
Koyanagi A
Smith L
Haro JM
Shin JI
Kostev K
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Depression
Epidemiology
Factor V Leiden
Germany
Retrospective cohort study
topic Depression
Epidemiology
Factor V Leiden
Germany
Retrospective cohort study
description There is limited literature on the long-term relationship between the diagnosis of factor V Leiden (FVL) and depression. Therefore, the aim of this retrospective cohort study was to investigate the association between FVL and the 10-year incidence of depression in Germany. Patients diagnosed with FVL for the first time in one of 1,274 general practices in Germany between 2000 and 2019 were included in this study (index date). Patients without FVL were matched (1:5) to those with FVL by sex, age, index year, and the average number of consultations per year. In individuals without FVL, index date corresponded to a randomly selected visit date between 2000 and 2019. The association between the diagnosis of FVL and the 10-year incidence of depression was analyzed using Kaplan-Meier curves and Cox regression models. This study included 1,070 patients with and 5,350 patients without FVL (64.9% women; 46.0 [16.5] years). Ten years after the index date, 21.4% and 14.1% of individuals with and without FVL were diagnosed with depression, respectively (log-rank p-value<0.001). After adjusting for thromboembolic events, the Cox regression analysis further showed that FVL was associated with a significant increase in the incidence of depression (HR = 1.61, 95% CI = 1.33-1.95). In this study conducted in Germany, FVL was identified as a long-term risk factor for depression. More research is needed to confirm or refute the present findings in other settings.
publishDate 2022
dc.date.none.fl_str_mv 2022
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status_str publishedVersion
dc.identifier.none.fl_str_mv https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=20529
url https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=20529
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv PERGAMON-ELSEVIER SCIENCE LTD
publisher.none.fl_str_mv PERGAMON-ELSEVIER SCIENCE LTD
dc.source.none.fl_str_mv JOURNAL OF PSYCHIATRIC RESEARCH
ISSN: 00223956
ISSNe: 18791379
reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname:Fundació Sant Joan de Déu
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collection r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
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