Factors associated with discontinuation of biologics in patients with inflammatory arthritis in remission: data from the BIOBADASER registry

Biologic DMARD; Inflammatory arthritis; Remission

Detalles Bibliográficos
Autores: Valero Expósito, Marta, Sanchez-Piedra, Carlos, Freire, Mercedes, Colazo, María, Meriño-Ibarra, E, Busquets Pérez, Noemi
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Departament de Salut de la Generalitat de Catalunya (DS)
Repositorio:Scientia. Dipòsit d'Informació Digital del Departament de Salut
OAI Identifier:oai:scientiasalut.gencat.cat:11351/9908
Acceso en línea:https://hdl.handle.net/11351/9908
Access Level:acceso abierto
Palabra clave:Artritis
Medicina clínica - Investigació
Medicaments biològics
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Biological Therapy
DISEASES::Musculoskeletal Diseases::Joint Diseases::Arthritis
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Remission Induction
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::terapia biológica
ENFERMEDADES::enfermedades musculoesqueléticas::artropatías::artritis
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::inducción de remisión
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oai_identifier_str oai:scientiasalut.gencat.cat:11351/9908
network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv Factors associated with discontinuation of biologics in patients with inflammatory arthritis in remission: data from the BIOBADASER registry
title Factors associated with discontinuation of biologics in patients with inflammatory arthritis in remission: data from the BIOBADASER registry
spellingShingle Factors associated with discontinuation of biologics in patients with inflammatory arthritis in remission: data from the BIOBADASER registry
Valero Expósito, Marta
Artritis
Medicina clínica - Investigació
Medicaments biològics
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Biological Therapy
DISEASES::Musculoskeletal Diseases::Joint Diseases::Arthritis
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Remission Induction
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::terapia biológica
ENFERMEDADES::enfermedades musculoesqueléticas::artropatías::artritis
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::inducción de remisión
title_short Factors associated with discontinuation of biologics in patients with inflammatory arthritis in remission: data from the BIOBADASER registry
title_full Factors associated with discontinuation of biologics in patients with inflammatory arthritis in remission: data from the BIOBADASER registry
title_fullStr Factors associated with discontinuation of biologics in patients with inflammatory arthritis in remission: data from the BIOBADASER registry
title_full_unstemmed Factors associated with discontinuation of biologics in patients with inflammatory arthritis in remission: data from the BIOBADASER registry
title_sort Factors associated with discontinuation of biologics in patients with inflammatory arthritis in remission: data from the BIOBADASER registry
dc.creator.none.fl_str_mv Valero Expósito, Marta
Sanchez-Piedra, Carlos
Freire, Mercedes
Colazo, María
Meriño-Ibarra, E
Busquets Pérez, Noemi
author Valero Expósito, Marta
author_facet Valero Expósito, Marta
Sanchez-Piedra, Carlos
Freire, Mercedes
Colazo, María
Meriño-Ibarra, E
Busquets Pérez, Noemi
author_role author
author2 Sanchez-Piedra, Carlos
Freire, Mercedes
Colazo, María
Meriño-Ibarra, E
Busquets Pérez, Noemi
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv [Valero M] Servicio de Reumatología, Hospital Universitario Ramón Y Cajal Instituto Ramón Y Cajal de Investigación Sanitaria (IRYCIS), Carretera de Colmenar Viejo Km: 9,100, Madrid, Spain. [Sánchez-Piedra C] Health Technology Assessment Agency of Carlos III Institute of Health (ISCIII), Madrid, Spain. [Freire M] Department of Rheumatology, Complejo Hospitalario Universitario A Coruña, A Coruña, Spain. [Colazo M] Department of Rheumatology, Hospital Universitario de Burgos, Burgos, Spain. [Busquets N] Department of Rheumatology, Hospital General de Granollers, Granollers, Spain. [Meriño-Ibarra E] Department of Rheumatology, Hospital Universitario Miguel Servet, Saragossa, Spain
Hospital General de Granollers
dc.subject.none.fl_str_mv Artritis
Medicina clínica - Investigació
Medicaments biològics
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Biological Therapy
DISEASES::Musculoskeletal Diseases::Joint Diseases::Arthritis
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Remission Induction
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::terapia biológica
ENFERMEDADES::enfermedades musculoesqueléticas::artropatías::artritis
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::inducción de remisión
topic Artritis
Medicina clínica - Investigació
Medicaments biològics
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Biological Therapy
DISEASES::Musculoskeletal Diseases::Joint Diseases::Arthritis
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Remission Induction
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::terapia biológica
ENFERMEDADES::enfermedades musculoesqueléticas::artropatías::artritis
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::inducción de remisión
description Biologic DMARD; Inflammatory arthritis; Remission
publishDate 2023
dc.date.none.fl_str_mv 2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11351/9908
url https://hdl.handle.net/11351/9908
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Arthritis Research and Therapy;25
https://doi.org/10.1186/s13075-023-03045-3
dc.rights.none.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BMC
publisher.none.fl_str_mv BMC
dc.source.none.fl_str_mv Scientia
reponame:Scientia. Dipòsit d'Informació Digital del Departament de Salut
instname:Departament de Salut de la Generalitat de Catalunya (DS)
instname_str Departament de Salut de la Generalitat de Catalunya (DS)
reponame_str Scientia. Dipòsit d'Informació Digital del Departament de Salut
collection Scientia. Dipòsit d'Informació Digital del Departament de Salut
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869421317535563776
spelling Factors associated with discontinuation of biologics in patients with inflammatory arthritis in remission: data from the BIOBADASER registryValero Expósito, MartaSanchez-Piedra, CarlosFreire, MercedesColazo, MaríaMeriño-Ibarra, EBusquets Pérez, NoemiArtritisMedicina clínica - InvestigacióMedicaments biològicsANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Biological TherapyDISEASES::Musculoskeletal Diseases::Joint Diseases::ArthritisANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Remission InductionTÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::terapia biológicaENFERMEDADES::enfermedades musculoesqueléticas::artropatías::artritisTÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::inducción de remisiónBiologic DMARD; Inflammatory arthritis; RemissionFARME biológico; Artritis inflamatoria; RemisiónFARME biològic; Artritis inflamatòria; RemissióBackground: The objectives of this study were to assess the discontinuation of biologic therapy in patients who achieve remission and identify predictors of discontinuation of biologics in patients with inflammatory arthritis in remission. Methods: An observational retrospective study from the BIOBADASER registry comprising adult patients diagnosed with rheumatoid arthritis (RA), ankylosing spondylitis (AS), or psoriatic arthritis (PsA) and receiving 1 or 2 biological disease-modifying drugs (bDMARDs) between October 1999 and April 2021. Patients were followed yearly after initiation of therapy or until discontinuation of treatment. Reasons for discontinuation were collected. Patients who discontinued bDMARDs because of remission as defined by the attending clinician were studied. Predictors of discontinuation were explored using multivariable regression models. Results: The study population comprised 3,366 patients taking 1 or 2 bDMARDs. Biologics were discontinued owing to remission by 80 patients (2.4%): 30 with RA (1.7%), 18 with AS (2.4%), and 32 with PsA (3.9%). The factors associated with a higher probability of discontinuation on remission were shorter disease duration (OR: 0.95; 95% CI: 0.91-0.99), no concomitant use of classic DMARDs (OR: 0.56; 95% CI: 0.34-0.92), and shorter usage of the previous bDMARD (before the decision to discontinue biological therapy) (OR: 1.01; 95% CI: 1.01-1.02); in contrast, smoking status (OR: 2.48; 95% CI: 1.21-5.08) was associated with a lower probability. In patients with RA, positive ACPA was associated with a lower probability of discontinuation (OR: 0.11; 95% CI: 0.02-0.53). Conclusions: Discontinuation of bDMARDs in patients who achieve remission is uncommon in routine clinical care. Smoking and positive ACPA in RA patients were associated with a lower probability of treatment discontinuation because of clinical remission.BMC[Valero M] Servicio de Reumatología, Hospital Universitario Ramón Y Cajal Instituto Ramón Y Cajal de Investigación Sanitaria (IRYCIS), Carretera de Colmenar Viejo Km: 9,100, Madrid, Spain. [Sánchez-Piedra C] Health Technology Assessment Agency of Carlos III Institute of Health (ISCIII), Madrid, Spain. [Freire M] Department of Rheumatology, Complejo Hospitalario Universitario A Coruña, A Coruña, Spain. [Colazo M] Department of Rheumatology, Hospital Universitario de Burgos, Burgos, Spain. [Busquets N] Department of Rheumatology, Hospital General de Granollers, Granollers, Spain. [Meriño-Ibarra E] Department of Rheumatology, Hospital Universitario Miguel Servet, Saragossa, SpainHospital General de Granollers202320232023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11351/9908Scientiareponame:Scientia. Dipòsit d'Informació Digital del Departament de Salutinstname:Departament de Salut de la Generalitat de Catalunya (DS)InglésArthritis Research and Therapy;25https://doi.org/10.1186/s13075-023-03045-3Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:scientiasalut.gencat.cat:11351/99082026-06-12T09:38:37Z
score 15,812429

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