SARS-CoV-2 seroprevalence and preeclampsia markers in Mozambican pregnant women with perinatal loss.

Background SARS-CoV-2 infection during pregnancy is known to be associated with poor pregnancy outcomes, including pre-eclampsia (PE), prematurity, perinatal and maternal mortality. Data on the burden of SARS-CoV-2 infection among pregnant women and their offspring in Sub-Saharan Africa is limited....

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Autores: Chileshe, Maureen, Nhampossa, Tacilta, Carrilho Carla, Mendes, Anete, Luis, Elvira, Sacarlal, Jahit, Navero Castillejos, Jessica, Morales Ruiz, Manuel, Martínez Yoldi, Miguel Julián, Ordi i Majà, Jaume, Rakislova, Natalia, Menéndez, Clara, González Álvarez, Raquel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/227183
Acceso en línea:https://hdl.handle.net/2445/227183
Access Level:acceso abierto
Palabra clave:Complicacions en l'embaràs
COVID-19
Marcadors bioquímics
Complications of pregnancy
Biochemical markers
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spelling SARS-CoV-2 seroprevalence and preeclampsia markers in Mozambican pregnant women with perinatal loss.Chileshe, MaureenNhampossa, TaciltaCarrilho CarlaMendes, AneteLuis, ElviraSacarlal, JahitNavero Castillejos, JessicaMorales Ruiz, ManuelMartínez Yoldi, Miguel JuliánOrdi i Majà, JaumeRakislova, NataliaMenéndez, ClaraGonzález Álvarez, RaquelComplicacions en l'embaràsCOVID-19Marcadors bioquímicsComplications of pregnancyCOVID-19Biochemical markersBackground SARS-CoV-2 infection during pregnancy is known to be associated with poor pregnancy outcomes, including pre-eclampsia (PE), prematurity, perinatal and maternal mortality. Data on the burden of SARS-CoV-2 infection among pregnant women and their offspring in Sub-Saharan Africa is limited. We aimed to estimate SARS-CoV-2 seroprevalence and determine PE biomarkers in Mozambican pregnant women with perinatal loss. Methods A cross-sectional study was conducted among women who had a fetal or an early neonatal death at the Maputo Central Hospital (MCH), Mozambique. Anti-SARS-CoV-2 IgG/IgM were determined in maternal and umbilical cord blood and PE biomarkers (sFlt-1 and PIGF) in maternal blood. SARS-CoV-2 RT-PCR was performed in placenta and fetal lung biopsies from participants found to be SARS-CoV-2 seropositive. Results A total of 100 COVID-19 unvaccinated women were included in the study from March 2021 to April 2022. Total SARS-CoV-2 antibodies were detected in 68 [68%; 95CI (58 – 76)] maternal and 55 [55%; 95CI (54 – 74)] cord blood samples. SARS-CoV-2 IgM was detected in 18 cord blood samples and a positive placental RT-PCR in three of these participants. The proportion of women with moderate to high sFlt-1/PIGF ratio was higher in SARS-CoV-2 seropositive women than in those seronegative (71.2% vs 28.8%, p = 0.339), although the difference was not statistically significant. Conclusions SARS-CoV-2 seroprevalence among Mozambican women with perinatal loss was high during the second pandemic year, and there was evidence of vertical transmission in stillbirths. Findings also suggest that maternal SARS-CoV-2 infection may increase the risk of developing PE.BioMed Central2026202620242026info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion9 p.application/pdfhttps://hdl.handle.net/2445/227183Articles publicats en revistes (Biomedicina)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1186/s12884-024-06800-9BMC Pregnancy and Childbirth, 2024, vol. 24, num.1https://doi.org/10.1186/s12884-024-06800-9cc-by-nc-nd (c) Chileshe, M. et al., 2024http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2271832026-05-29T05:05:01Z
dc.title.none.fl_str_mv SARS-CoV-2 seroprevalence and preeclampsia markers in Mozambican pregnant women with perinatal loss.
title SARS-CoV-2 seroprevalence and preeclampsia markers in Mozambican pregnant women with perinatal loss.
spellingShingle SARS-CoV-2 seroprevalence and preeclampsia markers in Mozambican pregnant women with perinatal loss.
Chileshe, Maureen
Complicacions en l'embaràs
COVID-19
Marcadors bioquímics
Complications of pregnancy
COVID-19
Biochemical markers
title_short SARS-CoV-2 seroprevalence and preeclampsia markers in Mozambican pregnant women with perinatal loss.
title_full SARS-CoV-2 seroprevalence and preeclampsia markers in Mozambican pregnant women with perinatal loss.
title_fullStr SARS-CoV-2 seroprevalence and preeclampsia markers in Mozambican pregnant women with perinatal loss.
title_full_unstemmed SARS-CoV-2 seroprevalence and preeclampsia markers in Mozambican pregnant women with perinatal loss.
title_sort SARS-CoV-2 seroprevalence and preeclampsia markers in Mozambican pregnant women with perinatal loss.
dc.creator.none.fl_str_mv Chileshe, Maureen
Nhampossa, Tacilta
Carrilho Carla
Mendes, Anete
Luis, Elvira
Sacarlal, Jahit
Navero Castillejos, Jessica
Morales Ruiz, Manuel
Martínez Yoldi, Miguel Julián
Ordi i Majà, Jaume
Rakislova, Natalia
Menéndez, Clara
González Álvarez, Raquel
author Chileshe, Maureen
author_facet Chileshe, Maureen
Nhampossa, Tacilta
Carrilho Carla
Mendes, Anete
Luis, Elvira
Sacarlal, Jahit
Navero Castillejos, Jessica
Morales Ruiz, Manuel
Martínez Yoldi, Miguel Julián
Ordi i Majà, Jaume
Rakislova, Natalia
Menéndez, Clara
González Álvarez, Raquel
author_role author
author2 Nhampossa, Tacilta
Carrilho Carla
Mendes, Anete
Luis, Elvira
Sacarlal, Jahit
Navero Castillejos, Jessica
Morales Ruiz, Manuel
Martínez Yoldi, Miguel Julián
Ordi i Majà, Jaume
Rakislova, Natalia
Menéndez, Clara
González Álvarez, Raquel
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Complicacions en l'embaràs
COVID-19
Marcadors bioquímics
Complications of pregnancy
COVID-19
Biochemical markers
topic Complicacions en l'embaràs
COVID-19
Marcadors bioquímics
Complications of pregnancy
COVID-19
Biochemical markers
description Background SARS-CoV-2 infection during pregnancy is known to be associated with poor pregnancy outcomes, including pre-eclampsia (PE), prematurity, perinatal and maternal mortality. Data on the burden of SARS-CoV-2 infection among pregnant women and their offspring in Sub-Saharan Africa is limited. We aimed to estimate SARS-CoV-2 seroprevalence and determine PE biomarkers in Mozambican pregnant women with perinatal loss. Methods A cross-sectional study was conducted among women who had a fetal or an early neonatal death at the Maputo Central Hospital (MCH), Mozambique. Anti-SARS-CoV-2 IgG/IgM were determined in maternal and umbilical cord blood and PE biomarkers (sFlt-1 and PIGF) in maternal blood. SARS-CoV-2 RT-PCR was performed in placenta and fetal lung biopsies from participants found to be SARS-CoV-2 seropositive. Results A total of 100 COVID-19 unvaccinated women were included in the study from March 2021 to April 2022. Total SARS-CoV-2 antibodies were detected in 68 [68%; 95CI (58 – 76)] maternal and 55 [55%; 95CI (54 – 74)] cord blood samples. SARS-CoV-2 IgM was detected in 18 cord blood samples and a positive placental RT-PCR in three of these participants. The proportion of women with moderate to high sFlt-1/PIGF ratio was higher in SARS-CoV-2 seropositive women than in those seronegative (71.2% vs 28.8%, p = 0.339), although the difference was not statistically significant. Conclusions SARS-CoV-2 seroprevalence among Mozambican women with perinatal loss was high during the second pandemic year, and there was evidence of vertical transmission in stillbirths. Findings also suggest that maternal SARS-CoV-2 infection may increase the risk of developing PE.
publishDate 2024
dc.date.none.fl_str_mv 2024
2026
2026
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/227183
url https://hdl.handle.net/2445/227183
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1186/s12884-024-06800-9
BMC Pregnancy and Childbirth, 2024, vol. 24, num.1
https://doi.org/10.1186/s12884-024-06800-9
dc.rights.none.fl_str_mv cc-by-nc-nd (c) Chileshe, M. et al., 2024
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc-nd (c) Chileshe, M. et al., 2024
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 9 p.
application/pdf
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv Articles publicats en revistes (Biomedicina)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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