Invertebrate models for hyperthermia: What we learned from Caenorhabditis elegans and Hydra vulgaris
Animal models play critical roles in fundamental discovery and bioactivity testing to name some activities, and therefore, they represent an invaluable resource for biomedical research and for predicting the efficacy and toxicity of new therapeutic and diagnostic agents. The role of animal models is...
| Autores: | , , , , |
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| Tipo de recurso: | otro |
| Estado: | Versión aceptada para publicación |
| Fecha de publicación: | 2019 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/183943 |
| Acceso en línea: | http://hdl.handle.net/10261/183943 |
| Access Level: | acceso abierto |
| Palabra clave: | Nanoparticles Hydra vulgaris Optical hyperthermia Heat Invertebrate model organisms Caenorhabditis elegans Magnetic hyperthermia |
| Sumario: | Animal models play critical roles in fundamental discovery and bioactivity testing to name some activities, and therefore, they represent an invaluable resource for biomedical research and for predicting the efficacy and toxicity of new therapeutic and diagnostic agents. The role of animal models is crucial in many research fields, including the emerging nanomedicine, which demands not only accurate testing of novel medical nanomaterials, but also the study of the interaction between the nanomaterial and the biological target it was designed for. Model organisms provide scientists with a platform to perform biocompatibility, toxicity, and preclinical screening. Invertebrate models also address the 3Rs principle (replacement, reduction, and refinement) by reducing ethical concerns, economic costs, and the number of superior animals to be used in further studies. In this chapter, we will show the feasibility of using two promising invertebrate model animals, Caenorhabditis elegans and Hydra vulgaris, for both optical and magnetic hyperthermia studies. Following a brief introduction on the biology of both organisms presenting their advantages and limitations, we will overview their versatility to undergo multiple manipulations, hoping to provide the reader accurate criteria to select the most suitable animal model. Although we will limit our discussion to two models, we predict a significant overlap in mechanisms and concepts with other simple model organisms not discussed in this chapter. Therefore, the final aim of this chapter is to contribute to the safe design and screen of nanomaterials for hyperthermia, boosting its translation to clinical use. |
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