Design of Thermoplastic 3D-Printed Scaffolds for Bone Tissue Engineering: Influence of Parameters of ¿Hidden¿ Importance in the Physical Properties of Scaffolds

Additive manufacturing (AM) techniques are becoming the approaches of choice for the construction of scaolds in tissue engineering. However, the development of 3D printing in this field brings unique challenges, which must be accounted for in the design of experiments. The common printing process pa...

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Autores: Cubo-Mateo, Nieves, Rodríguez-Lorenzo, Luis M.
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/228676
Acceso en línea:http://hdl.handle.net/10261/228676
Access Level:acceso abierto
Palabra clave:Polycaprolactone
3D printing
Scaffolds
Bone engineering
Thermo-mechanical properties
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spelling Design of Thermoplastic 3D-Printed Scaffolds for Bone Tissue Engineering: Influence of Parameters of ¿Hidden¿ Importance in the Physical Properties of ScaffoldsCubo-Mateo, NievesRodríguez-Lorenzo, Luis M.Polycaprolactone3D printingScaffoldsBone engineeringThermo-mechanical propertiesAdditive manufacturing (AM) techniques are becoming the approaches of choice for the construction of scaolds in tissue engineering. However, the development of 3D printing in this field brings unique challenges, which must be accounted for in the design of experiments. The common printing process parameters must be considered as important factors in the design and quality of final 3D-printed products. In this work, we study the influence of some parameters in the design and fabrication of PCL scaolds, such as the number and orientation of layers, but also others of ¿hidden¿ importance, such as the cooling down rate while printing, or the position of the starting point in each layer. These factors can have an important impact oin the final porosity and mechanical performance of the scaolds. A pure polycaprolactone filament was used. Three dierent configurations were selected for the design of the internal structure of the scaolds: a solid one with alternate layers (solid) (0, 90), a porous one with 30% infill and alternate layers (ALT) (0, 90) and a non-alternated configuration consisting in printing three piled layers before changing the orientation (n-ALT) (0, 0, 0, 90, 90, 90). The nozzle temperature was set to 172 C for printing and the build plate to 40 C. Strand diameters of 361 26 m for room temperature cooling down and of 290 30 m for forced cooling down, were obtained. A compression elastic modulus of 2.12 0.31 MPa for n-ALT and 8.58 0.14 MPa for ALT scaolds were obtained. The cooling down rate has been observed as an important parameter for the final characteristics of the scaold.This project was funded by AEI/FEDER, UE project: DPI2017-90147-R.Multidisciplinary Digital Publishing InstituteEuropean CommissionConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2021202120202021info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501http://hdl.handle.net/10261/228676reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#DPI2017-90147-R.http://dx.doi.org/10.3390/polym12071546Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2286762026-05-22T06:33:51Z
dc.title.none.fl_str_mv Design of Thermoplastic 3D-Printed Scaffolds for Bone Tissue Engineering: Influence of Parameters of ¿Hidden¿ Importance in the Physical Properties of Scaffolds
title Design of Thermoplastic 3D-Printed Scaffolds for Bone Tissue Engineering: Influence of Parameters of ¿Hidden¿ Importance in the Physical Properties of Scaffolds
spellingShingle Design of Thermoplastic 3D-Printed Scaffolds for Bone Tissue Engineering: Influence of Parameters of ¿Hidden¿ Importance in the Physical Properties of Scaffolds
Cubo-Mateo, Nieves
Polycaprolactone
3D printing
Scaffolds
Bone engineering
Thermo-mechanical properties
title_short Design of Thermoplastic 3D-Printed Scaffolds for Bone Tissue Engineering: Influence of Parameters of ¿Hidden¿ Importance in the Physical Properties of Scaffolds
title_full Design of Thermoplastic 3D-Printed Scaffolds for Bone Tissue Engineering: Influence of Parameters of ¿Hidden¿ Importance in the Physical Properties of Scaffolds
title_fullStr Design of Thermoplastic 3D-Printed Scaffolds for Bone Tissue Engineering: Influence of Parameters of ¿Hidden¿ Importance in the Physical Properties of Scaffolds
title_full_unstemmed Design of Thermoplastic 3D-Printed Scaffolds for Bone Tissue Engineering: Influence of Parameters of ¿Hidden¿ Importance in the Physical Properties of Scaffolds
title_sort Design of Thermoplastic 3D-Printed Scaffolds for Bone Tissue Engineering: Influence of Parameters of ¿Hidden¿ Importance in the Physical Properties of Scaffolds
dc.creator.none.fl_str_mv Cubo-Mateo, Nieves
Rodríguez-Lorenzo, Luis M.
author Cubo-Mateo, Nieves
author_facet Cubo-Mateo, Nieves
Rodríguez-Lorenzo, Luis M.
author_role author
author2 Rodríguez-Lorenzo, Luis M.
author2_role author
dc.contributor.none.fl_str_mv European Commission
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Polycaprolactone
3D printing
Scaffolds
Bone engineering
Thermo-mechanical properties
topic Polycaprolactone
3D printing
Scaffolds
Bone engineering
Thermo-mechanical properties
description Additive manufacturing (AM) techniques are becoming the approaches of choice for the construction of scaolds in tissue engineering. However, the development of 3D printing in this field brings unique challenges, which must be accounted for in the design of experiments. The common printing process parameters must be considered as important factors in the design and quality of final 3D-printed products. In this work, we study the influence of some parameters in the design and fabrication of PCL scaolds, such as the number and orientation of layers, but also others of ¿hidden¿ importance, such as the cooling down rate while printing, or the position of the starting point in each layer. These factors can have an important impact oin the final porosity and mechanical performance of the scaolds. A pure polycaprolactone filament was used. Three dierent configurations were selected for the design of the internal structure of the scaolds: a solid one with alternate layers (solid) (0, 90), a porous one with 30% infill and alternate layers (ALT) (0, 90) and a non-alternated configuration consisting in printing three piled layers before changing the orientation (n-ALT) (0, 0, 0, 90, 90, 90). The nozzle temperature was set to 172 C for printing and the build plate to 40 C. Strand diameters of 361 26 m for room temperature cooling down and of 290 30 m for forced cooling down, were obtained. A compression elastic modulus of 2.12 0.31 MPa for n-ALT and 8.58 0.14 MPa for ALT scaolds were obtained. The cooling down rate has been observed as an important parameter for the final characteristics of the scaold.
publishDate 2020
dc.date.none.fl_str_mv 2020
2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/228676
url http://hdl.handle.net/10261/228676
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
DPI2017-90147-R.
http://dx.doi.org/10.3390/polym12071546
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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