The Influence of Body Mass Index on Clinical Interpretation of Established and Novel Biomarkers in Acute Heart Failure

Background: Body mass index (BMI) is a known confounder for natriuretic peptides, but its influence on other biomarkers is less well described. We investigated whether BMI interacts with biomarkers' association with prognosis in patients with acute heart failure (AHF).Methods and Results: B-typ...

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Authors: Horiuchi, Yu, Wettersten, Nicholas, van Veldhuisen, Dirk J, Mueller, Christian, Nowak, Richard, Hogan, Christopher, Kontos, Michael C, Cannon, Chad M, Birkhahn, Robert, Vilke, Gary M, Mahon, Niall, Nunez, Julio, Briguori, Carlo, Duff, Stephen, Murray, Patrick T, Maisel, Alan
Format: article
Status:Published version
Publication Date:2023
Country:España
Institution:INCLIVA
Repository:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
OAI Identifier:oai:incliva.fundanetsuite.com:p17446
Online Access:https://incliva.portalinvestigacion.com/publicaciones/17446
Access Level:Open access
Keyword:acute heart failure
body mass index
biomarker
natriuretic peptide
cardiac troponin
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spelling The Influence of Body Mass Index on Clinical Interpretation of Established and Novel Biomarkers in Acute Heart FailureHoriuchi, YuWettersten, Nicholasvan Veldhuisen, Dirk JMueller, ChristianNowak, RichardHogan, ChristopherKontos, Michael CCannon, Chad MBirkhahn, RobertVilke, Gary MMahon, NiallNunez, JulioBriguori, CarloDuff, StephenMurray, Patrick TMaisel, Alanacute heart failurebody mass indexbiomarkernatriuretic peptidecardiac troponinBackground: Body mass index (BMI) is a known confounder for natriuretic peptides, but its influence on other biomarkers is less well described. We investigated whether BMI interacts with biomarkers' association with prognosis in patients with acute heart failure (AHF).Methods and Results: B-type natriuretic peptide (BNP), high-sensitivity cardiac troponin I (hs-cTnI), galectin-3, serum neutrophil gelatinase-associated lipocalin (sNGAL), and urine NGAL were measured serially in patients with AHF during hospitalization in the AKINESIS (Acute Kidney Injury Neutrophil gelatinase-associated lipocalin Evaluation of Symptomatic Heart Failure) study. Cox regression analysis was used to determine the association of biomarkers and their interaction with BMI for 30-day, 90-day and 1-year composite outcomes of death or HF readmission. Among 866 patients, 21.2%, 29.7% and 46.8% had normal (18.5-24.9 kg/m(2)), overweight (25-29.9 kg/m(2)) or obese (= 30 kg/m(2)) BMIs on admission, respectively. Admission values of BNP and hs-cTnI were negatively associated with BMI, whereas galectin-3 and sNGAL were positively associated with BMI. Admission BNP and hs-cTnI levels were associated with the composite outcome within 30 days, 90 days and 1 year. Only BNP had a significant interaction with BMI. When BNP was analyzed by BMI category, its association with the composite outcome attenuated at higher BMIs and was no longer significant in obese individuals. Find-ings were similar when evaluated by the last-measured biomarkers and BMIs.Conclusions: In patients with AHF, only BNP had a significant interaction with BMI for the outcomes, with its association attenuating as BMI increased; hs-cTnI was prognostic, regard-less of BMI. (J Cardiac Fail 2023;29:1121-1131)CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://incliva.portalinvestigacion.com/publicaciones/17446JOURNAL OF CARDIAC FAILUREISSN: 10719164ISSNe: 15328414reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVAinstname:INCLIVAInglésinfo:eu-repo/semantics/openAccessoai:incliva.fundanetsuite.com:p174462026-06-07T16:35:31Z
dc.title.none.fl_str_mv The Influence of Body Mass Index on Clinical Interpretation of Established and Novel Biomarkers in Acute Heart Failure
title The Influence of Body Mass Index on Clinical Interpretation of Established and Novel Biomarkers in Acute Heart Failure
spellingShingle The Influence of Body Mass Index on Clinical Interpretation of Established and Novel Biomarkers in Acute Heart Failure
Horiuchi, Yu
acute heart failure
body mass index
biomarker
natriuretic peptide
cardiac troponin
title_short The Influence of Body Mass Index on Clinical Interpretation of Established and Novel Biomarkers in Acute Heart Failure
title_full The Influence of Body Mass Index on Clinical Interpretation of Established and Novel Biomarkers in Acute Heart Failure
title_fullStr The Influence of Body Mass Index on Clinical Interpretation of Established and Novel Biomarkers in Acute Heart Failure
title_full_unstemmed The Influence of Body Mass Index on Clinical Interpretation of Established and Novel Biomarkers in Acute Heart Failure
title_sort The Influence of Body Mass Index on Clinical Interpretation of Established and Novel Biomarkers in Acute Heart Failure
dc.creator.none.fl_str_mv Horiuchi, Yu
Wettersten, Nicholas
van Veldhuisen, Dirk J
Mueller, Christian
Nowak, Richard
Hogan, Christopher
Kontos, Michael C
Cannon, Chad M
Birkhahn, Robert
Vilke, Gary M
Mahon, Niall
Nunez, Julio
Briguori, Carlo
Duff, Stephen
Murray, Patrick T
Maisel, Alan
author Horiuchi, Yu
author_facet Horiuchi, Yu
Wettersten, Nicholas
van Veldhuisen, Dirk J
Mueller, Christian
Nowak, Richard
Hogan, Christopher
Kontos, Michael C
Cannon, Chad M
Birkhahn, Robert
Vilke, Gary M
Mahon, Niall
Nunez, Julio
Briguori, Carlo
Duff, Stephen
Murray, Patrick T
Maisel, Alan
author_role author
author2 Wettersten, Nicholas
van Veldhuisen, Dirk J
Mueller, Christian
Nowak, Richard
Hogan, Christopher
Kontos, Michael C
Cannon, Chad M
Birkhahn, Robert
Vilke, Gary M
Mahon, Niall
Nunez, Julio
Briguori, Carlo
Duff, Stephen
Murray, Patrick T
Maisel, Alan
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv acute heart failure
body mass index
biomarker
natriuretic peptide
cardiac troponin
topic acute heart failure
body mass index
biomarker
natriuretic peptide
cardiac troponin
description Background: Body mass index (BMI) is a known confounder for natriuretic peptides, but its influence on other biomarkers is less well described. We investigated whether BMI interacts with biomarkers' association with prognosis in patients with acute heart failure (AHF).Methods and Results: B-type natriuretic peptide (BNP), high-sensitivity cardiac troponin I (hs-cTnI), galectin-3, serum neutrophil gelatinase-associated lipocalin (sNGAL), and urine NGAL were measured serially in patients with AHF during hospitalization in the AKINESIS (Acute Kidney Injury Neutrophil gelatinase-associated lipocalin Evaluation of Symptomatic Heart Failure) study. Cox regression analysis was used to determine the association of biomarkers and their interaction with BMI for 30-day, 90-day and 1-year composite outcomes of death or HF readmission. Among 866 patients, 21.2%, 29.7% and 46.8% had normal (18.5-24.9 kg/m(2)), overweight (25-29.9 kg/m(2)) or obese (= 30 kg/m(2)) BMIs on admission, respectively. Admission values of BNP and hs-cTnI were negatively associated with BMI, whereas galectin-3 and sNGAL were positively associated with BMI. Admission BNP and hs-cTnI levels were associated with the composite outcome within 30 days, 90 days and 1 year. Only BNP had a significant interaction with BMI. When BNP was analyzed by BMI category, its association with the composite outcome attenuated at higher BMIs and was no longer significant in obese individuals. Find-ings were similar when evaluated by the last-measured biomarkers and BMIs.Conclusions: In patients with AHF, only BNP had a significant interaction with BMI for the outcomes, with its association attenuating as BMI increased; hs-cTnI was prognostic, regard-less of BMI. (J Cardiac Fail 2023;29:1121-1131)
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://incliva.portalinvestigacion.com/publicaciones/17446
url https://incliva.portalinvestigacion.com/publicaciones/17446
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS
publisher.none.fl_str_mv CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS
dc.source.none.fl_str_mv JOURNAL OF CARDIAC FAILURE
ISSN: 10719164
ISSNe: 15328414
reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
instname:INCLIVA
instname_str INCLIVA
reponame_str r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
collection r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812455

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