Optical grating coupler biosensor and biomedical applications
[eng] Biosensors are nowadays a powerful tool to enable the detection of specific biological interactions and to evaluate the concentration dependence in the response. A biosensor usually consists of three different parts: the sample to be measured, the transducer and the electronic system that ampl...
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| Tipo de recurso: | tesis doctoral |
| Estado: | Versión publicada |
| Fecha de publicación: | 2012 |
| País: | España |
| Institución: | Universidad de Barcelona |
| Repositorio: | Dipòsit Digital de la UB |
| OAI Identifier: | oai:diposit.ub.edu:2445/34962 |
| Acceso en línea: | https://hdl.handle.net/2445/34962 http://hdl.handle.net/10803/101149 |
| Access Level: | acceso abierto |
| Palabra clave: | Biosensors Detectors òptics Materials biomèdics Nanotecnologia Optical detectors Biomedical materials Nanotechnology |
| Sumario: | [eng] Biosensors are nowadays a powerful tool to enable the detection of specific biological interactions and to evaluate the concentration dependence in the response. A biosensor usually consists of three different parts: the sample to be measured, the transducer and the electronic system that amplifies the signal, analyzes the data and brings a result to the final user. The transducer includes the bioreceptor (which specifically interacts with the sample) and the interface that transforms the recognition from the bioreceptor into a measurable signal. When the analyte interacts with the bioreceptor, the transducer sends a signal that is processed by the electronics. All this process occurs in an efficient, quick, cheap, easy, simple and specific way. Regarding the type of the transductor, the biosensors can be electrochemical, optical, acoustic, magnetic or thermometric; but overall the most powerful ones are the optical biosensors, and among them the grating coupler. As a technique for investigating processes at the solid/liquid interface, presents high mechanical stability, immunity to electromagnetic interferences and pushes the sensitivity to levels even higher than other techniques and allows for the direct monitoring of macromolecular adsorption. Taking advantage of the last advances in nanotechnology, the goal of this thesis is to study the versatility of an Optical Grating Coupler Biosensor. The design of new grating sensor chips will be investigated, a new calibration technique for the sensors will be proposed and, taking advantage of the technique, different biomedical scenarios will be tested. |
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