CMV hyperimmune globulin as salvage therapy for recurrent or refractory CMV infection in children undergoing hematopoietic stem cell transplantation
Children; Cytomegalovirus; Hematopoietic stem cell transplantation
| Autores: | , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2023 |
| País: | España |
| Institución: | Departament de Salut de la Generalitat de Catalunya (DS) |
| Repositorio: | Scientia. Dipòsit d'Informació Digital del Departament de Salut |
| OAI Identifier: | oai:scientiasalut.gencat.cat:11351/10188 |
| Acceso en línea: | https://hdl.handle.net/11351/10188 |
| Access Level: | acceso abierto |
| Palabra clave: | Infeccions per citomegalovirus - Tractament Cèl·lules mare hematopoètiques - Trasplantació - Complicacions ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Biological Therapy::Cell- and Tissue-Based Therapy::Cell Transplantation::Stem Cell Transplantation::Hematopoietic Stem Cell Transplantation Other subheadings::Other subheadings::Other subheadings::/adverse effects DISEASES::Virus Diseases::DNA Virus Infections::Herpesviridae Infections::Cytomegalovirus Infections Other subheadings::Other subheadings::Other subheadings::/drug therapy TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::terapia biológica::tratamientos basados en células y tejidos::trasplante de células::trasplante de células madre::trasplante de células madre hematopoyéticas Otros calificadores::Otros calificadores::Otros calificadores::/efectos adversos ENFERMEDADES::virosis::infecciones por virus ADN::infecciones por Herpesviridae::infecciones por Citomegalovirus Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia |
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| dc.title.none.fl_str_mv |
CMV hyperimmune globulin as salvage therapy for recurrent or refractory CMV infection in children undergoing hematopoietic stem cell transplantation |
| title |
CMV hyperimmune globulin as salvage therapy for recurrent or refractory CMV infection in children undergoing hematopoietic stem cell transplantation |
| spellingShingle |
CMV hyperimmune globulin as salvage therapy for recurrent or refractory CMV infection in children undergoing hematopoietic stem cell transplantation Panesso Romero, Melissa Infeccions per citomegalovirus - Tractament Cèl·lules mare hematopoètiques - Trasplantació - Complicacions ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Biological Therapy::Cell- and Tissue-Based Therapy::Cell Transplantation::Stem Cell Transplantation::Hematopoietic Stem Cell Transplantation Other subheadings::Other subheadings::Other subheadings::/adverse effects DISEASES::Virus Diseases::DNA Virus Infections::Herpesviridae Infections::Cytomegalovirus Infections Other subheadings::Other subheadings::Other subheadings::/drug therapy TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::terapia biológica::tratamientos basados en células y tejidos::trasplante de células::trasplante de células madre::trasplante de células madre hematopoyéticas Otros calificadores::Otros calificadores::Otros calificadores::/efectos adversos ENFERMEDADES::virosis::infecciones por virus ADN::infecciones por Herpesviridae::infecciones por Citomegalovirus Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia |
| title_short |
CMV hyperimmune globulin as salvage therapy for recurrent or refractory CMV infection in children undergoing hematopoietic stem cell transplantation |
| title_full |
CMV hyperimmune globulin as salvage therapy for recurrent or refractory CMV infection in children undergoing hematopoietic stem cell transplantation |
| title_fullStr |
CMV hyperimmune globulin as salvage therapy for recurrent or refractory CMV infection in children undergoing hematopoietic stem cell transplantation |
| title_full_unstemmed |
CMV hyperimmune globulin as salvage therapy for recurrent or refractory CMV infection in children undergoing hematopoietic stem cell transplantation |
| title_sort |
CMV hyperimmune globulin as salvage therapy for recurrent or refractory CMV infection in children undergoing hematopoietic stem cell transplantation |
| dc.creator.none.fl_str_mv |
Panesso Romero, Melissa Uria Oficialdegui, Maria Luz Renedo-Miró, Berta Benitez Carabante, Maria Isabel Alonso Garcia, Laura Oliveras, María Mendoza-Palomar, Natalia Ana Esperalba, Juliana Diaz de Heredia, Cristina |
| author |
Panesso Romero, Melissa |
| author_facet |
Panesso Romero, Melissa Uria Oficialdegui, Maria Luz Renedo-Miró, Berta Benitez Carabante, Maria Isabel Alonso Garcia, Laura Oliveras, María Mendoza-Palomar, Natalia Ana Esperalba, Juliana Diaz de Heredia, Cristina |
| author_role |
author |
| author2 |
Uria Oficialdegui, Maria Luz Renedo-Miró, Berta Benitez Carabante, Maria Isabel Alonso Garcia, Laura Oliveras, María Mendoza-Palomar, Natalia Ana Esperalba, Juliana Diaz de Heredia, Cristina |
| author2_role |
author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Institut Català de la Salut [Panesso M, Uría ML, Benítez-Carabante MI, Alonso L, Diaz-de-Heredia C] Servei d'Hematologia i Oncologia Pediàtriques, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. [Renedo B, Oliveras M] Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Servei de Farmàcia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Esperalba J] Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Servei de Microbiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Mendoza-Palomar N] Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Unitat de Patologia Infecciosa i Immunodeficiències de Pediatria, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain Vall d'Hebron Barcelona Hospital Campus |
| dc.subject.none.fl_str_mv |
Infeccions per citomegalovirus - Tractament Cèl·lules mare hematopoètiques - Trasplantació - Complicacions ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Biological Therapy::Cell- and Tissue-Based Therapy::Cell Transplantation::Stem Cell Transplantation::Hematopoietic Stem Cell Transplantation Other subheadings::Other subheadings::Other subheadings::/adverse effects DISEASES::Virus Diseases::DNA Virus Infections::Herpesviridae Infections::Cytomegalovirus Infections Other subheadings::Other subheadings::Other subheadings::/drug therapy TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::terapia biológica::tratamientos basados en células y tejidos::trasplante de células::trasplante de células madre::trasplante de células madre hematopoyéticas Otros calificadores::Otros calificadores::Otros calificadores::/efectos adversos ENFERMEDADES::virosis::infecciones por virus ADN::infecciones por Herpesviridae::infecciones por Citomegalovirus Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia |
| topic |
Infeccions per citomegalovirus - Tractament Cèl·lules mare hematopoètiques - Trasplantació - Complicacions ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Biological Therapy::Cell- and Tissue-Based Therapy::Cell Transplantation::Stem Cell Transplantation::Hematopoietic Stem Cell Transplantation Other subheadings::Other subheadings::Other subheadings::/adverse effects DISEASES::Virus Diseases::DNA Virus Infections::Herpesviridae Infections::Cytomegalovirus Infections Other subheadings::Other subheadings::Other subheadings::/drug therapy TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::terapia biológica::tratamientos basados en células y tejidos::trasplante de células::trasplante de células madre::trasplante de células madre hematopoyéticas Otros calificadores::Otros calificadores::Otros calificadores::/efectos adversos ENFERMEDADES::virosis::infecciones por virus ADN::infecciones por Herpesviridae::infecciones por Citomegalovirus Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia |
| description |
Children; Cytomegalovirus; Hematopoietic stem cell transplantation |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023 2023 2023 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/11351/10188 |
| url |
https://hdl.handle.net/11351/10188 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Frontiers in Pediatrics;11 https://doi.org/10.3389/fped.2023.1197828 |
| dc.rights.none.fl_str_mv |
Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf application/pdf |
| dc.publisher.none.fl_str_mv |
Frontiers Media |
| publisher.none.fl_str_mv |
Frontiers Media |
| dc.source.none.fl_str_mv |
Scientia reponame:Scientia. Dipòsit d'Informació Digital del Departament de Salut instname:Departament de Salut de la Generalitat de Catalunya (DS) |
| instname_str |
Departament de Salut de la Generalitat de Catalunya (DS) |
| reponame_str |
Scientia. Dipòsit d'Informació Digital del Departament de Salut |
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Scientia. Dipòsit d'Informació Digital del Departament de Salut |
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| _version_ |
1869421237266022400 |
| spelling |
CMV hyperimmune globulin as salvage therapy for recurrent or refractory CMV infection in children undergoing hematopoietic stem cell transplantationPanesso Romero, MelissaUria Oficialdegui, Maria LuzRenedo-Miró, BertaBenitez Carabante, Maria IsabelAlonso Garcia, LauraOliveras, MaríaMendoza-Palomar, Natalia AnaEsperalba, JulianaDiaz de Heredia, CristinaInfeccions per citomegalovirus - TractamentCèl·lules mare hematopoètiques - Trasplantació - ComplicacionsANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Biological Therapy::Cell- and Tissue-Based Therapy::Cell Transplantation::Stem Cell Transplantation::Hematopoietic Stem Cell TransplantationOther subheadings::Other subheadings::Other subheadings::/adverse effectsDISEASES::Virus Diseases::DNA Virus Infections::Herpesviridae Infections::Cytomegalovirus InfectionsOther subheadings::Other subheadings::Other subheadings::/drug therapyTÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::terapia biológica::tratamientos basados en células y tejidos::trasplante de células::trasplante de células madre::trasplante de células madre hematopoyéticasOtros calificadores::Otros calificadores::Otros calificadores::/efectos adversosENFERMEDADES::virosis::infecciones por virus ADN::infecciones por Herpesviridae::infecciones por CitomegalovirusOtros calificadores::Otros calificadores::Otros calificadores::/farmacoterapiaChildren; Cytomegalovirus; Hematopoietic stem cell transplantationNens; Citomegalovirus; Trasplantament de cèl·lules mare hematopoètiquesNiños; Citomegalovirus; Trasplante de células madre hematopoyéticasCytomegalovirus (CMV) is a major cause of allogeneic hematopoietic stem cell transplant (HSCT)-related morbidity and mortality. Treatment failure continues to be a major issue in patients with CMV infection due to both drug resistance and intolerance. This single-center brief retrospective analysis of a case series aims to investigate the safety and efficacy of CMV-hyperimmune globulin as salvage therapy for CMV infection in children undergoing HSCT. Fifteen pediatric patients received human CMV-specific immunoglobulin (CMVIG) between July 2018 and December 2021 as a salvage therapy for refractory or recurrent CMV infection. At the time of CMVIG prescription, eight children presented with recurrent CMV infection and seven with refractory CMV infection. The overall response rate was 67% at 50 days from the CMVIG administration [95% confidence interval (CI): 44–88]. Overall survival (OS) from CMVIG administration at 100 days was 87% (95% CI: 56–96), and OS from HSCT at 1 year was 80% (95% CI: 50–93). Four patients died, three unrelated to CMV infection and one due to CMV pneumonia. CMVIG as salvage therapy was well tolerated, and no infusion-related adverse events were observed.Biotest supported the English revision of the manuscript.Frontiers MediaInstitut Català de la Salut[Panesso M, Uría ML, Benítez-Carabante MI, Alonso L, Diaz-de-Heredia C] Servei d'Hematologia i Oncologia Pediàtriques, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. [Renedo B, Oliveras M] Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Servei de Farmàcia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Esperalba J] Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Servei de Microbiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Mendoza-Palomar N] Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Unitat de Patologia Infecciosa i Immunodeficiències de Pediatria, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, SpainVall d'Hebron Barcelona Hospital Campus202320232023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11351/10188Scientiareponame:Scientia. Dipòsit d'Informació Digital del Departament de Salutinstname:Departament de Salut de la Generalitat de Catalunya (DS)InglésFrontiers in Pediatrics;11https://doi.org/10.3389/fped.2023.1197828Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:scientiasalut.gencat.cat:11351/101882026-06-12T09:38:37Z |
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15,811543 |