Cultured 3T3L1 adipocytes dispose of excess medium glucose as lactate under abundant oxygen availability

White adipose tissue (WAT) produces lactate in significant amount from circulating glucose, especially in obesity;Under normoxia, 3T3L1 cells secrete large quantities of lactate to the medium, again at the expense of glucose and proportionally to its levels. Most of the glucose was converted to lact...

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Autores: Sabater Martínez, David, Arriarán, Sofía, Romero Romero, María del Mar, Agnelli, Silvia, Fernández López, José Antonio, Remesar Betlloch, Xavier, Alemany, Marià, 1946-
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2014
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/52928
Acceso en línea:https://hdl.handle.net/2445/52928
Access Level:acceso abierto
Palabra clave:Teixit adipós
Glucosa
Cultius cel·lulars humans
Adipose tissues
Glucose
Human cell culture
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spelling Cultured 3T3L1 adipocytes dispose of excess medium glucose as lactate under abundant oxygen availabilitySabater Martínez, DavidArriarán, SofíaRomero Romero, María del MarAgnelli, SilviaFernández López, José AntonioRemesar Betlloch, XavierAlemany, Marià, 1946-Teixit adipósGlucosaCultius cel·lulars humansAdipose tissuesGlucoseHuman cell cultureWhite adipose tissue (WAT) produces lactate in significant amount from circulating glucose, especially in obesity;Under normoxia, 3T3L1 cells secrete large quantities of lactate to the medium, again at the expense of glucose and proportionally to its levels. Most of the glucose was converted to lactate with only part of it being used to synthesize fat. Cultured adipocytes were largely anaerobic, but this was not a Warburg-like process. It is speculated that the massive production of lactate, is a process of defense of the adipocyte, used to dispose of excess glucose. This way, the adipocyte exports glucose carbon (and reduces the problem of excess substrate availability) to the liver, but the process may be also a mechanism of short-term control of hyperglycemia. The in vivo data obtained from adipose tissue of male rats agree with this interpretation.Nature Publishing Group2014201420142014info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion21 p.application/pdfhttps://hdl.handle.net/2445/52928Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: http://dx.doi.org/10.1038/srep03663Scientific Reports, 2014, num. 4http://dx.doi.org/10.1038/srep03663cc-by-nc-nd (c) Sabater Martínez, David et al., 2014http://creativecommons.org/licenses/by-nc-nd/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/529282026-05-29T05:05:01Z
dc.title.none.fl_str_mv Cultured 3T3L1 adipocytes dispose of excess medium glucose as lactate under abundant oxygen availability
title Cultured 3T3L1 adipocytes dispose of excess medium glucose as lactate under abundant oxygen availability
spellingShingle Cultured 3T3L1 adipocytes dispose of excess medium glucose as lactate under abundant oxygen availability
Sabater Martínez, David
Teixit adipós
Glucosa
Cultius cel·lulars humans
Adipose tissues
Glucose
Human cell culture
title_short Cultured 3T3L1 adipocytes dispose of excess medium glucose as lactate under abundant oxygen availability
title_full Cultured 3T3L1 adipocytes dispose of excess medium glucose as lactate under abundant oxygen availability
title_fullStr Cultured 3T3L1 adipocytes dispose of excess medium glucose as lactate under abundant oxygen availability
title_full_unstemmed Cultured 3T3L1 adipocytes dispose of excess medium glucose as lactate under abundant oxygen availability
title_sort Cultured 3T3L1 adipocytes dispose of excess medium glucose as lactate under abundant oxygen availability
dc.creator.none.fl_str_mv Sabater Martínez, David
Arriarán, Sofía
Romero Romero, María del Mar
Agnelli, Silvia
Fernández López, José Antonio
Remesar Betlloch, Xavier
Alemany, Marià, 1946-
author Sabater Martínez, David
author_facet Sabater Martínez, David
Arriarán, Sofía
Romero Romero, María del Mar
Agnelli, Silvia
Fernández López, José Antonio
Remesar Betlloch, Xavier
Alemany, Marià, 1946-
author_role author
author2 Arriarán, Sofía
Romero Romero, María del Mar
Agnelli, Silvia
Fernández López, José Antonio
Remesar Betlloch, Xavier
Alemany, Marià, 1946-
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Teixit adipós
Glucosa
Cultius cel·lulars humans
Adipose tissues
Glucose
Human cell culture
topic Teixit adipós
Glucosa
Cultius cel·lulars humans
Adipose tissues
Glucose
Human cell culture
description White adipose tissue (WAT) produces lactate in significant amount from circulating glucose, especially in obesity;Under normoxia, 3T3L1 cells secrete large quantities of lactate to the medium, again at the expense of glucose and proportionally to its levels. Most of the glucose was converted to lactate with only part of it being used to synthesize fat. Cultured adipocytes were largely anaerobic, but this was not a Warburg-like process. It is speculated that the massive production of lactate, is a process of defense of the adipocyte, used to dispose of excess glucose. This way, the adipocyte exports glucose carbon (and reduces the problem of excess substrate availability) to the liver, but the process may be also a mechanism of short-term control of hyperglycemia. The in vivo data obtained from adipose tissue of male rats agree with this interpretation.
publishDate 2014
dc.date.none.fl_str_mv 2014
2014
2014
2014
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/52928
url https://hdl.handle.net/2445/52928
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: http://dx.doi.org/10.1038/srep03663
Scientific Reports, 2014, num. 4
http://dx.doi.org/10.1038/srep03663
dc.rights.none.fl_str_mv cc-by-nc-nd (c) Sabater Martínez, David et al., 2014
http://creativecommons.org/licenses/by-nc-nd/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc-nd (c) Sabater Martínez, David et al., 2014
http://creativecommons.org/licenses/by-nc-nd/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 21 p.
application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.81155

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