Neuroanatomical heterogeneity and homogeneity in individuals at clinical high risk for psychosis

Baldwin, Helen; Radua, Joaquim; Antoniades, Mathilde; Haas, Shalaila S.; Frangou, Sophia; Agartz, Ingrid; Allen, Paul; Andreassen, Ole A.; Atkinson, Kimberley; Bachman, Peter; Baeza, Inmaculada; Bartholomeusz, Cali F.; Chee, Michael W. L.; Colibazzi, Tiziano; Cooper, Rebecca E.; Corcoran, Cheryl M.; Cropley, Vanessa L.; Ebdrup, Bjørn H.; Fortea, Adriana; Glenthøj, Louise Birkedal; Hamilton, Holly K.; Haut, Kristen M.; Hayes, Rebecca A.; He, Ying; Heekeren, Karsteen; Kaess, Michael; Kasai, Kiyoto; Katagiri, Naoyuki; Kim, Minah; Kindler, Jochen; Klaunig, Mallory J.; Koike, Shinsuke; Koppel, Alex; Kristensen, Tina D.; Bin Kwak, Yoo; Kwon, Jun Soo; Lawrie, Stephen M.; Lebedeva, Irina; Lee, Jimmy; Lin, Ashleigh; Sugranyes, Gisela; Fusar Poli, Paolo; ENIGMA Clinical High Risk for Psychosis Working Group

Neuroanatomical heterogeneity and homogeneity in individuals at clinical high risk for psychosis

Individuals at Clinical High Risk for Psychosis (CHR-P) demonstrate heterogeneity in clinical profiles and outcome features. However, the extent of neuroanatomical heterogeneity in the CHR-P state is largely undetermined. We aimed to quantify the neuroanatomical heterogeneity in structural magnetic...

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Autores:	Baldwin, Helen, Radua, Joaquim, Antoniades, Mathilde, Haas, Shalaila S., Frangou, Sophia, Agartz, Ingrid, Allen, Paul, Andreassen, Ole A., Atkinson, Kimberley, Bachman, Peter, Baeza, Inmaculada, Bartholomeusz, Cali F., Chee, Michael W. L., Colibazzi, Tiziano, Cooper, Rebecca E., Corcoran, Cheryl M., Cropley, Vanessa L., Ebdrup, Bjørn H., Fortea, Adriana, Glenthøj, Louise Birkedal, Hamilton, Holly K., Haut, Kristen M., Hayes, Rebecca A., He, Ying, Heekeren, Karsteen, Kaess, Michael, Kasai, Kiyoto, Katagiri, Naoyuki, Kim, Minah, Kindler, Jochen, Klaunig, Mallory J., Koike, Shinsuke, Koppel, Alex, Kristensen, Tina D., Bin Kwak, Yoo, Kwon, Jun Soo, Lawrie, Stephen M., Lebedeva, Irina, Lee, Jimmy, Lin, Ashleigh, Sugranyes, Gisela, Fusar Poli, Paolo, ENIGMA Clinical High Risk for Psychosis Working Group
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2022
País:	España
Institución:	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:	Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:	oai:recercat.cat:2445/206255
Acceso en línea:	https://hdl.handle.net/2445/206255
Access Level:	acceso abierto
Palabra clave:	Imatges per ressonància magnètica Diagnòstic per la imatge Magnetic resonance imaging Diagnostic imaging

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spelling	Neuroanatomical heterogeneity and homogeneity in individuals at clinical high risk for psychosisBaldwin, HelenRadua, JoaquimAntoniades, MathildeHaas, Shalaila S.Frangou, SophiaAgartz, IngridAllen, PaulAndreassen, Ole A.Atkinson, KimberleyBachman, PeterBaeza, InmaculadaBartholomeusz, Cali F.Chee, Michael W. L.Colibazzi, TizianoCooper, Rebecca E.Corcoran, Cheryl M.Cropley, Vanessa L.Ebdrup, Bjørn H.Fortea, AdrianaGlenthøj, Louise BirkedalHamilton, Holly K.Haut, Kristen M.Hayes, Rebecca A.He, YingHeekeren, KarsteenKaess, MichaelKasai, KiyotoKatagiri, NaoyukiKim, MinahKindler, JochenKlaunig, Mallory J.Koike, ShinsukeKoppel, AlexKristensen, Tina D.Bin Kwak, YooKwon, Jun SooLawrie, Stephen M.Lebedeva, IrinaLee, JimmyLin, AshleighSugranyes, GiselaFusar Poli, PaoloENIGMA Clinical High Risk for Psychosis Working GroupImatges per ressonància magnèticaDiagnòstic per la imatgeMagnetic resonance imagingDiagnostic imagingIndividuals at Clinical High Risk for Psychosis (CHR-P) demonstrate heterogeneity in clinical profiles and outcome features. However, the extent of neuroanatomical heterogeneity in the CHR-P state is largely undetermined. We aimed to quantify the neuroanatomical heterogeneity in structural magnetic resonance imaging measures of cortical surface area (SA), cortical thickness (CT), subcortical volume (SV), and intracranial volume (ICV) in CHR-P individuals compared with healthy controls (HC), and in relation to subsequent transition to a first episode of psychosis. The ENIGMA CHR-P consortium applied a harmonised analysis to neuroimaging data across 29 international sites, including 1579 CHR-P individuals and 1243 HC, offering the largest pooled CHR-P neuroimaging dataset to date. Regional heterogeneity was indexed with the Variability Ratio (VR) and Coefficient of Variation (CV) ratio applied at the group level. Personalised estimates of heterogeneity of SA, CT and SV brain profiles were indexed with the novel Person-Based Similarity Index (PBSI), with two complementary applications. First, to assess the extent of within-diagnosis similarity or divergence of neuroanatomical profiles between individuals. Second, using a normative modelling approach, to assess the 'normativeness' of neuroanatomical profiles in individuals at CHR-P. CHR-P individuals demonstrated no greater regional heterogeneity after applying FDR corrections. However, PBSI scores indicated significantly greater neuroanatomical divergence in global SA, CT and SV profiles in CHR-P individuals compared with HC. Normative PBSI analysis identified 11 CHR-P individuals (0.70%) with marked deviation (>1.5?SD) in SA, 118 (7.47%) in CT and 161 (10.20%) in SV. Psychosis transition was not significantly associated with any measure of heterogeneity. Overall, our examination of neuroanatomical heterogeneity within the CHR-P state indicated greater divergence in neuroanatomical profiles at an individual level, irrespective of psychosis conversion. Further large-scale investigations are required of those who demonstrate marked deviation.© 2022. The Author(s).Springer Nature2024202420222023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion11 p.application/pdfhttps://hdl.handle.net/2445/206255Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1038/s41398-022-02057-yTranslational Psychiatry, 2022, vol. 12, num. 1, p. 297https://doi.org/10.1038/s41398-022-02057-ycc by (c) Baldwin, H. et al., 2022http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2062552026-05-29T05:05:01Z
dc.title.none.fl_str_mv	Neuroanatomical heterogeneity and homogeneity in individuals at clinical high risk for psychosis
title	Neuroanatomical heterogeneity and homogeneity in individuals at clinical high risk for psychosis
spellingShingle	Neuroanatomical heterogeneity and homogeneity in individuals at clinical high risk for psychosis Baldwin, Helen Imatges per ressonància magnètica Diagnòstic per la imatge Magnetic resonance imaging Diagnostic imaging
title_short	Neuroanatomical heterogeneity and homogeneity in individuals at clinical high risk for psychosis
title_full	Neuroanatomical heterogeneity and homogeneity in individuals at clinical high risk for psychosis
title_fullStr	Neuroanatomical heterogeneity and homogeneity in individuals at clinical high risk for psychosis
title_full_unstemmed	Neuroanatomical heterogeneity and homogeneity in individuals at clinical high risk for psychosis
title_sort	Neuroanatomical heterogeneity and homogeneity in individuals at clinical high risk for psychosis
dc.creator.none.fl_str_mv	Baldwin, Helen Radua, Joaquim Antoniades, Mathilde Haas, Shalaila S. Frangou, Sophia Agartz, Ingrid Allen, Paul Andreassen, Ole A. Atkinson, Kimberley Bachman, Peter Baeza, Inmaculada Bartholomeusz, Cali F. Chee, Michael W. L. Colibazzi, Tiziano Cooper, Rebecca E. Corcoran, Cheryl M. Cropley, Vanessa L. Ebdrup, Bjørn H. Fortea, Adriana Glenthøj, Louise Birkedal Hamilton, Holly K. Haut, Kristen M. Hayes, Rebecca A. He, Ying Heekeren, Karsteen Kaess, Michael Kasai, Kiyoto Katagiri, Naoyuki Kim, Minah Kindler, Jochen Klaunig, Mallory J. Koike, Shinsuke Koppel, Alex Kristensen, Tina D. Bin Kwak, Yoo Kwon, Jun Soo Lawrie, Stephen M. Lebedeva, Irina Lee, Jimmy Lin, Ashleigh Sugranyes, Gisela Fusar Poli, Paolo ENIGMA Clinical High Risk for Psychosis Working Group
author	Baldwin, Helen
author_facet	Baldwin, Helen Radua, Joaquim Antoniades, Mathilde Haas, Shalaila S. Frangou, Sophia Agartz, Ingrid Allen, Paul Andreassen, Ole A. Atkinson, Kimberley Bachman, Peter Baeza, Inmaculada Bartholomeusz, Cali F. Chee, Michael W. L. Colibazzi, Tiziano Cooper, Rebecca E. Corcoran, Cheryl M. Cropley, Vanessa L. Ebdrup, Bjørn H. Fortea, Adriana Glenthøj, Louise Birkedal Hamilton, Holly K. Haut, Kristen M. Hayes, Rebecca A. He, Ying Heekeren, Karsteen Kaess, Michael Kasai, Kiyoto Katagiri, Naoyuki Kim, Minah Kindler, Jochen Klaunig, Mallory J. Koike, Shinsuke Koppel, Alex Kristensen, Tina D. Bin Kwak, Yoo Kwon, Jun Soo Lawrie, Stephen M. Lebedeva, Irina Lee, Jimmy Lin, Ashleigh Sugranyes, Gisela Fusar Poli, Paolo ENIGMA Clinical High Risk for Psychosis Working Group
author_role	author
author2	Radua, Joaquim Antoniades, Mathilde Haas, Shalaila S. Frangou, Sophia Agartz, Ingrid Allen, Paul Andreassen, Ole A. Atkinson, Kimberley Bachman, Peter Baeza, Inmaculada Bartholomeusz, Cali F. Chee, Michael W. L. Colibazzi, Tiziano Cooper, Rebecca E. Corcoran, Cheryl M. Cropley, Vanessa L. Ebdrup, Bjørn H. Fortea, Adriana Glenthøj, Louise Birkedal Hamilton, Holly K. Haut, Kristen M. Hayes, Rebecca A. He, Ying Heekeren, Karsteen Kaess, Michael Kasai, Kiyoto Katagiri, Naoyuki Kim, Minah Kindler, Jochen Klaunig, Mallory J. Koike, Shinsuke Koppel, Alex Kristensen, Tina D. Bin Kwak, Yoo Kwon, Jun Soo Lawrie, Stephen M. Lebedeva, Irina Lee, Jimmy Lin, Ashleigh Sugranyes, Gisela Fusar Poli, Paolo ENIGMA Clinical High Risk for Psychosis Working Group
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	Imatges per ressonància magnètica Diagnòstic per la imatge Magnetic resonance imaging Diagnostic imaging
topic	Imatges per ressonància magnètica Diagnòstic per la imatge Magnetic resonance imaging Diagnostic imaging
description	Individuals at Clinical High Risk for Psychosis (CHR-P) demonstrate heterogeneity in clinical profiles and outcome features. However, the extent of neuroanatomical heterogeneity in the CHR-P state is largely undetermined. We aimed to quantify the neuroanatomical heterogeneity in structural magnetic resonance imaging measures of cortical surface area (SA), cortical thickness (CT), subcortical volume (SV), and intracranial volume (ICV) in CHR-P individuals compared with healthy controls (HC), and in relation to subsequent transition to a first episode of psychosis. The ENIGMA CHR-P consortium applied a harmonised analysis to neuroimaging data across 29 international sites, including 1579 CHR-P individuals and 1243 HC, offering the largest pooled CHR-P neuroimaging dataset to date. Regional heterogeneity was indexed with the Variability Ratio (VR) and Coefficient of Variation (CV) ratio applied at the group level. Personalised estimates of heterogeneity of SA, CT and SV brain profiles were indexed with the novel Person-Based Similarity Index (PBSI), with two complementary applications. First, to assess the extent of within-diagnosis similarity or divergence of neuroanatomical profiles between individuals. Second, using a normative modelling approach, to assess the 'normativeness' of neuroanatomical profiles in individuals at CHR-P. CHR-P individuals demonstrated no greater regional heterogeneity after applying FDR corrections. However, PBSI scores indicated significantly greater neuroanatomical divergence in global SA, CT and SV profiles in CHR-P individuals compared with HC. Normative PBSI analysis identified 11 CHR-P individuals (0.70%) with marked deviation (>1.5?SD) in SA, 118 (7.47%) in CT and 161 (10.20%) in SV. Psychosis transition was not significantly associated with any measure of heterogeneity. Overall, our examination of neuroanatomical heterogeneity within the CHR-P state indicated greater divergence in neuroanatomical profiles at an individual level, irrespective of psychosis conversion. Further large-scale investigations are required of those who demonstrate marked deviation.© 2022. The Author(s).
publishDate	2022
dc.date.none.fl_str_mv	2022 2023 2024 2024
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	https://hdl.handle.net/2445/206255
url	https://hdl.handle.net/2445/206255
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.relation.none.fl_str_mv	Reproducció del document publicat a: https://doi.org/10.1038/s41398-022-02057-y Translational Psychiatry, 2022, vol. 12, num. 1, p. 297 https://doi.org/10.1038/s41398-022-02057-y
dc.rights.none.fl_str_mv	cc by (c) Baldwin, H. et al., 2022 http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess
rights_invalid_str_mv	cc by (c) Baldwin, H. et al., 2022 http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	11 p. application/pdf
dc.publisher.none.fl_str_mv	Springer Nature
publisher.none.fl_str_mv	Springer Nature
dc.source.none.fl_str_mv	Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str	Recercat. Dipósit de la Recerca de Catalunya
collection	Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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Neuroanatomical heterogeneity and homogeneity in individuals at clinical high risk for psychosis

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