Fecal immunochemical test for hemoglobin versus fecal calprotectin to monitor endoscopic activity in inflammatory bowel disease

Cross-sectional prospective observational study that aims to compare the usefulness of fecal immunochemical test (FIT) versus fecal calprotectin (FC) to determine endoscopic activity in patients with inflammatory bowel disease (IBD).In patients with IBD, FIT and FC showed a significant correlation w...

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Autores: Latorre Añó P, Torrente Sánchez J, Pérez Ibañez AA, Tenias Burillo JM, Moreno Sánchez NP, López-Serrano A, Moreno Osset E, Murado Pardo J, Paredes JM
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Repositorio:r-FISABIO. Repositorio Institucional de Producción Científica
OAI Identifier:oai:fisabio.fundanetsuite.com:p15172
Acceso en línea:https://fisabio.portalinvestigacion.com/publicaciones/15172
Access Level:acceso abierto
Palabra clave:Fecal immunochemical test
Haemoglobin
Fecal calprotectin
Inflammatory bowel disease
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spelling Fecal immunochemical test for hemoglobin versus fecal calprotectin to monitor endoscopic activity in inflammatory bowel diseaseLatorre Añó PTorrente Sánchez JPérez Ibañez AATenias Burillo JMMoreno Sánchez NPLópez-Serrano AMoreno Osset EMurado Pardo JParedes JMFecal immunochemical testHaemoglobinFecal calprotectinInflammatory bowel diseaseCross-sectional prospective observational study that aims to compare the usefulness of fecal immunochemical test (FIT) versus fecal calprotectin (FC) to determine endoscopic activity in patients with inflammatory bowel disease (IBD).In patients with IBD, FIT and FC showed a significant correlation with the presence of inflammatory activity/mucosal healing (MH) on endoscopy, without statistically significant differences. Both tests improved their diagnostic performance when assessing patients with UC and worsens in Crohn's disease (CD).In conclusion, FIT is an alternative to monitor endoscopic activity among UC patients. Aim: endoscopy identifies inflammatory activity, however, it is an unpleasant test and is not always accessible. The aim of the study was to compare the usefulness of quantitative fecal immunochemical test (FIT) versus fecal calprotectin (FC) to determine endoscopic activity in patients with inflammatory bowel disease (IBD). Methods: cross-sectional prospective observational study. The stool samples were collected within three days before starting the preparation for the colonoscopy. We used the Mayo index for ulcerative colitis (UC) and the simplified endoscopic index for Crohn's disease (CD). Mucosal healing (MH) was defined as the score 0 points in each of the endoscopic indices. Results: eighty-four patients were included, 40 (47.6 %) with UC. In patients with IBD, FIT and FC showed a significant correlation with the presence of inflammatory activity/MH on endoscopy, with no statistically significant differences between the two receiver-operating characteristic (ROC) curves. Both tests improved their diagnostic performance when assessing patients with UC; the Spearman correlations between FIT and FC and endoscopic inflammatory activity were r = 0.6 (p = 0.0001) and r = 0.7 (p = 0.0001), respectively. In Crohn's disease, the diagnostic utility of both tests was lower. Conclusions: FIT is an alternative to monitor endoscopic activity among ulcerative colitis patients. In Crohn's disease, more studies are needed to determine the role of fecal biomarkers.ARAN EDICIONES, S A2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fisabio.portalinvestigacion.com/publicaciones/15172REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVASISSN: 11300108ISSNe: 23404167reponame:r-FISABIO. Repositorio Institucional de Producción Científicainstname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)Españolinfo:eu-repo/semantics/openAccessoai:fisabio.fundanetsuite.com:p151722026-06-11T12:45:17Z
dc.title.none.fl_str_mv Fecal immunochemical test for hemoglobin versus fecal calprotectin to monitor endoscopic activity in inflammatory bowel disease
title Fecal immunochemical test for hemoglobin versus fecal calprotectin to monitor endoscopic activity in inflammatory bowel disease
spellingShingle Fecal immunochemical test for hemoglobin versus fecal calprotectin to monitor endoscopic activity in inflammatory bowel disease
Latorre Añó P
Fecal immunochemical test
Haemoglobin
Fecal calprotectin
Inflammatory bowel disease
title_short Fecal immunochemical test for hemoglobin versus fecal calprotectin to monitor endoscopic activity in inflammatory bowel disease
title_full Fecal immunochemical test for hemoglobin versus fecal calprotectin to monitor endoscopic activity in inflammatory bowel disease
title_fullStr Fecal immunochemical test for hemoglobin versus fecal calprotectin to monitor endoscopic activity in inflammatory bowel disease
title_full_unstemmed Fecal immunochemical test for hemoglobin versus fecal calprotectin to monitor endoscopic activity in inflammatory bowel disease
title_sort Fecal immunochemical test for hemoglobin versus fecal calprotectin to monitor endoscopic activity in inflammatory bowel disease
dc.creator.none.fl_str_mv Latorre Añó P
Torrente Sánchez J
Pérez Ibañez AA
Tenias Burillo JM
Moreno Sánchez NP
López-Serrano A
Moreno Osset E
Murado Pardo J
Paredes JM
author Latorre Añó P
author_facet Latorre Añó P
Torrente Sánchez J
Pérez Ibañez AA
Tenias Burillo JM
Moreno Sánchez NP
López-Serrano A
Moreno Osset E
Murado Pardo J
Paredes JM
author_role author
author2 Torrente Sánchez J
Pérez Ibañez AA
Tenias Burillo JM
Moreno Sánchez NP
López-Serrano A
Moreno Osset E
Murado Pardo J
Paredes JM
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Fecal immunochemical test
Haemoglobin
Fecal calprotectin
Inflammatory bowel disease
topic Fecal immunochemical test
Haemoglobin
Fecal calprotectin
Inflammatory bowel disease
description Cross-sectional prospective observational study that aims to compare the usefulness of fecal immunochemical test (FIT) versus fecal calprotectin (FC) to determine endoscopic activity in patients with inflammatory bowel disease (IBD).In patients with IBD, FIT and FC showed a significant correlation with the presence of inflammatory activity/mucosal healing (MH) on endoscopy, without statistically significant differences. Both tests improved their diagnostic performance when assessing patients with UC and worsens in Crohn's disease (CD).In conclusion, FIT is an alternative to monitor endoscopic activity among UC patients. Aim: endoscopy identifies inflammatory activity, however, it is an unpleasant test and is not always accessible. The aim of the study was to compare the usefulness of quantitative fecal immunochemical test (FIT) versus fecal calprotectin (FC) to determine endoscopic activity in patients with inflammatory bowel disease (IBD). Methods: cross-sectional prospective observational study. The stool samples were collected within three days before starting the preparation for the colonoscopy. We used the Mayo index for ulcerative colitis (UC) and the simplified endoscopic index for Crohn's disease (CD). Mucosal healing (MH) was defined as the score 0 points in each of the endoscopic indices. Results: eighty-four patients were included, 40 (47.6 %) with UC. In patients with IBD, FIT and FC showed a significant correlation with the presence of inflammatory activity/MH on endoscopy, with no statistically significant differences between the two receiver-operating characteristic (ROC) curves. Both tests improved their diagnostic performance when assessing patients with UC; the Spearman correlations between FIT and FC and endoscopic inflammatory activity were r = 0.6 (p = 0.0001) and r = 0.7 (p = 0.0001), respectively. In Crohn's disease, the diagnostic utility of both tests was lower. Conclusions: FIT is an alternative to monitor endoscopic activity among ulcerative colitis patients. In Crohn's disease, more studies are needed to determine the role of fecal biomarkers.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fisabio.portalinvestigacion.com/publicaciones/15172
url https://fisabio.portalinvestigacion.com/publicaciones/15172
dc.language.none.fl_str_mv Español
language_invalid_str_mv Español
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv ARAN EDICIONES, S A
publisher.none.fl_str_mv ARAN EDICIONES, S A
dc.source.none.fl_str_mv REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS
ISSN: 11300108
ISSNe: 23404167
reponame:r-FISABIO. Repositorio Institucional de Producción Científica
instname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
instname_str Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
reponame_str r-FISABIO. Repositorio Institucional de Producción Científica
collection r-FISABIO. Repositorio Institucional de Producción Científica
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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