Effect of pulmonary hypertension on exercise tolerance in patients with COPD: a prognostic systematic review and meta-analysis

Background: Pulmonary hypertension (PH) is a frequent complication in patients with COPD. Objective: To determine if, in patients with COPD, the presence of PH decreases exercise tolerance. Methods: We included studies that analysed exercise tolerance using a cardiopulmonary exercise test (CPET) in...

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Autores: Torres Castro, Rodrigo, Gimeno Santos, Elena, 1980-, Vilaró, Jordi, Roqué Figuls, Marta, Moisés, Jorge, Vasconcello Castillo, Luis, Orizaga, Tanya, Barberà i Mir, Joan Albert, Blanco Vich, Isabel
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Recursos:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/183674
Acesso em linha:https://hdl.handle.net/2445/183674
Access Level:acceso abierto
Palavra-chave:Malalties pulmonars obstructives cròniques
Hipertensió pulmonar
Chronic obstructive pulmonary diseases
Pulmonary hypertension
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spelling Effect of pulmonary hypertension on exercise tolerance in patients with COPD: a prognostic systematic review and meta-analysisTorres Castro, RodrigoGimeno Santos, Elena, 1980-Vilaró, JordiRoqué Figuls, MartaMoisés, JorgeVasconcello Castillo, LuisOrizaga, TanyaBarberà i Mir, Joan AlbertBlanco Vich, IsabelMalalties pulmonars obstructives cròniquesHipertensió pulmonarChronic obstructive pulmonary diseasesPulmonary hypertensionBackground: Pulmonary hypertension (PH) is a frequent complication in patients with COPD. Objective: To determine if, in patients with COPD, the presence of PH decreases exercise tolerance. Methods: We included studies that analysed exercise tolerance using a cardiopulmonary exercise test (CPET) in patients with COPD with PH (COPD-PH) and without PH (COPD-nonPH). Two independent reviewers analysed the studies, extracted the data and assessed the quality of the evidence. Results: Of the 4915 articles initially identified, seven reported 257 patients with COPD-PH and 404 patients with COPD-nonPH. The COPD-PH group showed differences in peak oxygen consumption (V'O2peak ), -3.09 mL·kg-1·min-1 (95% CI -4.74 to -1.43, p=0.0003); maximum workload (Wmax), -20.5 W (95% CI -34.4 to -6.5, p=0.004); and oxygen pulse (O2 pulse), -1.24 mL·beat-1 (95% CI -2.40 to -0.09, p=0.03), in comparison to the group with COPD-nonPH. If we excluded studies with lung transplant candidates, the sensitivity analyses showed even bigger differences: V'O2 , -4.26 mL·min-1·kg-1 (95% CI -5.50 to -3.02 mL·kg-1·min-1, p<0.00001); Wmax, -26.6 W (95% CI -32.1 to -21.1 W, p<0.00001); and O2 pulse, -2.04 mL·beat-1 (95% CI -2.92 to -1.15 mL·beat-1, p<0.0001). Conclusion: Exercise tolerance was significantly lower in patients with COPD-PH than in patients with COPD-nonPH, particularly in nontransplant candidates.2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/183674Articles publicats en revistes (Medicina)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1183/16000617.0321-2020European Respiratory Review, 2021, vol. 30, num. 160, p. 200321https://doi.org/10.1183/16000617.0321-2020cc-by (c) Torres Castro, Rodrigo et al., 2021https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1836742026-05-27T06:46:51Z
dc.title.none.fl_str_mv Effect of pulmonary hypertension on exercise tolerance in patients with COPD: a prognostic systematic review and meta-analysis
title Effect of pulmonary hypertension on exercise tolerance in patients with COPD: a prognostic systematic review and meta-analysis
spellingShingle Effect of pulmonary hypertension on exercise tolerance in patients with COPD: a prognostic systematic review and meta-analysis
Torres Castro, Rodrigo
Malalties pulmonars obstructives cròniques
Hipertensió pulmonar
Chronic obstructive pulmonary diseases
Pulmonary hypertension
title_short Effect of pulmonary hypertension on exercise tolerance in patients with COPD: a prognostic systematic review and meta-analysis
title_full Effect of pulmonary hypertension on exercise tolerance in patients with COPD: a prognostic systematic review and meta-analysis
title_fullStr Effect of pulmonary hypertension on exercise tolerance in patients with COPD: a prognostic systematic review and meta-analysis
title_full_unstemmed Effect of pulmonary hypertension on exercise tolerance in patients with COPD: a prognostic systematic review and meta-analysis
title_sort Effect of pulmonary hypertension on exercise tolerance in patients with COPD: a prognostic systematic review and meta-analysis
dc.creator.none.fl_str_mv Torres Castro, Rodrigo
Gimeno Santos, Elena, 1980-
Vilaró, Jordi
Roqué Figuls, Marta
Moisés, Jorge
Vasconcello Castillo, Luis
Orizaga, Tanya
Barberà i Mir, Joan Albert
Blanco Vich, Isabel
author Torres Castro, Rodrigo
author_facet Torres Castro, Rodrigo
Gimeno Santos, Elena, 1980-
Vilaró, Jordi
Roqué Figuls, Marta
Moisés, Jorge
Vasconcello Castillo, Luis
Orizaga, Tanya
Barberà i Mir, Joan Albert
Blanco Vich, Isabel
author_role author
author2 Gimeno Santos, Elena, 1980-
Vilaró, Jordi
Roqué Figuls, Marta
Moisés, Jorge
Vasconcello Castillo, Luis
Orizaga, Tanya
Barberà i Mir, Joan Albert
Blanco Vich, Isabel
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Malalties pulmonars obstructives cròniques
Hipertensió pulmonar
Chronic obstructive pulmonary diseases
Pulmonary hypertension
topic Malalties pulmonars obstructives cròniques
Hipertensió pulmonar
Chronic obstructive pulmonary diseases
Pulmonary hypertension
description Background: Pulmonary hypertension (PH) is a frequent complication in patients with COPD. Objective: To determine if, in patients with COPD, the presence of PH decreases exercise tolerance. Methods: We included studies that analysed exercise tolerance using a cardiopulmonary exercise test (CPET) in patients with COPD with PH (COPD-PH) and without PH (COPD-nonPH). Two independent reviewers analysed the studies, extracted the data and assessed the quality of the evidence. Results: Of the 4915 articles initially identified, seven reported 257 patients with COPD-PH and 404 patients with COPD-nonPH. The COPD-PH group showed differences in peak oxygen consumption (V'O2peak ), -3.09 mL·kg-1·min-1 (95% CI -4.74 to -1.43, p=0.0003); maximum workload (Wmax), -20.5 W (95% CI -34.4 to -6.5, p=0.004); and oxygen pulse (O2 pulse), -1.24 mL·beat-1 (95% CI -2.40 to -0.09, p=0.03), in comparison to the group with COPD-nonPH. If we excluded studies with lung transplant candidates, the sensitivity analyses showed even bigger differences: V'O2 , -4.26 mL·min-1·kg-1 (95% CI -5.50 to -3.02 mL·kg-1·min-1, p<0.00001); Wmax, -26.6 W (95% CI -32.1 to -21.1 W, p<0.00001); and O2 pulse, -2.04 mL·beat-1 (95% CI -2.92 to -1.15 mL·beat-1, p<0.0001). Conclusion: Exercise tolerance was significantly lower in patients with COPD-PH than in patients with COPD-nonPH, particularly in nontransplant candidates.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/183674
url https://hdl.handle.net/2445/183674
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1183/16000617.0321-2020
European Respiratory Review, 2021, vol. 30, num. 160, p. 200321
https://doi.org/10.1183/16000617.0321-2020
dc.rights.none.fl_str_mv cc-by (c) Torres Castro, Rodrigo et al., 2021
https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Torres Castro, Rodrigo et al., 2021
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.300719

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