Effectiveness of ovarian age as the background risk for aneuploidy screening in an unselected pregnant population

The aim of this study was to assess the performance of first-trimester combined screening when replacing the chronological maternal age by Anti-Mullerian hormo(AMH) and antral follicle count (AFC)-derived ovarian ages, as the background risk in trisomy risk estimation. A total of 639 pregnant women...

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Autores: Grande M, Sabrià J, Borobio V, Mercadé I, Stergiotou I, Masoller N, Borrell A
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2016
País:España
Institución:Fundació Sant Joan de Déu
Repositorio:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
OAI Identifier:oai:fsjd.fundanetsuite.com:p9996
Acceso en línea:https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=9996
Access Level:acceso abierto
Palabra clave:anti-Mullerian hormone (AMH)
antral follicle count (AFC)
first trimester combined screening
trisomy 21
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spelling Effectiveness of ovarian age as the background risk for aneuploidy screening in an unselected pregnant populationGrande MSabrià JBorobio VMercadé IStergiotou IMasoller NBorrell Aanti-Mullerian hormone (AMH)antral follicle count (AFC)first trimester combined screeningtrisomy 21The aim of this study was to assess the performance of first-trimester combined screening when replacing the chronological maternal age by Anti-Mullerian hormo(AMH) and antral follicle count (AFC)-derived ovarian ages, as the background risk in trisomy risk estimation. A total of 639 pregnant women who completed first-trimester combined screening together with AMH and AFC determination were included. Trisomy risks were estimated based on three distinct 'maternal ages' as a-priori risk (chronological age, AMH-and AFC-derived ovarian age). The screening performance was assessed using three different approaches: received operator curve; detection rate and false positive rates for a fixed 1/250 threshold; and detection rates for a fixed 3% false positive rate. A non-significant trend was shown for AMH-derived age for both an increased area under the curve (0.986 versus 0.979) and an increased detection rate (from 83% to 100%) for a 1/250 risk threshold. For a 3% false-positive rate, a non-significant trend for increased detection with the use of both AMH- and AFC-derived ovarian ages was observed (from 67% to 83%). These results indicate that, although ovarian derived ages seem to potentially reflect a more precise background risk for fetal trisomies, the improvement in screening performance is only residual. (C) 2016 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.ELSEVIER SCI LTD2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=9996REPRODUCTIVE BIOMEDICINE ONLINEISSN: 14726483ISSNe: 14726491reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déuinstname:Fundació Sant Joan de DéuInglésinfo:eu-repo/semantics/openAccessoai:fsjd.fundanetsuite.com:p99962026-05-27T12:37:41Z
dc.title.none.fl_str_mv Effectiveness of ovarian age as the background risk for aneuploidy screening in an unselected pregnant population
title Effectiveness of ovarian age as the background risk for aneuploidy screening in an unselected pregnant population
spellingShingle Effectiveness of ovarian age as the background risk for aneuploidy screening in an unselected pregnant population
Grande M
anti-Mullerian hormone (AMH)
antral follicle count (AFC)
first trimester combined screening
trisomy 21
title_short Effectiveness of ovarian age as the background risk for aneuploidy screening in an unselected pregnant population
title_full Effectiveness of ovarian age as the background risk for aneuploidy screening in an unselected pregnant population
title_fullStr Effectiveness of ovarian age as the background risk for aneuploidy screening in an unselected pregnant population
title_full_unstemmed Effectiveness of ovarian age as the background risk for aneuploidy screening in an unselected pregnant population
title_sort Effectiveness of ovarian age as the background risk for aneuploidy screening in an unselected pregnant population
dc.creator.none.fl_str_mv Grande M
Sabrià J
Borobio V
Mercadé I
Stergiotou I
Masoller N
Borrell A
author Grande M
author_facet Grande M
Sabrià J
Borobio V
Mercadé I
Stergiotou I
Masoller N
Borrell A
author_role author
author2 Sabrià J
Borobio V
Mercadé I
Stergiotou I
Masoller N
Borrell A
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv anti-Mullerian hormone (AMH)
antral follicle count (AFC)
first trimester combined screening
trisomy 21
topic anti-Mullerian hormone (AMH)
antral follicle count (AFC)
first trimester combined screening
trisomy 21
description The aim of this study was to assess the performance of first-trimester combined screening when replacing the chronological maternal age by Anti-Mullerian hormo(AMH) and antral follicle count (AFC)-derived ovarian ages, as the background risk in trisomy risk estimation. A total of 639 pregnant women who completed first-trimester combined screening together with AMH and AFC determination were included. Trisomy risks were estimated based on three distinct 'maternal ages' as a-priori risk (chronological age, AMH-and AFC-derived ovarian age). The screening performance was assessed using three different approaches: received operator curve; detection rate and false positive rates for a fixed 1/250 threshold; and detection rates for a fixed 3% false positive rate. A non-significant trend was shown for AMH-derived age for both an increased area under the curve (0.986 versus 0.979) and an increased detection rate (from 83% to 100%) for a 1/250 risk threshold. For a 3% false-positive rate, a non-significant trend for increased detection with the use of both AMH- and AFC-derived ovarian ages was observed (from 67% to 83%). These results indicate that, although ovarian derived ages seem to potentially reflect a more precise background risk for fetal trisomies, the improvement in screening performance is only residual. (C) 2016 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.
publishDate 2016
dc.date.none.fl_str_mv 2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=9996
url https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=9996
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv ELSEVIER SCI LTD
publisher.none.fl_str_mv ELSEVIER SCI LTD
dc.source.none.fl_str_mv REPRODUCTIVE BIOMEDICINE ONLINE
ISSN: 14726483
ISSNe: 14726491
reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname:Fundació Sant Joan de Déu
instname_str Fundació Sant Joan de Déu
reponame_str r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
collection r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
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