Telomere length and 4-year changes in cognitive function in an older Mediterranean population at high risk of cardiovascular disease

Background: Cognitive decline, a common process of brain ageing, has been associated with telomere length (TL). Delving into the identification of reliable biomarkers of brain ageing is essential to prevent accelerated cognitive impairment. Methods: We selected 317 non-smoking 'Prevención con D...

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Autores: Fernández-de-la-Puente, M. (María)|||/items/71fe95a5-6986-4147-b39c-019fa90c0aff, Marti-del-Moral, A. (Amelia)|||/items/c62ba83d-ba7d-43aa-944c-3b57a06af670, Canudas, Silvia (S.)|||/items/c9a43494-f4e8-4375-8e57-2a69f15ac342, Zalba-Goñi, G. (Guillermo)|||/items/71410fa2-baa5-4efc-bce7-14b4b0e23802, Razquin-Burillo, C. (Cristina)|||/items/2b900a44-aca0-4449-9167-2756e88fae06, Boccardi, V. (Virginia)|||/items/4c56d9fe-7f77-498a-b816-3feccd010731, Mecocci, P. (P.)|||/items/d3e7d574-8f06-434b-8af3-74746d5e2de6, Babio, N. (Nancy)|||/items/5b6a2a17-b695-4712-9e4d-e9f3371dcc3c, Castañer, O. (Olga)|||/items/177ed76c-c237-4ac1-99b7-445c1b2e49dc, Toledo-Atucha, E. (Estefanía)|||/items/a67de95c-b88e-4c23-8fb9-6482b0f9fba0, Buil, P. (Pilar)|||/items/ac22e144-2996-4b2a-8537-e2912c8101c0, Salas-Salvado, J. (Jordi)|||/items/e2fc08dd-d21f-475b-83fa-157f0b0067e6, García-Calzón, S. (Sonia)|||/items/23d09531-c999-414f-a9f0-f5bfeb32e689
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universidad de Navarra
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglés
OAI Identifier:oai:dadun.unav.edu:10171/118834
Acceso en línea:https://hdl.handle.net/10171/118834
Access Level:acceso abierto
Palabra clave:Telomere length
Ageing
Biomarker
Cognitive function
Older people
Descripción
Sumario:Background: Cognitive decline, a common process of brain ageing, has been associated with telomere length (TL). Delving into the identification of reliable biomarkers of brain ageing is essential to prevent accelerated cognitive impairment. Methods: We selected 317 non-smoking 'Prevención con Dieta Mediterránea-Plus' (PREDIMED-Plus) participants (mean age, 65.8 ± 5.0 years) with metabolic syndrome from two trial centres who were following a lifestyle intervention. We measured TL and cognitive function at baseline and after 3 and 4 years of follow-up, respectively. Associations between baseline or 3-year changes in TL and baseline or 4-year changes in cognitive function were analysed using multivariable regression models. Results: Baseline TL was not associated with baseline cognitive performance. Nevertheless, longer baseline TL was associated with improved 4-year changes in the Executive Function domain (β: 0.29; 95%CI: 0.12 to 0.44; P < 0.001) and the Global Cognitive Function domain (β: 0.19; 95%CI: 0.05 to 0.34; P = 0.010). Besides, a positive association was found between longer baseline TL and improved 4-year changes in the animal version of the Verbal Fluency Test (β: 0.33; 95%CI: 0.12 to 0.52; P = 0.002). By contrast, 3-year changes in TL were not associated with changes in cognitive function after 4 years. Conclusions: Longer baseline TL could protect from cognitive decline and be used as a useful biomarker of brain ageing function in an older Mediterranean population at risk of cardiovascular disease and cognitive impairment.

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