Multidisciplinary treatment of soft tissue sarcomas: An update

Standard treatment for soft tissue sarcoma, based on complete surgical resection with or without adjuvant radiotherapy and chemotherapy, has not substantially changed during the last several decades. Nevertheless, recent advances have contributed to considerable improvement in the management of thes...

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Autores: Gómez-Gómez, J. (Jorge)|||/items/caf9de7c-12cd-4d5d-a823-811346cfca3f, Tsagozis, P. (Panagiotis)|||/items/2c48111f-e38c-464e-a67d-06e620aaf494
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universidad de Navarra
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglés
OAI Identifier:oai:dadun.unav.edu:10171/66050
Acceso en línea:https://hdl.handle.net/10171/66050
Access Level:acceso abierto
Palabra clave:Soft tissue sarcomas
Multidisciplinary treatment
Surgery
Radiotherapy
Chemotherapy
Targeted therapy
Update treatment
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spelling Multidisciplinary treatment of soft tissue sarcomas: An updateGómez-Gómez, J. (Jorge)|||/items/caf9de7c-12cd-4d5d-a823-811346cfca3fTsagozis, P. (Panagiotis)|||/items/2c48111f-e38c-464e-a67d-06e620aaf494Soft tissue sarcomasMultidisciplinary treatmentSurgeryRadiotherapyChemotherapyTargeted therapyUpdate treatmentStandard treatment for soft tissue sarcoma, based on complete surgical resection with or without adjuvant radiotherapy and chemotherapy, has not substantially changed during the last several decades. Nevertheless, recent advances have contributed to considerable improvement in the management of these patients; for example, new magnetic resonance imaging sequences such as diffusionweighted imaging and magnetic resonance imaging radiomics can better assess tumor extension and even estimate its grade. Detection of circulating genetic material (liquid biopsy) and next-generation sequencing are powerful techniques for genetic analysis, which will increase our understanding of the underlying molecular mechanisms and may reveal potential therapeutic targets. The role of chemotherapy in non-metastatic disease is still controversial, and there is a need to identify patients who really benefit from this treatment. Novel chemotherapeutic regimens have entered clinical praxis and can change the outcome of patients with metastatic disease. Advances in radiotherapy have helped decrease local adverse effects and sustain good local control of the disease. The following report provides an updated view of the diagnosis, treatment, and future perspectives on the management of patients with soft tissue sarcomas.BPGDadun. Depósito Académico Digital Universidad de Navarra20232023-04-2020202020-01-0120202020-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/66050reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/660502026-06-21T12:47:57Z
dc.title.none.fl_str_mv Multidisciplinary treatment of soft tissue sarcomas: An update
title Multidisciplinary treatment of soft tissue sarcomas: An update
spellingShingle Multidisciplinary treatment of soft tissue sarcomas: An update
Gómez-Gómez, J. (Jorge)|||/items/caf9de7c-12cd-4d5d-a823-811346cfca3f
Soft tissue sarcomas
Multidisciplinary treatment
Surgery
Radiotherapy
Chemotherapy
Targeted therapy
Update treatment
title_short Multidisciplinary treatment of soft tissue sarcomas: An update
title_full Multidisciplinary treatment of soft tissue sarcomas: An update
title_fullStr Multidisciplinary treatment of soft tissue sarcomas: An update
title_full_unstemmed Multidisciplinary treatment of soft tissue sarcomas: An update
title_sort Multidisciplinary treatment of soft tissue sarcomas: An update
dc.creator.none.fl_str_mv Gómez-Gómez, J. (Jorge)|||/items/caf9de7c-12cd-4d5d-a823-811346cfca3f
Tsagozis, P. (Panagiotis)|||/items/2c48111f-e38c-464e-a67d-06e620aaf494
author Gómez-Gómez, J. (Jorge)|||/items/caf9de7c-12cd-4d5d-a823-811346cfca3f
author_facet Gómez-Gómez, J. (Jorge)|||/items/caf9de7c-12cd-4d5d-a823-811346cfca3f
Tsagozis, P. (Panagiotis)|||/items/2c48111f-e38c-464e-a67d-06e620aaf494
author_role author
author2 Tsagozis, P. (Panagiotis)|||/items/2c48111f-e38c-464e-a67d-06e620aaf494
author2_role author
dc.contributor.none.fl_str_mv Dadun. Depósito Académico Digital Universidad de Navarra
dc.subject.none.fl_str_mv Soft tissue sarcomas
Multidisciplinary treatment
Surgery
Radiotherapy
Chemotherapy
Targeted therapy
Update treatment
topic Soft tissue sarcomas
Multidisciplinary treatment
Surgery
Radiotherapy
Chemotherapy
Targeted therapy
Update treatment
description Standard treatment for soft tissue sarcoma, based on complete surgical resection with or without adjuvant radiotherapy and chemotherapy, has not substantially changed during the last several decades. Nevertheless, recent advances have contributed to considerable improvement in the management of these patients; for example, new magnetic resonance imaging sequences such as diffusionweighted imaging and magnetic resonance imaging radiomics can better assess tumor extension and even estimate its grade. Detection of circulating genetic material (liquid biopsy) and next-generation sequencing are powerful techniques for genetic analysis, which will increase our understanding of the underlying molecular mechanisms and may reveal potential therapeutic targets. The role of chemotherapy in non-metastatic disease is still controversial, and there is a need to identify patients who really benefit from this treatment. Novel chemotherapeutic regimens have entered clinical praxis and can change the outcome of patients with metastatic disease. Advances in radiotherapy have helped decrease local adverse effects and sustain good local control of the disease. The following report provides an updated view of the diagnosis, treatment, and future perspectives on the management of patients with soft tissue sarcomas.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-01-01
2020
2020-01-01
2023
2023-04-20
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10171/66050
url https://hdl.handle.net/10171/66050
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
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eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BPG
publisher.none.fl_str_mv BPG
dc.source.none.fl_str_mv reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra
instname:Universidad de Navarra
instname_str Universidad de Navarra
reponame_str Dadun. Depósito Académico Digital de la Universidad de Navarra
collection Dadun. Depósito Académico Digital de la Universidad de Navarra
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