Type 2 diabetes is associated with decreased PGC1α expression in epicardial adipose tissue of patients with coronary artery disease.
Although recent studies indicate that epicardial adipose tissue expresses brown fat-like genes, such as PGC1α, UCP1 and PRDM16, the association of these genes with type 2 diabetes mellitus (DM2) in coronary artery disease (CAD) remains unknown. PGC1α, UCP1, and PRDM16 mRNAs expression levels were me...
| Autores: | , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2016 |
| País: | España |
| Institución: | Instituto de Salud Carlos III (ISCIII) |
| Repositorio: | Repisalud |
| Idioma: | inglés |
| OAI Identifier: | oai:repisalud.isciii.es:20.500.12105/17149 |
| Acceso en línea: | http://hdl.handle.net/20.500.12105/17149 |
| Access Level: | acceso abierto |
| Palabra clave: | Coronary artery disease Epicardial adipose tissue Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α) Type 2 diabetes mellitus Adipose Tissue Coronary Artery Disease DNA-Binding Proteins Diabetes Mellitus, Type 2 Female Gene Expression Regulation Humans Logistic Models Male Middle Aged Pericardium Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha RNA, Messenger Subcutaneous Fat Thermogenesis Transcription Factors Uncoupling Protein 1 |
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Type 2 diabetes is associated with decreased PGC1α expression in epicardial adipose tissue of patients with coronary artery disease.Moreno-Santos, InmaculadaPérez-Belmonte, Luis MiguelMacías-González, ManuelMataró, María JoséCastellano, DanielLópez-Garrido, MiguelPorras-Martín, CarlosSánchez-Fernández, Pedro LGómez-Doblas, Juan JoséCardona, Fernandode Teresa-Galván, EduardoJiménez-Navarro, ManuelCoronary artery diseaseEpicardial adipose tissuePeroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α)Type 2 diabetes mellitusAdipose TissueCoronary Artery DiseaseDNA-Binding ProteinsDiabetes Mellitus, Type 2FemaleGene Expression RegulationHumansLogistic ModelsMaleMiddle AgedPericardiumPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaRNA, MessengerSubcutaneous FatThermogenesisTranscription FactorsUncoupling Protein 1Although recent studies indicate that epicardial adipose tissue expresses brown fat-like genes, such as PGC1α, UCP1 and PRDM16, the association of these genes with type 2 diabetes mellitus (DM2) in coronary artery disease (CAD) remains unknown. PGC1α, UCP1, and PRDM16 mRNAs expression levels were measured by real-time PCR in epicardial and thoracic subcutaneous adipose tissue from 44 CAD patients (22 with DM2 [CAD-DM2] and 22 without DM2 [CAD-NDM2]) and 23 non-CAD patients (NCAD). The CAD-DM2 patients had significantly lower PGC1α and UCP1 expression in epicardial adipose tissue than the CAD-NDM2 and NCAD patients. However, PGC1α and UCP1 mRNA trended upward in subcutaneous adipose tissue from CAD-DM2 patients. At multiple regression analysis, age, body mass index, left ventricular ejection fraction, UCP1 expression of epicardial adipose tissue and diabetes came out to be independent predictors of PGC1α levels. Epicardial adipose tissue PGC1α expression was dependent on the number of injured coronary arteries and logistic regression analysis showed that PGC1α expression in epicardial adipose tissue could exert a protective effect against coronary lesions. DM2 is associated with decreased expression of PGC1α and UCP1 mRNA in epicardial adipose tissue of patients with CAD, likely reflecting a loss of brown-like fat features. Decreased expression of PGC1α in human epicardial adipose tissue is associated with higher prevalence of coronary lesions.20242024-01-1620162016-08-1920162016-08-19research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articlehttp://hdl.handle.net/20.500.12105/17149reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/171492026-06-12T12:43:37Z |
| dc.title.none.fl_str_mv |
Type 2 diabetes is associated with decreased PGC1α expression in epicardial adipose tissue of patients with coronary artery disease. |
| title |
Type 2 diabetes is associated with decreased PGC1α expression in epicardial adipose tissue of patients with coronary artery disease. |
| spellingShingle |
Type 2 diabetes is associated with decreased PGC1α expression in epicardial adipose tissue of patients with coronary artery disease. Moreno-Santos, Inmaculada Coronary artery disease Epicardial adipose tissue Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α) Type 2 diabetes mellitus Adipose Tissue Coronary Artery Disease DNA-Binding Proteins Diabetes Mellitus, Type 2 Female Gene Expression Regulation Humans Logistic Models Male Middle Aged Pericardium Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha RNA, Messenger Subcutaneous Fat Thermogenesis Transcription Factors Uncoupling Protein 1 |
| title_short |
Type 2 diabetes is associated with decreased PGC1α expression in epicardial adipose tissue of patients with coronary artery disease. |
| title_full |
Type 2 diabetes is associated with decreased PGC1α expression in epicardial adipose tissue of patients with coronary artery disease. |
| title_fullStr |
Type 2 diabetes is associated with decreased PGC1α expression in epicardial adipose tissue of patients with coronary artery disease. |
| title_full_unstemmed |
Type 2 diabetes is associated with decreased PGC1α expression in epicardial adipose tissue of patients with coronary artery disease. |
| title_sort |
Type 2 diabetes is associated with decreased PGC1α expression in epicardial adipose tissue of patients with coronary artery disease. |
| dc.creator.none.fl_str_mv |
Moreno-Santos, Inmaculada Pérez-Belmonte, Luis Miguel Macías-González, Manuel Mataró, María José Castellano, Daniel López-Garrido, Miguel Porras-Martín, Carlos Sánchez-Fernández, Pedro L Gómez-Doblas, Juan José Cardona, Fernando de Teresa-Galván, Eduardo Jiménez-Navarro, Manuel |
| author |
Moreno-Santos, Inmaculada |
| author_facet |
Moreno-Santos, Inmaculada Pérez-Belmonte, Luis Miguel Macías-González, Manuel Mataró, María José Castellano, Daniel López-Garrido, Miguel Porras-Martín, Carlos Sánchez-Fernández, Pedro L Gómez-Doblas, Juan José Cardona, Fernando de Teresa-Galván, Eduardo Jiménez-Navarro, Manuel |
| author_role |
author |
| author2 |
Pérez-Belmonte, Luis Miguel Macías-González, Manuel Mataró, María José Castellano, Daniel López-Garrido, Miguel Porras-Martín, Carlos Sánchez-Fernández, Pedro L Gómez-Doblas, Juan José Cardona, Fernando de Teresa-Galván, Eduardo Jiménez-Navarro, Manuel |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
|
| dc.subject.none.fl_str_mv |
Coronary artery disease Epicardial adipose tissue Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α) Type 2 diabetes mellitus Adipose Tissue Coronary Artery Disease DNA-Binding Proteins Diabetes Mellitus, Type 2 Female Gene Expression Regulation Humans Logistic Models Male Middle Aged Pericardium Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha RNA, Messenger Subcutaneous Fat Thermogenesis Transcription Factors Uncoupling Protein 1 |
| topic |
Coronary artery disease Epicardial adipose tissue Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α) Type 2 diabetes mellitus Adipose Tissue Coronary Artery Disease DNA-Binding Proteins Diabetes Mellitus, Type 2 Female Gene Expression Regulation Humans Logistic Models Male Middle Aged Pericardium Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha RNA, Messenger Subcutaneous Fat Thermogenesis Transcription Factors Uncoupling Protein 1 |
| description |
Although recent studies indicate that epicardial adipose tissue expresses brown fat-like genes, such as PGC1α, UCP1 and PRDM16, the association of these genes with type 2 diabetes mellitus (DM2) in coronary artery disease (CAD) remains unknown. PGC1α, UCP1, and PRDM16 mRNAs expression levels were measured by real-time PCR in epicardial and thoracic subcutaneous adipose tissue from 44 CAD patients (22 with DM2 [CAD-DM2] and 22 without DM2 [CAD-NDM2]) and 23 non-CAD patients (NCAD). The CAD-DM2 patients had significantly lower PGC1α and UCP1 expression in epicardial adipose tissue than the CAD-NDM2 and NCAD patients. However, PGC1α and UCP1 mRNA trended upward in subcutaneous adipose tissue from CAD-DM2 patients. At multiple regression analysis, age, body mass index, left ventricular ejection fraction, UCP1 expression of epicardial adipose tissue and diabetes came out to be independent predictors of PGC1α levels. Epicardial adipose tissue PGC1α expression was dependent on the number of injured coronary arteries and logistic regression analysis showed that PGC1α expression in epicardial adipose tissue could exert a protective effect against coronary lesions. DM2 is associated with decreased expression of PGC1α and UCP1 mRNA in epicardial adipose tissue of patients with CAD, likely reflecting a loss of brown-like fat features. Decreased expression of PGC1α in human epicardial adipose tissue is associated with higher prevalence of coronary lesions. |
| publishDate |
2016 |
| dc.date.none.fl_str_mv |
2016 2016-08-19 2016 2016-08-19 2024 2024-01-16 |
| dc.type.none.fl_str_mv |
research article http://purl.org/coar/resource_type/c_2df8fbb1 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/20.500.12105/17149 |
| url |
http://hdl.handle.net/20.500.12105/17149 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ |
| dc.rights.openaire.fl_str_mv |
info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
open access http://purl.org/coar/access_right/c_abf2 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ |
| eu_rights_str_mv |
openAccess |
| dc.source.none.fl_str_mv |
reponame:Repisalud instname:Instituto de Salud Carlos III (ISCIII) |
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Instituto de Salud Carlos III (ISCIII) |
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Repisalud |
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Repisalud |
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1869421117069852672 |
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15,81155 |