Personalized monitoring of electrical remodelling during atrial fibrillation progression via remote transmissions from implantable devices

Aims Atrial electrical remodelling (AER) is a transitional period associated with the progression and long-term maintenance of atrial fibrillation (AF). We aimed to study the progression of AER in individual patients with implantable devices and AF episodes. Methods and results Observational multice...

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Autores: Lillo-Castellano, Jose Maria, Gonzalez-Ferrer, Juan Jose, Marina-Breysse, Manuel, Martinez-Ferrer, Jose Bautista, Perez-Alvarez, Luisa, Alzueta, Javier, MARTINEZ, J., Rodriguez, Anibal, Rodriguez-Perez, Juan Carlos, Anguera, Ignasi, Vinolas, Xavier, Garcia-Alberola, Arcadio, Quintanilla, Jorge G, Alfonso-Almazan, Jose Manuel, Garcia, Javier, Borrego, Luis, Canadas-Godoy, Victoria, Perez-Castellano, Nicasio, Perez-Villacastin, Julian, Jimenez-Diaz, Javier, Jalife, Jose, Filgueiras-Rama, David
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Repositorio:r-FISABIO. Repositorio Institucional de Producción Científica
OAI Identifier:oai:fisabio.fundanetsuite.com:p5147
Acceso en línea:https://fisabio.portalinvestigacion.com/publicaciones/5147
Access Level:acceso abierto
Palabra clave:Atrial fibrillation
Atrial fibrillation progression
Electrical remodeling
Implantable cardioverter-defibrillator
eHealth
Telemedicine
Mobile health
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spelling Personalized monitoring of electrical remodelling during atrial fibrillation progression via remote transmissions from implantable devicesLillo-Castellano, Jose MariaGonzalez-Ferrer, Juan JoseMarina-Breysse, ManuelMartinez-Ferrer, Jose BautistaPerez-Alvarez, LuisaAlzueta, JavierMARTINEZ, J.Rodriguez, AnibalRodriguez-Perez, Juan CarlosAnguera, IgnasiVinolas, XavierGarcia-Alberola, ArcadioQuintanilla, Jorge GAlfonso-Almazan, Jose ManuelGarcia, JavierBorrego, LuisCanadas-Godoy, VictoriaPerez-Castellano, NicasioPerez-Villacastin, JulianJimenez-Diaz, JavierJalife, JoseFilgueiras-Rama, DavidAtrial fibrillationAtrial fibrillation progressionElectrical remodelingImplantable cardioverter-defibrillatoreHealthTelemedicineMobile healthAims Atrial electrical remodelling (AER) is a transitional period associated with the progression and long-term maintenance of atrial fibrillation (AF). We aimed to study the progression of AER in individual patients with implantable devices and AF episodes. Methods and results Observational multicentre study (51 centres) including 4618 patients with implantable cardioverter-defibrillator +/-resynchronization therapy (ICD/CRT-D) and 352 patients (2 centres) with pacemakers (median follow-up: 3.4 years). Atrial activation rate (AAR) was quantified as the frequency of the dominant peak in the signal spectrum of AF episodes with atrial bipolar etectrograms. Patients with complete progression of AER, from paroxysmal AF episodes to electrically remodelled persistent AF, were used to depict patient-specific AER slopes. A total of 34 712 AF tracings from 830 patients (87 with pacemakers) were suitable for the study. Complete progression of AER was documented in 216 patients (16 with pacemakers). Patients with persistent AF after completion of AER showed , similar to 30% faster AAR than patients with paroxysmal AF. The slope of AAR changes during AF progression revealed patient-specific patterns that correlated with the time-to-completion of AER (R-2 = 0.85). Pacemaker patients were older than patients with ICD/CRT-Ds (78.3 vs. 67.2 year olds, respectively, P< 0.001) and had a shorter median time-to-completion of AER (24.9 vs. 93.5 days, respectively, P = 0.016). Remote transmissions in patients with ICD/CRT-D devices enabled the estimation of the time-to-completion of AER using the predicted slope of AAR changes from initiation to completion of electrical remodelling (R-2 = 0.45). Conclusions The AF progression shows patient-specific patterns of AER, which can be estimated using available remote-monitoring technology.OXFORD UNIV PRESS2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fisabio.portalinvestigacion.com/publicaciones/5147EUROPACEISSN: 10995129ISSNe: 15322092reponame:r-FISABIO. Repositorio Institucional de Producción Científicainstname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)Inglésinfo:eu-repo/semantics/openAccessoai:fisabio.fundanetsuite.com:p51472026-06-11T12:45:17Z
dc.title.none.fl_str_mv Personalized monitoring of electrical remodelling during atrial fibrillation progression via remote transmissions from implantable devices
title Personalized monitoring of electrical remodelling during atrial fibrillation progression via remote transmissions from implantable devices
spellingShingle Personalized monitoring of electrical remodelling during atrial fibrillation progression via remote transmissions from implantable devices
Lillo-Castellano, Jose Maria
Atrial fibrillation
Atrial fibrillation progression
Electrical remodeling
Implantable cardioverter-defibrillator
eHealth
Telemedicine
Mobile health
title_short Personalized monitoring of electrical remodelling during atrial fibrillation progression via remote transmissions from implantable devices
title_full Personalized monitoring of electrical remodelling during atrial fibrillation progression via remote transmissions from implantable devices
title_fullStr Personalized monitoring of electrical remodelling during atrial fibrillation progression via remote transmissions from implantable devices
title_full_unstemmed Personalized monitoring of electrical remodelling during atrial fibrillation progression via remote transmissions from implantable devices
title_sort Personalized monitoring of electrical remodelling during atrial fibrillation progression via remote transmissions from implantable devices
dc.creator.none.fl_str_mv Lillo-Castellano, Jose Maria
Gonzalez-Ferrer, Juan Jose
Marina-Breysse, Manuel
Martinez-Ferrer, Jose Bautista
Perez-Alvarez, Luisa
Alzueta, Javier
MARTINEZ, J.
Rodriguez, Anibal
Rodriguez-Perez, Juan Carlos
Anguera, Ignasi
Vinolas, Xavier
Garcia-Alberola, Arcadio
Quintanilla, Jorge G
Alfonso-Almazan, Jose Manuel
Garcia, Javier
Borrego, Luis
Canadas-Godoy, Victoria
Perez-Castellano, Nicasio
Perez-Villacastin, Julian
Jimenez-Diaz, Javier
Jalife, Jose
Filgueiras-Rama, David
author Lillo-Castellano, Jose Maria
author_facet Lillo-Castellano, Jose Maria
Gonzalez-Ferrer, Juan Jose
Marina-Breysse, Manuel
Martinez-Ferrer, Jose Bautista
Perez-Alvarez, Luisa
Alzueta, Javier
MARTINEZ, J.
Rodriguez, Anibal
Rodriguez-Perez, Juan Carlos
Anguera, Ignasi
Vinolas, Xavier
Garcia-Alberola, Arcadio
Quintanilla, Jorge G
Alfonso-Almazan, Jose Manuel
Garcia, Javier
Borrego, Luis
Canadas-Godoy, Victoria
Perez-Castellano, Nicasio
Perez-Villacastin, Julian
Jimenez-Diaz, Javier
Jalife, Jose
Filgueiras-Rama, David
author_role author
author2 Gonzalez-Ferrer, Juan Jose
Marina-Breysse, Manuel
Martinez-Ferrer, Jose Bautista
Perez-Alvarez, Luisa
Alzueta, Javier
MARTINEZ, J.
Rodriguez, Anibal
Rodriguez-Perez, Juan Carlos
Anguera, Ignasi
Vinolas, Xavier
Garcia-Alberola, Arcadio
Quintanilla, Jorge G
Alfonso-Almazan, Jose Manuel
Garcia, Javier
Borrego, Luis
Canadas-Godoy, Victoria
Perez-Castellano, Nicasio
Perez-Villacastin, Julian
Jimenez-Diaz, Javier
Jalife, Jose
Filgueiras-Rama, David
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Atrial fibrillation
Atrial fibrillation progression
Electrical remodeling
Implantable cardioverter-defibrillator
eHealth
Telemedicine
Mobile health
topic Atrial fibrillation
Atrial fibrillation progression
Electrical remodeling
Implantable cardioverter-defibrillator
eHealth
Telemedicine
Mobile health
description Aims Atrial electrical remodelling (AER) is a transitional period associated with the progression and long-term maintenance of atrial fibrillation (AF). We aimed to study the progression of AER in individual patients with implantable devices and AF episodes. Methods and results Observational multicentre study (51 centres) including 4618 patients with implantable cardioverter-defibrillator +/-resynchronization therapy (ICD/CRT-D) and 352 patients (2 centres) with pacemakers (median follow-up: 3.4 years). Atrial activation rate (AAR) was quantified as the frequency of the dominant peak in the signal spectrum of AF episodes with atrial bipolar etectrograms. Patients with complete progression of AER, from paroxysmal AF episodes to electrically remodelled persistent AF, were used to depict patient-specific AER slopes. A total of 34 712 AF tracings from 830 patients (87 with pacemakers) were suitable for the study. Complete progression of AER was documented in 216 patients (16 with pacemakers). Patients with persistent AF after completion of AER showed , similar to 30% faster AAR than patients with paroxysmal AF. The slope of AAR changes during AF progression revealed patient-specific patterns that correlated with the time-to-completion of AER (R-2 = 0.85). Pacemaker patients were older than patients with ICD/CRT-Ds (78.3 vs. 67.2 year olds, respectively, P< 0.001) and had a shorter median time-to-completion of AER (24.9 vs. 93.5 days, respectively, P = 0.016). Remote transmissions in patients with ICD/CRT-D devices enabled the estimation of the time-to-completion of AER using the predicted slope of AAR changes from initiation to completion of electrical remodelling (R-2 = 0.45). Conclusions The AF progression shows patient-specific patterns of AER, which can be estimated using available remote-monitoring technology.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fisabio.portalinvestigacion.com/publicaciones/5147
url https://fisabio.portalinvestigacion.com/publicaciones/5147
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv OXFORD UNIV PRESS
publisher.none.fl_str_mv OXFORD UNIV PRESS
dc.source.none.fl_str_mv EUROPACE
ISSN: 10995129
ISSNe: 15322092
reponame:r-FISABIO. Repositorio Institucional de Producción Científica
instname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
instname_str Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
reponame_str r-FISABIO. Repositorio Institucional de Producción Científica
collection r-FISABIO. Repositorio Institucional de Producción Científica
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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